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THE GENESIS MACHINE

OUR QUEST TO REWRITE LIFE IN THE AGE OF SYNTHETIC BIOLOGY

A wrinkle on the near future that many readers will not have pondered—and should.

A look at the coming revolution in biotechnology, with all its possible goods and evils.

“A great transformation of life is underway,” write futurist Webb and geneticist Hessel. The rising field of synthetic biology, with its underlying technology of gene editing, will allow for numerous things that do not yet exist, including the ability to sequence the genome of a virus nearly immediately, affording scientists a vast library of viruses that will provide the wherewithal to “cure any genetic disease in humankind.” That revolution, the authors write, will remake food, energy, transportation, the supply chain, and commerce as a whole. Granted, write Webb and Hessel, this is a vast Pandora’s box. Synthetic biology is largely the province of corporations and governments in the developed world, and it is not outside the realm of reason to think that a corporation might maximize profit or a government, political gain through its ability to control the food supply and indeed the genetic library of the planet. The problem, as the authors note in deeply researched but accessible prose, is that there is little in the way of coherence in terms of international agreements or “consensus on the acceptable circumstances under which humans should manipulate human, animal, or plant life.” Part of that problem is the generally laissez faire attitude of some governments, especially the U.S., to develop regulations that “don’t intervene until there’s a problem, so as not to stifle innovations.” Because the current regulatory climate isn’t well structured for future-proofing, one important step is the development of a body of law and convention acknowledging that “this new approach to biology warrants a new approach to regulation,” balancing the public good with scientific and commercial interests. The authors propose planks of a platform to this end while noting the difficulty of reining in tech-driven countries such as China to honor international licensing systems and other controls.

A wrinkle on the near future that many readers will not have pondered—and should.

Pub Date: Feb. 15, 2022

ISBN: 978-1-5417-9791-8

Page Count: 368

Publisher: PublicAffairs

Review Posted Online: Nov. 26, 2021

Kirkus Reviews Issue: Dec. 15, 2021

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WHY FISH DON'T EXIST

A STORY OF LOSS, LOVE, AND THE HIDDEN ORDER OF LIFE

A quirky wonder of a book.

A Peabody Award–winning NPR science reporter chronicles the life of a turn-of-the-century scientist and how her quest led to significant revelations about the meaning of order, chaos, and her own existence.

Miller began doing research on David Starr Jordan (1851-1931) to understand how he had managed to carry on after the 1906 San Francisco earthquake destroyed his work. A taxonomist who is credited with discovering “a full fifth of fish known to man in his day,” Jordan had amassed an unparalleled collection of ichthyological specimens. Gathering up all the fish he could save, Jordan sewed the nameplates that had been on the destroyed jars directly onto the fish. His perseverance intrigued the author, who also discusses the struggles she underwent after her affair with a woman ended a heterosexual relationship. Born into an upstate New York farm family, Jordan attended Cornell and then became an itinerant scholar and field researcher until he landed at Indiana University, where his first ichthyological collection was destroyed by lightning. In between this catastrophe and others involving family members’ deaths, he reconstructed his collection. Later, he was appointed as the founding president of Stanford, where he evolved into a Machiavellian figure who trampled on colleagues and sang the praises of eugenics. Miller concludes that Jordan displayed the characteristics of someone who relied on “positive illusions” to rebound from disaster and that his stand on eugenics came from a belief in “a divine hierarchy from bacteria to humans that point[ed]…toward better.” Considering recent research that negates biological hierarchies, the author then suggests that Jordan’s beloved taxonomic category—fish—does not exist. Part biography, part science report, and part meditation on how the chaos that caused Miller’s existential misery could also bring self-acceptance and a loving wife, this unique book is an ingenious celebration of diversity and the mysterious order that underlies all existence.

A quirky wonder of a book.

Pub Date: April 14, 2020

ISBN: 978-1-5011-6027-1

Page Count: 224

Publisher: Simon & Schuster

Review Posted Online: Jan. 1, 2020

Kirkus Reviews Issue: Feb. 1, 2020

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THE LITTLE BOOK OF ALIENS

Solid data and reasoned conjecture strike a harmonious balance in a new SETI.

A jocular title does not even hint at the real wonders of this cook’s tour of alien life.

Astrophysicist Frank, author of Light of the Stars and The Constant Fire, has been obsessed with the idea of extraterrestrial life since childhood. After years of dreaming about exploring the cosmos for signs of intelligent life, he and other scientists are on the threshold of a new era of unprecedented discovery in the field of astrobiology. He details not only recent revelations in the detection of exoplanets, but also the search for technosignatures, indicators of technologically advanced species on worlds light years distant. These are not merely elements of science fiction. They are realities now within human reach thanks to the continuing development of ultra-powerful telescopes and to the sea change in a scientific culture that once scoffed at the Search for Extraterrestrial Intelligence (SETI). Frank’s enthusiasm is contagious, occasionally over-exuberant, and there is plenty of hard science in this survey, which the author presents with economy and accessibility. The book brims with fascinating facts and speculations, from the particulars of astrobiology to Dyson spheres. Frank’s cosmic tour makes stops at such milestones as the Fermi Paradox and the Drake Equation, showing how these 1950s advances continue to inform our thinking about the possibility of technological civilizations. The author also recounts the origins and current manifestations of the UFO craze and how the advancement of actual science has been impeded by 70 years of pop culture images that haunt our collective expectations. Frank advises we look for alien life where it most likely exists: deep space. He also stresses the key point that we have only begun to peer into the universe with instruments capable of breakthrough discoveries, a useful riposte to critics of the effort. Throughout, Frank champions the importance of demanding standards of evidence: “They are, literally, why science works.”

Solid data and reasoned conjecture strike a harmonious balance in a new SETI.

Pub Date: Nov. 21, 2023

ISBN: 9780063279735

Page Count: 256

Publisher: Harper/HarperCollins

Review Posted Online: Aug. 26, 2023

Kirkus Reviews Issue: Sept. 15, 2023

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