Davies (editor of the journal Nature Genetics) and White (coauthor, Einstein: A Life in Science, 1994) describe one of the most dramatic discoveries to date regarding the influence of genetic factors on health—the most exciting frontier in medical research. The authors relate the discovery and its background in full detail, providing an effective foundation for understanding not only the process of locating the breast cancer gene but, more generally, the nature and treatment of breast cancer. Cancer is the result of an error in the DNA that regulates normal cell division, caused either by an external agency, such as radiation, or by a congenital ``mistake'' in the DNA. The fact that having close female relatives with breast cancer greatly increaseed a woman's odds of getting the disease indicated that a faulty gene might be active in these cases. By the late 1980s, research zeroed in on a gene designated BRAC1, the chromosomal location of which was announced in 1990 by Dr. Mary Claire-King of the School of Public Health at Berkeley. King's discovery—which the authors compare to narrowing down a search for a missing person from all of North America to New York—set off a race among researchers to pinpoint the precise location of BRAC1. King joined forces with Francis Collins, whose laboratory had isolated the genes responsible for cystic fibrosis and Huntington's disease. But in October 1994, a team headed by Mark Skolnick of the University of Utah isolated the gene. While the discovery does not provide a cure for cancer—or even a clue to one—it may allow women to more accurately assess their own risk. Perhaps in the long run, the discovery will lead to genetic therapy for those women who carry the gene. A well-written and exceptionally detailed overview of the search for the breast cancer gene, spotlighting the breakthrough in its full dramatic impact.
Pub Date: Feb. 16, 1996
ISBN: 0-417-12025-1
Page Count: 320
Publisher: Wiley
Review Posted Online: June 24, 2010
Kirkus Reviews Issue: Dec. 15, 1995
From the national correspondent for PBS's MacNeil-Lehrer Newshour: a moving memoir of her youth in the Deep South and her role in desegregating the Univ. of Georgia. The eldest daughter of an army chaplain, Hunter-Gault was born in what she calls the ``first of many places that I would call `my place' ''—the small village of Due West, tucked away in a remote little corner of South Carolina. While her father served in Korea, Hunter-Gault and her mother moved first to Covington, Georgia, and then to Atlanta. In ``L.A.'' (lovely Atlanta), surrounded by her loving family and a close-knit black community, the author enjoyed a happy childhood participating in activities at church and at school, where her intellectual and leadership abilities soon were noticed by both faculty and peers. In high school, Hunter-Gault found herself studying the ``comic-strip character Brenda Starr as I might have studied a journalism textbook, had there been one.'' Determined to be a journalist, she applied to several colleges—all outside of Georgia, for ``to discourage the possibility that a black student would even think of applying to one of those white schools, the state provided money for black students'' to study out of state. Accepted at Michigan's Wayne State, the author was encouraged by local civil-rights leaders to apply, along with another classmate, to the Univ. of Georgia as well. Her application became a test of changing racial attitudes, as well as of the growing strength of the civil-rights movement in the South, and Gault became a national figure as she braved an onslaught of hostilities and harassment to become the first black woman to attend the university. A remarkably generous, fair-minded account of overcoming some of the biggest, and most intractable, obstacles ever deployed by southern racists. (Photographs—not seen.)
Pub Date: Nov. 1, 1992
ISBN: 0-374-17563-2
Page Count: 192
Publisher: Farrar, Straus and Giroux
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Sept. 1, 1992
Necessarily swift and adumbrative as well as inclusive, focused, and graceful.
A light-speed tour of (mostly) Western poetry, from the 4,000-year-old Gilgamesh to the work of Australian poet Les Murray, who died in 2019.
In the latest entry in the publisher’s Little Histories series, Carey, an emeritus professor at Oxford whose books include What Good Are the Arts? and The Unexpected Professor: An Oxford Life in Books, offers a quick definition of poetry—“relates to language as music relates to noise. It is language made special”—before diving in to poetry’s vast history. In most chapters, the author deals with only a few writers, but as the narrative progresses, he finds himself forced to deal with far more than a handful. In his chapter on 20th-century political poets, for example, he talks about 14 writers in seven pages. Carey displays a determination to inform us about who the best poets were—and what their best poems were. The word “greatest” appears continually; Chaucer was “the greatest medieval English poet,” and Langston Hughes was “the greatest male poet” of the Harlem Renaissance. For readers who need a refresher—or suggestions for the nightstand—Carey provides the best-known names and the most celebrated poems, including Paradise Lost (about which the author has written extensively), “Kubla Khan,” “Ozymandias,” “The Charge of the Light Brigade,” Wordsworth and Coleridge’s Lyrical Ballads, which “changed the course of English poetry.” Carey explains some poetic technique (Hopkins’ “sprung rhythm”) and pauses occasionally to provide autobiographical tidbits—e.g., John Masefield, who wrote the famous “Sea Fever,” “hated the sea.” We learn, as well, about the sexuality of some poets (Auden was bisexual), and, especially later on, Carey discusses the demons that drove some of them, Robert Lowell and Sylvia Plath among them. Refreshingly, he includes many women in the volume—all the way back to Sappho—and has especially kind words for Marianne Moore and Elizabeth Bishop, who share a chapter.
Necessarily swift and adumbrative as well as inclusive, focused, and graceful.Pub Date: April 21, 2020
ISBN: 978-0-300-23222-6
Page Count: 304
Publisher: Yale Univ.
Review Posted Online: Feb. 8, 2020
Kirkus Reviews Issue: March 1, 2020
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