A highly optimistic review of anti-aging science that may persuade older readers that they were born too soon.
An uplifting review of the science suggesting that “prolonged healthy lifespans are in sight.”
According to Sinclair (Genetics/Harvard Medical School), scientists have discovered what causes aging. They’ve also discovered how to treat it because, despite what doctors and philosophers have claimed throughout history, aging is not inevitable. It’s a disease. Throughout the book, the author’s enthusiasm jumps off the page. Scientifically inclined readers may be occasionally turned off by his affection for dramatic stories of individuals who defy aging, but they cannot deny that he is an acclaimed, award-winning scientist who works hard to explain his groundbreaking research and that of laboratories around the world. Beginning at the beginning, he writes that “way back in the primordium, the ancestors of every living thing on this planet today evolved to sense DNA damage, slow cellular growth, and divert energy to DNA repair until it was fixed—what I call the survival circuit.” In the 1950s, scientists discovered that DNA damage occurs throughout life. Since it’s disastrous for a cell to divide with broken DNA, repair mechanisms suppress growth and reproduction until they’re finished. Cells that don’t divide live longer. Insects and mice mature quickly, reproduce, and soon die. Elephants and whales grow slowly and live much longer lives. Cells of the bristlecone pine, the oldest of which is nearly 5,000 years old, show no signs of aging. Researchers have discovered the mechanism of growth suppression in hormones and also in genes that produce such specific enzymes. These longevity enhancers respond to stress but also to exercise, intermittent fasting, low-protein and low-calorie diets, and several pharmaceuticals that, the author assures readers, will soon emerge from the laboratory. Also in the works are DNA monitoring and reprogramming, already well advanced in animals, that can detect malfunctions and reset the aging clock.
A highly optimistic review of anti-aging science that may persuade older readers that they were born too soon.Pub Date: Sept. 10, 2019
ISBN: 978-1-5011-9197-8
Page Count: 416
Publisher: Atria
Review Posted Online: June 30, 2019
Kirkus Reviews Issue: July 15, 2019
BOOK REVIEW
Useful but disappointingly commonplace tips.
In a follow-up to The End of Illness (2012), which explored how technological advances will transform medicine, Agus (Medicine and Engineering/Univ. of Southern California) restates time-tested but too often overlooked principles for healthy living.
The author outlines simple measures that average citizens can take to live healthier lives and extend their life spans by taking advantage of modern technology to develop personalized records. These would include a list of medical tests and recommended treatments. Agus also suggests keeping track of indicators that can be observed at home on a regular basis—e.g., changes in energy, weight, appetite and blood pressure, blood sugar and general appearance. He advises that all of this information be made available online, and it is also helpful to investigate family history and consider DNA testing where indicated. Along with maintaining a healthy weight, Agus emphasizes the importance of eating a balanced diet, with plenty of fresh fruits and vegetables and a minimum of red meat. Avoid packaged vitamins and food supplements, and if possible, grow your own vegetables or buy frozen vegetables, which will generally be fresher than those on supermarket shelves. The author also warns against processed foods that make health claims but contain additives or excessive amounts of sugar or fat. Regular mealtimes and plenty of sleep, frequent hand-washing and oral hygiene are a must; smoking and excessive time in the sun should also be avoided. Agus recommends that adults should consider taking statins and baby aspirin as preventative measures. He concludes with a decade-by-decade checklist of annual medical examinations that should be routine—e.g. blood pressure, diabetes and cholesterol screenings, from one’s 20s on; colonoscopies, prostate exams and mammograms later—and a variety of top-10 lists (for example, “Top 10 Reasons to Take a Walk”).
Useful but disappointingly commonplace tips.Pub Date: Jan. 7, 2014
ISBN: 978-1-4767-3095-0
Page Count: 128
Publisher: Simon & Schuster
Review Posted Online: Sept. 30, 2013
Kirkus Reviews Issue: Oct. 15, 2013
BOOK REVIEW
BOOK REVIEW
Oncologist Agus (Medicine and Engineering/Univ. of Southern California) predicts that the application of advanced technology for modeling complex systems will transform 21st-century medicine.
The author writes that a remark Nobel Laureate Murray Gell-Mann made to him in 2009—“Look at cancer as a system"—transformed the way he views his own specialty and the entire field of preventative medicine. It made him realize that “[r]ather than honoring the body as the exceedingly complex system that it is, we keep looking for the individual gene that has gone awry, or for the one ‘secret’ that can improve our health.” Agus writes that although the ability to sequence the entire human genome is a great step forward, it is insufficient for achieving a significant breakthrough. Even though it may start with a mutation, cancer “is a dynamic process that's happening…far from the confines of a static piece of DNA”—it involves the body's immune system, its ability to regulate cell growth, metabolism and more. Agus directs his university’s Center for Applied Molecular Medicine and is the co-founder of two personalized medicine companies, Applied Proteomics and Navigenics. His hope is that their research will contribute to developing better analytical tools for preventative medicine and for the treatment of cancers. These will address the functioning of the body as a whole, applying digital technology already used by physicists to provide virtual models of cancers and model the action of proteins that regulate cell communication in the body. He also hopes to develop tools that will provide information on the concentration of different proteins in a drop of blood taken from a patient, which may reveal the onset of disease. The author also includes some guiding principles and warnings about certain healthy practices that may not be so healthy. A refreshing change of pace in the medical field, but by venturing beyond his field of expertise to pontificate on a wide range of subjects, Agus makes his otherwise intriguing narrative difficult to follow.
Pub Date: Jan. 1, 2012
ISBN: 978-1-4516-1017-8
Page Count: 288
Publisher: Free Press
Review Posted Online: Nov. 5, 2011
Kirkus Reviews Issue: Nov. 15, 2011
BOOK REVIEW
BOOK REVIEW
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