CRISPR EVOLUTION

Jones’ debut SF novel sees a rogue geneticist on the run from government agencies as his illegally engineered twins reach a crisis point in their evolutionary programming.

In the year 2050, the U.S. government centralized the funding of biomedical research and established a federal institute that focused on risk-free projects. Those working on the field’s cutting edge knuckled under, left the country, or went off-grid, operating illegally in makeshift laboratories. Gifted geneticist Howard Wake took the latter course, and by the year 2070, he has 8-year-old twins—Aurie and Py—incubated ex vivo using eggs stolen from colleague Jacqueline Witt. He’s implanted Py and Aurie with CRISPR, a virus engineered to quickly evolve the kids at a genomic level. Unbeknownst to Howard, the eggs’ special property—an embedded “kill switch,” designed to terminate pregnancies should embryos develop certain abnormalities—are in the twins’ DNA. Thus, the CRISPR evolutionary imperative is at odds with a safeguard that could kill Aurie and Py. A medical emergency pushes the Wake family into the open; on the run in New England, they seek refuge with Howard’s reclusive older brother, Abel. Jacqueline, meanwhile, discovers the theft of her eggs and tracks Howard down, determined to meet her biological children—one of whom is starting to become something beyond human. Over the course of this novel, Jones crafts a narrative that makes its concepts clear without belaboring the scientific aspects. Howard and Jacqueline are likable, deftly drawn characters, and Aurie and Py are similarly engaging—precocious, sometimes otherworldly, but still recognizably children. The society in which they live is a dark but believable extrapolation from present-day attitudes toward research funding, and the novel handles its moral questions sensitively and fairly throughout. It’s a testament to Jones’ skillful storytelling that readers may find themselves unsure how they want Aurie’s transformation to play out in the end.

A tale that provides readers with a penetrating and thought-provoking glimpse into a possible not-so-distant future.