A difficult but rewarding look at a major scientific dispute.

Alzheimer's Disease

HOW ITS BACTERIAL CAUSE WAS FOUND AND THEN DISCARDED

A historical account of the debate over the cause of Alzheimer’s disease.

Alzheimer’s is both debilitating and near ubiquitous; if one lives long enough, Broxmeyer (Autism, 2014, etc.) observes, the odds are high that one will suffer some iteration of it. He also notes that Alois Alzheimer, the scientist after whom the disease is named, likely contributed as much as anyone to the general confusion regarding its precise nature. In 1901, Broxmeyer says, Alzheimer examined Auguste Deter—a woman suffering from diminished memory and behavioral abnormality—and seemed determined to avoid implicating tuberculosis even though the potential link between the two was clear. At the start of the 20th century, TB was troublingly common, but Alzheimer insisted that whatever infectious disease caused the newly discovered malady was itself altogether new. However, the author points out, German neuropathologist Oskar Fischer observed in autopsies that brains addled with Alzheimer’s disease also exhibited a germ associated with TB. Later, it would be discovered that tubercular microbes could generate amyloid fibrils very similar to those found in the Alzheimer’s-related plaques and seemed to affect the brain’s immune cells in the same way. The author is an internist and a medical researcher, and his double mastery of both the scientific minutiae and historical nuances of his subject matter is breathtaking. This is more than an account of a scientific debate—it’s also an examination of the sometimes-unempirical way that such debate proceeds, as it’s conducted by human beings with agendas of their own. The science in this book can be formidably complex, and although Broxmeyer seems to make a concerted effort toward clarity, his work isn’t for the casual layperson. As a result, although it’s a relatively short book—less than 200 pages of text—it is by no means a quick read. Nevertheless, readers with strong science backgrounds will be impressed by the author’s undeniable competence, as well as his journalistic approach to chartering the evolution of thought regarding one of our era’s most challenging diseases.

A difficult but rewarding look at a major scientific dispute.

Pub Date: Aug. 3, 2016

ISBN: 978-1-4912-8735-4

Page Count: 190

Publisher: CreateSpace

Review Posted Online: Sept. 14, 2016

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Stricter than, say, Bergen Evans or W3 ("disinterested" means impartial — period), Strunk is in the last analysis...

THE ELEMENTS OF STYLE

50TH ANNIVERSARY EDITION

Privately published by Strunk of Cornell in 1918 and revised by his student E. B. White in 1959, that "little book" is back again with more White updatings.

Stricter than, say, Bergen Evans or W3 ("disinterested" means impartial — period), Strunk is in the last analysis (whoops — "A bankrupt expression") a unique guide (which means "without like or equal").

Pub Date: May 15, 1972

ISBN: 0205632645

Page Count: 105

Publisher: Macmillan

Review Posted Online: Oct. 28, 2011

Kirkus Reviews Issue: May 1, 1972

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MARTIN LUTHER KING, JR. AND THE MARCH ON WASHINGTON

This early reader is an excellent introduction to the March on Washington in 1963 and the important role in the march played by Martin Luther King Jr. Ruffin gives the book a good, dramatic start: “August 28, 1963. It is a hot summer day in Washington, D.C. More than 250,00 people are pouring into the city.” They have come to protest the treatment of African-Americans here in the US. With stirring original artwork mixed with photographs of the events (and the segregationist policies in the South, such as separate drinking fountains and entrances to public buildings), Ruffin writes of how an end to slavery didn’t mark true equality and that these rights had to be fought for—through marches and sit-ins and words, particularly those of Dr. King, and particularly on that fateful day in Washington. Within a year the Civil Rights Act of 1964 had been passed: “It does not change everything. But it is a beginning.” Lots of visual cues will help new readers through the fairly simple text, but it is the power of the story that will keep them turning the pages. (Easy reader. 6-8)

Pub Date: Jan. 1, 2001

ISBN: 0-448-42421-5

Page Count: 48

Publisher: Grosset & Dunlap

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: Dec. 1, 2000

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