Though increased funding will be difficult to come by, Stipp makes a convincing argument for more widespread anti-aging...
According to former Wall Street Journal science and technology reporter Stipp, scientists are coming close to achieving the goal of using “the powerful new tools of molecular biology” to “shrink death’s dominion.”
Since the turn of the 20th century, the life expectancy of Americans has increased dramatically, thanks to major improvements in sanitation, decreased infant mortality and the introduction of antibiotics, but only now are gerontologists beginning to make significant headway on the causes of aging. In his intriguing debut, Stipp delves into the story that began in the 1930s with the discovery that a calorie-restricted diet increases life expectancy, and continues with the current effort to develop safe drugs that will mimic the effect of a CR diet. The author begins with his 2006 WSJ front-page story about how daily doses of resveratrol, found in red wine, not only protected rodents from the effects of a devastatingly rich diet, but apparently rejuvenated them. Add to this the fact that a genetic mutation causing dwarfism, which suppresses growth hormones, is also a life extender, and the basis for a new comprehensive theory is emerging. A group of genes that normally control the production of cell proteins can be switched to activate cell-repair mechanisms, causing them to absorb the “accumulation of harmful crud…thought to play a major role in aging.” Scientists have now established that the rate of aging in widely diverse organisms is not only amazingly plastic but controllable. The same CR mimetic drugs that are being developed to ward off the ravages of old age can also help counter the effects of obesity. To rival the advances of the 20th century in increased life-expectancy, Stipp estimates that the federal government will need to launch a federal program on par with the 1960s Apollo project. “Sadly,” he writes, “comparative gerontology…has long been one of biomedicine’s poor cousins. Indeed, it’s arguable that most of the lines of research covered in this book are lamentably underfunded.”
Though increased funding will be difficult to come by, Stipp makes a convincing argument for more widespread anti-aging research.Pub Date: July 8, 2010
ISBN: 978-1-61723-000-4
Page Count: 320
Publisher: Current
Review Posted Online: Jan. 19, 2011
Kirkus Reviews Issue: April 15, 2010
Doyle offers another lucid, inspiring chronicle of female empowerment and the rewards of self-awareness and renewal.
More life reflections from the bestselling author on themes of societal captivity and the catharsis of personal freedom.
In her third book, Doyle (Love Warrior, 2016, etc.) begins with a life-changing event. “Four years ago,” she writes, “married to the father of my three children, I fell in love with a woman.” That woman, Abby Wambach, would become her wife. Emblematically arranged into three sections—“Caged,” “Keys,” “Freedom”—the narrative offers, among other elements, vignettes about the soulful author’s girlhood, when she was bulimic and felt like a zoo animal, a “caged girl made for wide-open skies.” She followed the path that seemed right and appropriate based on her Catholic upbringing and adolescent conditioning. After a downward spiral into “drinking, drugging, and purging,” Doyle found sobriety and the authentic self she’d been suppressing. Still, there was trouble: Straining an already troubled marriage was her husband’s infidelity, which eventually led to life-altering choices and the discovery of a love she’d never experienced before. Throughout the book, Doyle remains open and candid, whether she’s admitting to rigging a high school homecoming court election or denouncing the doting perfectionism of “cream cheese parenting,” which is about “giving your children the best of everything.” The author’s fears and concerns are often mirrored by real-world issues: gender roles and bias, white privilege, racism, and religion-fueled homophobia and hypocrisy. Some stories merely skim the surface of larger issues, but Doyle revisits them in later sections and digs deeper, using friends and familial references to personify their impact on her life, both past and present. Shorter pieces, some only a page in length, manage to effectively translate an emotional gut punch, as when Doyle’s therapist called her blooming extramarital lesbian love a “dangerous distraction.” Ultimately, the narrative is an in-depth look at a courageous woman eager to share the wealth of her experiences by embracing vulnerability and reclaiming her inner strength and resiliency.
Doyle offers another lucid, inspiring chronicle of female empowerment and the rewards of self-awareness and renewal.Pub Date: March 10, 2020
ISBN: 978-1-9848-0125-8
Page Count: 352
Publisher: Dial Books
Review Posted Online: Dec. 21, 2019
Kirkus Reviews Issue: Jan. 15, 2020
PROFILES
SEEN & HEARD
SEEN & HEARD
A vibrant, encouraging depiction of a sinister disorder.
A British novelist turns to autobiography to report the manifold symptoms and management of his debilitating disease, depression.
Clever author Haig (The Humans, 2013, etc.) writes brief, episodic vignettes, not of a tranquil life but of an existence of unbearable, unsustainable melancholy. Throughout his story, presented in bits frequently less than a page long (e.g., “Things you think during your 1,000th panic attack”), the author considers phases he describes in turn as Falling, Landing, Rising, Living, and, finally, simply Being with spells of depression. Haig lists markers of his unseen disease, including adolescent angst, pain, continual dread, inability to speak, hypochondria, and insomnia. He describes his frequent panic attacks and near-constant anhedonia, the inability to experience pleasure. Haig also assesses the efficacy of neuroscience, yoga, St. John’s wort, exercise, pharmaceuticals, silence, talking, walking, running, staying put, and working up the courage to do even the most seemingly mundane of tasks, like visiting the village store. Best for the author were reading, writing, and the frequent dispensing of kindnesses and love. He acknowledges particularly his debt to his then-girlfriend, now-wife. After nearly 15 years, Haig is doing better. He appreciates being alive and savors the miracle of existence. His writing is infectious though sometimes facile—and grammarians may be upset with the writer’s occasional confusion of the nominative and objective cases of personal pronouns. Less tidy and more eclectic than William Styron’s equally brief, iconic Darkness Visible, Haig’s book provides unobjectionable advice that will offer some help and succor to those who experience depression and other related illnesses. For families and friends of the afflicted, Haig’s book, like Styron’s, will provide understanding and support.
A vibrant, encouraging depiction of a sinister disorder.Pub Date: Feb. 23, 2016
ISBN: 978-0-14-312872-4
Page Count: 272
Publisher: Penguin
Review Posted Online: Nov. 3, 2015
Kirkus Reviews Issue: Nov. 15, 2015
SEEN & HEARD
Readers Donate Depression Book After Star Suicide
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