The human side of research medicine is the focus of this account of three patients participating in clinical trials of new drugs for the treatment of AIDS and cancer. In 1995 and 1996 science writer Kelly (co-author with Thomas Verny of The Secret Life of the Unborn Child, not reviewed) spent some 200 hours with Edward Sandisfield, Romy Hochman, and Julie Conte as they faced life-threatening diseases. Sandisfield, a middle-age gay man knowledgeable about AIDS and its treatment, was so desperate to win a place in the clinical trial at Bellevue of a new protease inhibitor, indivir, in combination with AZT and 3TC, that he was prepared to lie his way into the program if necessary. The Hochmans put their 14-year-old daughter with osteosarcoma (a form of bone cancer that frequently metastasizes to the lungs) into a clinical trial at NYU Medical Center to boost her chances of survival; however, Romy was randomized into the control group, receiving only standard treatment. Conte, a 34-year-old woman with breast cancer, was leery of joining a clinical trial testing a high-dose combination-drug therapy, but having already lost her mother and one sister to the disease, she entered the program at Fox Chase Cancer Center in Pennsylvania. Kelly stayed with his three subjects during exams, interviews, and treatment, observing them and talking to them about their experiences, their hopes, and their fears, and interviewing their families, friends, and doctors. Some conversations seem to be reported verbatim, at times giving the stories an up-close and personal feel. In each, Kelly inserts an essay on the disease and the treatment being tested. While the stories end with all three patients alive, an afterword reveals that by 1997 one had succumbed. Kelly’s discussion of the medicine is thorough, but the portraits of his subjects are uneven. Sandisfield’s story is the most complete and his character and his world the best delineated; by comparison, Conte’s story seems sketchy, and the teenager Hochman remains opaque.
Pub Date: Jan. 12, 1999
ISBN: 0-553-10113-7
Page Count: 352
Publisher: Bantam
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Nov. 15, 1998
An extraordinary true tale of torment, retribution, and loyalty that's irresistibly readable in spite of its intrusively melodramatic prose. Starting out with calculated, movie-ready anecdotes about his boyhood gang, Carcaterra's memoir takes a hairpin turn into horror and then changes tack once more to relate grippingly what must be one of the most outrageous confidence schemes ever perpetrated. Growing up in New York's Hell's Kitchen in the 1960s, former New York Daily News reporter Carcaterra (A Safe Place, 1993) had three close friends with whom he played stickball, bedeviled nuns, and ran errands for the neighborhood Mob boss. All this is recalled through a dripping mist of nostalgia; the streetcorner banter is as stilted and coy as a late Bowery Boys film. But a third of the way in, the story suddenly takes off: In 1967 the four friends seriously injured a man when they more or less unintentionally rolled a hot-dog cart down the steps of a subway entrance. The boys, aged 11 to 14, were packed off to an upstate New York reformatory so brutal it makes Sing Sing sound like Sunnybrook Farm. The guards continually raped and beat them, at one point tossing all of them into solitary confinement, where rats gnawed at their wounds and the menu consisted of oatmeal soaked in urine. Two of Carcaterra's friends were dehumanized by their year upstate, eventually becoming prominent gangsters. In 1980, they happened upon the former guard who had been their principal torturer and shot him dead. The book's stunning denouement concerns the successful plot devised by the author and his third friend, now a Manhattan assistant DA, to free the two killers and to exact revenge against the remaining ex-guards who had scarred their lives so irrevocably. Carcaterra has run a moral and emotional gauntlet, and the resulting book, despite its flaws, is disturbing and hard to forget. (Film rights to Propaganda; author tour)
Pub Date: July 10, 1995
ISBN: 0-345-39606-5
Page Count: 432
Publisher: Ballantine
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: May 1, 1995
BOOK REVIEW
BOOK REVIEW
BOOK REVIEW
The memoir of George Dawson, who learned to read when he was 98, places his life in the context of the entire 20th century in this inspiring, yet ultimately blighted, biography. Dawson begins his story with an emotional bang: his account of witnessing the lynching of a young African-American man falsely accused of rape. America’s racial caste system and his illiteracy emerge as the two biggest obstacles in Dawson’s life, but a full view of the man overcoming the obstacles remains oddly hidden. Travels to Ohio, Canada, and Mexico reveal little beyond Dawson’s restlessness, since nothing much happens to him during these wanderings. Similarly, the diverse activities he finds himself engaging in—bootlegging in St. Louis, breaking horses, attending cockfights—never really advance the reader’s understanding of the man. He calls himself a “ladies’ man” and hints at a score of exciting stories, but then describes only his decorous marriage. Despite the personal nature of this memoir, Dawson remains a strangely aloof figure, never quite inviting the reader to enter his world. In contrast to Dawson’s diffidence, however, Glaubman’s overbearing presence, as he repeatedly parades himself out to converse with Dawson, stifles any momentum the memoir might develop. Almost every chapter begins with Glaubman presenting Dawson with a newspaper clipping or historical fact and asking him to comment on it, despite the fact that Dawson often does not remember or never knew about the event in question. Exasperated readers may wonder whether Dawson’s life and his accomplishments, his passion for learning despite daunting obstacles, is the tale at hand, or whether the real issue is his recollections of Archduke Ferdinand. Dawson’s achievements are impressive and potentially exalting, but the gee-whiz nature of the tale degrades it to the status of yet another bowl of chicken soup for the soul, with a narrative frame as clunky as an old bone.
Pub Date: Feb. 1, 2000
ISBN: 0-375-50396-X
Page Count: 288
Publisher: Random House
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Dec. 15, 1999
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