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PANDORA'S DNA

TRACING THE BREAST CANCER GENES THROUGH HISTORY, SCIENCE, AND ONE FAMILY TREE

A gutsy, deeply revealing account that more than fulfills the promise of the subtitle.

Freelance journalist and author Stark (Leaving Mundania: Inside the Transformative World of Live Action Role-Playing Games, 2012) has both fully researched her subject and poured out her heart in this blend of history, science and memoir.

As the family tree in the book’s front shows, cancer, and the threat of cancer, has plagued the author’s family for generations. When she underwent genetic testing and learned that she had inherited her mother’s BRCA1 mutation, which greatly raises the risks of both breast and ovarian cancers, Stark was well-aware of its significance. After coping with the hassles of close monitoring, she made the tough decision to have a preventative double mastectomy while still in her 20s. The story of that decision and all that follows from it is enough to make a book in itself, but the author goes much further. She provides a capsule history of breast surgery, from the pre-anesthesia days through William Halsted’s now-outdated radical mastectomy to today’s less disfiguring procedures, and she profiles geneticist Mary-Claire King, whose work led to the identification of the BRCA genes. In her discussion of the controversial issue of gene patenting, Stark presents all sides of the argument. Most impressive, she tells her personal story with considerable frankness and flashes of humor. The weekend before her breast-removal surgery, she and her husband threw a “goodbye to boobs” party for their closest friends. That lighthearted moment is followed by less sunny ones as Stark was forced to adjust to her new body and face the questions of whether to bear children and possibly pass on the gene mutation and deciding when to have her threatened ovaries removed. The book is a must-read for women questioning whether to be tested for the BRCA mutations and for women considering their options after testing positive.

A gutsy, deeply revealing account that more than fulfills the promise of the subtitle.

Pub Date: Oct. 15, 2014

ISBN: 978-1613748602

Page Count: 336

Publisher: Chicago Review Press

Review Posted Online: Aug. 26, 2014

Kirkus Reviews Issue: Sept. 15, 2014

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NIGHT

The author's youthfulness helps to assure the inevitable comparison with the Anne Frank diary although over and above the...

Elie Wiesel spent his early years in a small Transylvanian town as one of four children. 

He was the only one of the family to survive what Francois Maurois, in his introduction, calls the "human holocaust" of the persecution of the Jews, which began with the restrictions, the singularization of the yellow star, the enclosure within the ghetto, and went on to the mass deportations to the ovens of Auschwitz and Buchenwald. There are unforgettable and horrifying scenes here in this spare and sombre memoir of this experience of the hanging of a child, of his first farewell with his father who leaves him an inheritance of a knife and a spoon, and of his last goodbye at Buchenwald his father's corpse is already cold let alone the long months of survival under unconscionable conditions. 

The author's youthfulness helps to assure the inevitable comparison with the Anne Frank diary although over and above the sphere of suffering shared, and in this case extended to the death march itself, there is no spiritual or emotional legacy here to offset any reader reluctance.

Pub Date: Jan. 16, 2006

ISBN: 0374500010

Page Count: 120

Publisher: Hill & Wang

Review Posted Online: Oct. 7, 2011

Kirkus Reviews Issue: Jan. 15, 2006

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WHEN BREATH BECOMES AIR

A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular...

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A neurosurgeon with a passion for literature tragically finds his perfect subject after his diagnosis of terminal lung cancer.

Writing isn’t brain surgery, but it’s rare when someone adept at the latter is also so accomplished at the former. Searching for meaning and purpose in his life, Kalanithi pursued a doctorate in literature and had felt certain that he wouldn’t enter the field of medicine, in which his father and other members of his family excelled. “But I couldn’t let go of the question,” he writes, after realizing that his goals “didn’t quite fit in an English department.” “Where did biology, morality, literature and philosophy intersect?” So he decided to set aside his doctoral dissertation and belatedly prepare for medical school, which “would allow me a chance to find answers that are not in books, to find a different sort of sublime, to forge relationships with the suffering, and to keep following the question of what makes human life meaningful, even in the face of death and decay.” The author’s empathy undoubtedly made him an exceptional doctor, and the precision of his prose—as well as the moral purpose underscoring it—suggests that he could have written a good book on any subject he chose. Part of what makes this book so essential is the fact that it was written under a death sentence following the diagnosis that upended his life, just as he was preparing to end his residency and attract offers at the top of his profession. Kalanithi learned he might have 10 years to live or perhaps five. Should he return to neurosurgery (he could and did), or should he write (he also did)? Should he and his wife have a baby? They did, eight months before he died, which was less than two years after the original diagnosis. “The fact of death is unsettling,” he understates. “Yet there is no other way to live.”

A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular clarity.

Pub Date: Jan. 19, 2016

ISBN: 978-0-8129-8840-6

Page Count: 248

Publisher: Random House

Review Posted Online: Sept. 29, 2015

Kirkus Reviews Issue: Oct. 15, 2015

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