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TINDERBOX

HOW THE WEST SPARKED THE AIDS EPIDEMIC AND HOW THE WORLD CAN FINALLY OVERCOME IT

Timberg and Halperin may ruffle feathers with some of their unorthodox views, but they present a forceful case with which...

Timberg, the former Johannesburg bureau chief for the Washington Post and current deputy national security editor, and Halperin, an epidemiologist and AIDS expert at Harvard, trace the history, growth and spread of HIV and present what will in the minds of many be a controversial approach to addressing the disease.

Although the subtitle sounds vaguely conspiratorial, the authors crisply chronicle the origins of AIDS from chimpanzees in West Africa and follow the perhaps shockingly slow spread of HIV across the African continent and to the rest of the world. The key factor in the spread of the disease was the expansion of European colonialism in Africa, which took a virus that otherwise may well have died off and instead created the conditions by which, decades later, it would become a scourge in many parts of the world. But European colonial-era malfeasance is not the only issue at work in this book. In addition to a useful history of the disease, Timberg and Halperin examine how to confront it and develop more effective ways to fight it. If Western imperialism is to blame for the initial proliferation of HIV/AIDS, Western arrogance and the unintended consequences of good intentions may well have prevented adequate treatment. While Western health advocates have supported abstinence campaigns and condom use, the authors argue that homegrown initiatives hold more promise than many Westerners have been willing to acknowledge, and that new research on the importance of sexual behavior and male circumcision is central to developing a coherent approach going forward.

Timberg and Halperin may ruffle feathers with some of their unorthodox views, but they present a forceful case with which future students of HIV and AIDS will have to reckon.

Pub Date: March 5, 2012

ISBN: 978-1-59420-327-5

Page Count: 430

Publisher: Penguin Press

Review Posted Online: Jan. 23, 2012

Kirkus Reviews Issue: Feb. 1, 2012

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A SHORT GUIDE TO A LONG LIFE

Useful but disappointingly commonplace tips.

In a follow-up to The End of Illness (2012), which explored how technological advances will transform medicine, Agus (Medicine and Engineering/Univ. of Southern California) restates time-tested but too often overlooked principles for healthy living.

The author outlines simple measures that average citizens can take to live healthier lives and extend their life spans by taking advantage of modern technology to develop personalized records. These would include a list of medical tests and recommended treatments. Agus also suggests keeping track of indicators that can be observed at home on a regular basis—e.g., changes in energy, weight, appetite and blood pressure, blood sugar and general appearance. He advises that all of this information be made available online, and it is also helpful to investigate family history and consider DNA testing where indicated. Along with maintaining a healthy weight, Agus emphasizes the importance of eating a balanced diet, with plenty of fresh fruits and vegetables and a minimum of red meat. Avoid packaged vitamins and food supplements, and if possible, grow your own vegetables or buy frozen vegetables, which will generally be fresher than those on supermarket shelves. The author also warns against processed foods that make health claims but contain additives or excessive amounts of sugar or fat. Regular mealtimes and plenty of sleep, frequent hand-washing and oral hygiene are a must; smoking and excessive time in the sun should also be avoided. Agus recommends that adults should consider taking statins and baby aspirin as preventative measures. He concludes with a decade-by-decade checklist of annual medical examinations that should be routine—e.g. blood pressure, diabetes and cholesterol screenings, from one’s 20s on; colonoscopies, prostate exams and mammograms later—and a variety of top-10 lists (for example, “Top 10 Reasons to Take a Walk”).

Useful but disappointingly commonplace tips.

Pub Date: Jan. 7, 2014

ISBN: 978-1-4767-3095-0

Page Count: 128

Publisher: Simon & Schuster

Review Posted Online: Sept. 30, 2013

Kirkus Reviews Issue: Oct. 15, 2013

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THE END OF ILLNESS

Oncologist Agus (Medicine and Engineering/Univ. of Southern California) predicts that the application of advanced technology for modeling complex systems will transform 21st-century medicine.

The author writes that a remark Nobel Laureate Murray Gell-Mann made to him in 2009—“Look at cancer as a system"—transformed the way he views his own specialty and the entire field of preventative medicine. It made him realize that “[r]ather than honoring the body as the exceedingly complex system that it is, we keep looking for the individual gene that has gone awry, or for the one ‘secret’ that can improve our health.” Agus writes that although the ability to sequence the entire human genome is a great step forward, it is insufficient for achieving a significant breakthrough. Even though it may start with a mutation, cancer “is a dynamic process that's happening…far from the confines of a static piece of DNA”—it involves the body's immune system, its ability to regulate cell growth, metabolism and more. Agus directs his university’s Center for Applied Molecular Medicine and is the co-founder of two personalized medicine companies, Applied Proteomics and Navigenics. His hope is that their research will contribute to developing better analytical tools for preventative medicine and for the treatment of cancers. These will address the functioning of the body as a whole, applying digital technology already used by physicists to provide virtual models of cancers and model the action of proteins that regulate cell communication in the body. He also hopes to develop tools that will provide information on the concentration of different proteins in a drop of blood taken from a patient, which may reveal the onset of disease. The author also includes some guiding principles and warnings about certain healthy practices that may not be so healthy. A refreshing change of pace in the medical field, but by venturing beyond his field of expertise to pontificate on a wide range of subjects, Agus makes his otherwise intriguing narrative difficult to follow.  

 

Pub Date: Jan. 1, 2012

ISBN: 978-1-4516-1017-8

Page Count: 288

Publisher: Free Press

Review Posted Online: Nov. 5, 2011

Kirkus Reviews Issue: Nov. 15, 2011

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