by Ingrid Wickelgren ‧ RELEASE DATE: Nov. 12, 2002
A wonderful lesson on how the march of science is driven by the sheer forces of emotion and motivation as much as by...
From science journalist Wickelgren, the blow-by-blow drama of how government and private enterprise finally came together to (separately) publish their drafts of the human genome.
At first, the thought of doing Big Biology—mapping and sequencing all three billion bases in the human genome—was anathema to scientists, who thought such a project would be tedious, useless, and a waste of time, not to mention a drain on funding for their own projects. But when the Department of Energy bought the idea, National Institutes of Health Director James Wyngaarden wasn’t about to let them run with it. He recruited James Watson to start the ball rolling, but Watson ran into conflict with Wyngaardens’s successor, Bernadine Healy, over the issue of whether the new “expressed sequence tags” that NIH scientist J. Craig Venter was using to trap parts of genes could be patented. Healy liked the idea; Watson scoffed—and left. So did Venter. Healy then wooed Francis Collins to take Watson’s job; Venter set up his own shop with venture capital. For the rest of the decade the battle raged: NIH pursued a conservative approach, while Venter opted for automated gene-sequencing machines and a whole-genome “shotgun” approach, counting on software to string bits of sequence together in the right order. Innovator and gadfly Venter drove Collins up the wall, but he forced NIH to change tactics and speed up. Ultimately, cooler heads (including President Clinton’s) were able to stage a joint White House announcement of the rivals’ genome successes on June 26, 2000. Wickelgren’s account covers the many intricate business arrangements, personality clashes, and cameos of other gene ventures, such as the one that uses Iceland’s population health database to look for genes. She also includes Venter’s recent confession that it was his own genome that his company sequenced.
A wonderful lesson on how the march of science is driven by the sheer forces of emotion and motivation as much as by ingenious ideas.Pub Date: Nov. 12, 2002
ISBN: 0-8050-7174-1
Page Count: 288
Publisher: Henry Holt
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Aug. 15, 2002
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by Lulu Miller illustrated by Kate Samworth ‧ RELEASE DATE: April 14, 2020
A quirky wonder of a book.
A Peabody Award–winning NPR science reporter chronicles the life of a turn-of-the-century scientist and how her quest led to significant revelations about the meaning of order, chaos, and her own existence.
Miller began doing research on David Starr Jordan (1851-1931) to understand how he had managed to carry on after the 1906 San Francisco earthquake destroyed his work. A taxonomist who is credited with discovering “a full fifth of fish known to man in his day,” Jordan had amassed an unparalleled collection of ichthyological specimens. Gathering up all the fish he could save, Jordan sewed the nameplates that had been on the destroyed jars directly onto the fish. His perseverance intrigued the author, who also discusses the struggles she underwent after her affair with a woman ended a heterosexual relationship. Born into an upstate New York farm family, Jordan attended Cornell and then became an itinerant scholar and field researcher until he landed at Indiana University, where his first ichthyological collection was destroyed by lightning. In between this catastrophe and others involving family members’ deaths, he reconstructed his collection. Later, he was appointed as the founding president of Stanford, where he evolved into a Machiavellian figure who trampled on colleagues and sang the praises of eugenics. Miller concludes that Jordan displayed the characteristics of someone who relied on “positive illusions” to rebound from disaster and that his stand on eugenics came from a belief in “a divine hierarchy from bacteria to humans that point[ed]…toward better.” Considering recent research that negates biological hierarchies, the author then suggests that Jordan’s beloved taxonomic category—fish—does not exist. Part biography, part science report, and part meditation on how the chaos that caused Miller’s existential misery could also bring self-acceptance and a loving wife, this unique book is an ingenious celebration of diversity and the mysterious order that underlies all existence.
A quirky wonder of a book.Pub Date: April 14, 2020
ISBN: 978-1-5011-6027-1
Page Count: 224
Publisher: Simon & Schuster
Review Posted Online: Jan. 1, 2020
Kirkus Reviews Issue: Feb. 1, 2020
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by Carlo Rovelli ; translated by Simon Carnell & Erica Segre ‧ RELEASE DATE: March 1, 2016
An intriguing meditation on the nature of the universe and our attempts to understand it that should appeal to both...
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Italian theoretical physicist Rovelli (General Relativity: The Most Beautiful of Theories, 2015, etc.) shares his thoughts on the broader scientific and philosophical implications of the great revolution that has taken place over the past century.
These seven lessons, which first appeared as articles in the Sunday supplement of the Italian newspaper Sole 24 Ore, are addressed to readers with little knowledge of physics. In less than 100 pages, the author, who teaches physics in both France and the United States, cogently covers the great accomplishments of the past and the open questions still baffling physicists today. In the first lesson, he focuses on Einstein's theory of general relativity. He describes Einstein's recognition that gravity "is not diffused through space [but] is that space itself" as "a stroke of pure genius." In the second lesson, Rovelli deals with the puzzling features of quantum physics that challenge our picture of reality. In the remaining sections, the author introduces the constant fluctuations of atoms, the granular nature of space, and more. "It is hardly surprising that there are more things in heaven and earth, dear reader, than have been dreamed of in our philosophy—or in our physics,” he writes. Rovelli also discusses the issues raised in loop quantum gravity, a theory that he co-developed. These issues lead to his extraordinary claim that the passage of time is not fundamental but rather derived from the granular nature of space. The author suggests that there have been two separate pathways throughout human history: mythology and the accumulation of knowledge through observation. He believes that scientists today share the same curiosity about nature exhibited by early man.
An intriguing meditation on the nature of the universe and our attempts to understand it that should appeal to both scientists and general readers.Pub Date: March 1, 2016
ISBN: 978-0-399-18441-3
Page Count: 96
Publisher: Riverhead
Review Posted Online: Dec. 7, 2015
Kirkus Reviews Issue: Dec. 15, 2015
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