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THE CHEMISTRY OF CONSCIOUS STATES

HOW THE BRAIN CHANGES ITS MIND

A prominent neurophysiologist explains his theories about the brain's chemistry and how it affects our conscious (and unconscious) activities. Hobson (Psychiatry/Harvard) espouses a kind of yin-yang view of the brain in which waking states are dominated by ``amines'' (neurotransmitters like norepinephrine that are associated with attention and arousal) and sleeping and vegetative states by acetylcholine. In this hydrodynamic theory amines are depleted as the day wears on and the cholinergic levels rise, precipitating sleep and dreaming—a time when acetylcholine is at its peak. During sleep the system is building up its supply of amines, eventually waking us up. Not altogether a surprising theory, considering that Hobson's first book, The Dreaming Brain and Sleep (not reviewed), reflected similarly his lifelong research into sleep, collection of dream journals, and experiments with lucid (i.e., self-conscious) dreaming. While the notion that we are ruled by our neurochemistry will hardly shock enlightened readers, the tendency in approaches like Hobson's is to overinterpret: Thus the schizophrenic's hallucinations, the fits of expletive-slinging common in Tourette's patients, and the suggestibility of hypnotizable people are all given as examples of involuntary loss of control occurring in waking states (whereas dream sleep creates controls that prevent violent acting out). Curiously, with all the explanatory weight Hobson puts on the importance of sleep and dreaming, he is the first to admit that no one can explain the necessity of dreams; he even suggests that newer drugs that promote production of amines may obviate the need for dreaming. There is obviously more to brain-mind states, more to the bag of neurochemicals and byways of neural circuitry, than Hobson can account for. All the same, his case studies, autobiographical anecdotes, and guidance on how to deal with sleep problems without drugs will intrigue many readers and possibly provide relief to others.

Pub Date: Nov. 1, 1994

ISBN: 0-316-36754-0

Page Count: 336

Publisher: Little, Brown

Review Posted Online: May 19, 2010

Kirkus Reviews Issue: Sept. 1, 1994

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SLEEPERS

An extraordinary true tale of torment, retribution, and loyalty that's irresistibly readable in spite of its intrusively melodramatic prose. Starting out with calculated, movie-ready anecdotes about his boyhood gang, Carcaterra's memoir takes a hairpin turn into horror and then changes tack once more to relate grippingly what must be one of the most outrageous confidence schemes ever perpetrated. Growing up in New York's Hell's Kitchen in the 1960s, former New York Daily News reporter Carcaterra (A Safe Place, 1993) had three close friends with whom he played stickball, bedeviled nuns, and ran errands for the neighborhood Mob boss. All this is recalled through a dripping mist of nostalgia; the streetcorner banter is as stilted and coy as a late Bowery Boys film. But a third of the way in, the story suddenly takes off: In 1967 the four friends seriously injured a man when they more or less unintentionally rolled a hot-dog cart down the steps of a subway entrance. The boys, aged 11 to 14, were packed off to an upstate New York reformatory so brutal it makes Sing Sing sound like Sunnybrook Farm. The guards continually raped and beat them, at one point tossing all of them into solitary confinement, where rats gnawed at their wounds and the menu consisted of oatmeal soaked in urine. Two of Carcaterra's friends were dehumanized by their year upstate, eventually becoming prominent gangsters. In 1980, they happened upon the former guard who had been their principal torturer and shot him dead. The book's stunning denouement concerns the successful plot devised by the author and his third friend, now a Manhattan assistant DA, to free the two killers and to exact revenge against the remaining ex-guards who had scarred their lives so irrevocably. Carcaterra has run a moral and emotional gauntlet, and the resulting book, despite its flaws, is disturbing and hard to forget. (Film rights to Propaganda; author tour)

Pub Date: July 10, 1995

ISBN: 0-345-39606-5

Page Count: 432

Publisher: Ballantine

Review Posted Online: May 19, 2010

Kirkus Reviews Issue: May 1, 1995

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LIFE IS SO GOOD

The memoir of George Dawson, who learned to read when he was 98, places his life in the context of the entire 20th century in this inspiring, yet ultimately blighted, biography. Dawson begins his story with an emotional bang: his account of witnessing the lynching of a young African-American man falsely accused of rape. America’s racial caste system and his illiteracy emerge as the two biggest obstacles in Dawson’s life, but a full view of the man overcoming the obstacles remains oddly hidden. Travels to Ohio, Canada, and Mexico reveal little beyond Dawson’s restlessness, since nothing much happens to him during these wanderings. Similarly, the diverse activities he finds himself engaging in—bootlegging in St. Louis, breaking horses, attending cockfights—never really advance the reader’s understanding of the man. He calls himself a “ladies’ man” and hints at a score of exciting stories, but then describes only his decorous marriage. Despite the personal nature of this memoir, Dawson remains a strangely aloof figure, never quite inviting the reader to enter his world. In contrast to Dawson’s diffidence, however, Glaubman’s overbearing presence, as he repeatedly parades himself out to converse with Dawson, stifles any momentum the memoir might develop. Almost every chapter begins with Glaubman presenting Dawson with a newspaper clipping or historical fact and asking him to comment on it, despite the fact that Dawson often does not remember or never knew about the event in question. Exasperated readers may wonder whether Dawson’s life and his accomplishments, his passion for learning despite daunting obstacles, is the tale at hand, or whether the real issue is his recollections of Archduke Ferdinand. Dawson’s achievements are impressive and potentially exalting, but the gee-whiz nature of the tale degrades it to the status of yet another bowl of chicken soup for the soul, with a narrative frame as clunky as an old bone.

Pub Date: Feb. 1, 2000

ISBN: 0-375-50396-X

Page Count: 288

Publisher: Random House

Review Posted Online: May 19, 2010

Kirkus Reviews Issue: Dec. 15, 1999

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