Nesiritide

THE RISE AND FALL OF SCIOS

A cardiology professor–turned–academic consultant and clinical investigator for a pharmaceutical company reveals the way prescription drugs are developed.

In Mills’ (Practical Approaches to the Treatment of Heart Failure, 2001, etc.) part memoir, part scientific account of the way the Food and Drug Administration approves new medications—in this case, a treatment for heart failure called Nesiritide distributed by the “small biotech company” Scios—readers learn how medications are tested and sold. Mills tracks the rise of Scios and its eventual demise. The goal of this cautionary tale, or as Mills terms it, “tragic drama,” is to “instill fear in the audience, the fear of making the same mistake” that his company did. During his time at Scios, Mills engaged “deeply with questions of drug safety and efficacy.” Here, he concisely outlines how Scios went wrong in testing and marketing their now defunct product, from how they worked with the FDA to the press coverage of Scios that was “instrumental in shaping much of the company’s fall” to the Scios management that repeatedly stumbled along the way. Those who work in the pharmaceutical industry or have either an educational or professional interest in understanding how big pharma operates from the inside will glean the most from Mills’ book. He weaves a compelling narrative: he introduces dynamic players like his patient Eddy Buczynski, who suffered from heart failure and was one of the first people to get Mills interested in curing the disease, and later Kim Hillis, the national sales manager at Scios—a “compact blonde dynamo,” who could have been “the star shortstop on a championship softball team.” These descriptions and characters keep what could have been a dry narrative fresh and engaging. A lively, well-told, thoroughly researched look at how drugs are brought to market.

Pub Date: June 18, 2016

ISBN: 978-1-4917-9763-1

Page Count: 150

Publisher: True Directions

Review Posted Online: Dec. 3, 2016

Kirkus Reviews Issue: Jan. 15, 2017

Did you like this book?

No Comments Yet

A tiny book, not much bigger than a pamphlet, with huge potential impact.

Reader Votes

  • Readers Vote
  • 16

Our Verdict

  • Our Verdict
  • GET IT

  • New York Times Bestseller

  • IndieBound Bestseller

NO ONE IS TOO SMALL TO MAKE A DIFFERENCE

A collection of articulate, forceful speeches made from September 2018 to September 2019 by the Swedish climate activist who was nominated for a Nobel Peace Prize.

Speaking in such venues as the European and British Parliaments, the French National Assembly, the Austrian World Summit, and the U.N. General Assembly, Thunberg has always been refreshingly—and necessarily—blunt in her demands for action from world leaders who refuse to address climate change. With clarity and unbridled passion, she presents her message that climate change is an emergency that must be addressed immediately, and she fills her speeches with punchy sound bites delivered in her characteristic pull-no-punches style: “I don’t want you to be hopeful. I want you to panic. I want you to feel the fear I feel every day. And then I want you to act.” In speech after speech, to persuade her listeners, she cites uncomfortable, even alarming statistics about global temperature rise and carbon dioxide emissions. Although this inevitably makes the text rather repetitive, the repetition itself has an impact, driving home her point so that no one can fail to understand its importance. Thunberg varies her style for different audiences. Sometimes it is the rousing “our house is on fire” approach; other times she speaks more quietly about herself and her hopes and her dreams. When addressing the U.S. Congress, she knowingly calls to mind the words and deeds of Martin Luther King Jr. and John F. Kennedy. The last speech in the book ends on a note that is both challenging and upbeat: “We are the change and change is coming.” The edition published in Britain earlier this year contained 11 speeches; this updated edition has 16, all worth reading.

A tiny book, not much bigger than a pamphlet, with huge potential impact.

Pub Date: Nov. 26, 2019

ISBN: 978-0-14-313356-8

Page Count: 112

Publisher: Penguin

Review Posted Online: Nov. 3, 2019

Did you like this book?

A quirky wonder of a book.

WHY FISH DON'T EXIST

A STORY OF LOSS, LOVE, AND THE HIDDEN ORDER OF LIFE

A Peabody Award–winning NPR science reporter chronicles the life of a turn-of-the-century scientist and how her quest led to significant revelations about the meaning of order, chaos, and her own existence.

Miller began doing research on David Starr Jordan (1851-1931) to understand how he had managed to carry on after the 1906 San Francisco earthquake destroyed his work. A taxonomist who is credited with discovering “a full fifth of fish known to man in his day,” Jordan had amassed an unparalleled collection of ichthyological specimens. Gathering up all the fish he could save, Jordan sewed the nameplates that had been on the destroyed jars directly onto the fish. His perseverance intrigued the author, who also discusses the struggles she underwent after her affair with a woman ended a heterosexual relationship. Born into an upstate New York farm family, Jordan attended Cornell and then became an itinerant scholar and field researcher until he landed at Indiana University, where his first ichthyological collection was destroyed by lightning. In between this catastrophe and others involving family members’ deaths, he reconstructed his collection. Later, he was appointed as the founding president of Stanford, where he evolved into a Machiavellian figure who trampled on colleagues and sang the praises of eugenics. Miller concludes that Jordan displayed the characteristics of someone who relied on “positive illusions” to rebound from disaster and that his stand on eugenics came from a belief in “a divine hierarchy from bacteria to humans that point[ed]…toward better.” Considering recent research that negates biological hierarchies, the author then suggests that Jordan’s beloved taxonomic category—fish—does not exist. Part biography, part science report, and part meditation on how the chaos that caused Miller’s existential misery could also bring self-acceptance and a loving wife, this unique book is an ingenious celebration of diversity and the mysterious order that underlies all existence.

A quirky wonder of a book.

Pub Date: April 14, 2020

ISBN: 978-1-5011-6027-1

Page Count: 224

Publisher: Simon & Schuster

Review Posted Online: Jan. 2, 2020

Kirkus Reviews Issue: Feb. 1, 2020

Did you like this book?

more