This is the full professional biography of two brothers who rose from the ranks of simple country doctors to establish a distinguished and progressive clinic. Their story encompasses the prime medical advances in the late 19th and early 20th centuries, for unlike their colleagues the world over, Dr. Will and Dr. Charlie regarded each innovation with interest rather than suspicion. This tendency to accept rather than reject new data was largely responsible for their great success as surgeons. When Lister discovered antiseptic surgery the Mayos were among the first to adopt it. When Roentgen brought forth the X-ray, the Mayos incorporated it in their diagnostic techniques. Their desire to travel and observe yielded great dividends for they added many complicated operative skills to their growing abilities. From the time Will and Charlie first wedged their way through the patient's uncertainty, following the footsteps of a successful doctor-father, through their years of growth, to their final fame, this reflects the glorious story of ethical and idealistic medicine. There is much to be learned by both the layman and the future doctor from the exceptional experiences and example of the Mayo brothers.