A hard-hitting and timely report on a pervasive threat.
Deadly germs escape from advanced laboratories with alarming and perhaps catastrophic consequences, according to this sobering nonfiction book.
Investigative journalist Young, who’s worked as a reporter and editor for such outlets as USA Today, the Detroit Free Press, and the Atlanta Journal-Constitution, explores lapses, accidents, and disasters at high-containment Biosafety Level 2, 3, and 4 laboratories around the world. They include a 1978 smallpox outbreak at a lab at Britain’s Birmingham University that resulted in the world’s last smallpox death (in which the remorseful lab director committed suicide); a 1979 anthrax release from a Soviet bioweapons lab in Sverdlovsk, which killed dozens of people; several leaks of contaminated wastewater at the U.S. Army’s Fort Detrick biological research institute in 2018, which may have traveled to the nearby town of Frederick, Maryland; a lab tech’s death from a bacterial infection in a San Francisco Veterans Administration medical center; several leaks of a SARS-associate coronavirus from Asian labs in 2003 and 2004, resulting in one death; and the exposure of lab workers to engineered microbes during “gain of function” research that seeks to make pathogens more infectious. A lengthy chapter explores the possibility that the Covid-19 pandemic was caused by a virus that escaped from the Wuhan Institute of Virology. Young dives deeply into how lab safeguards can fail because of equipment breakdowns, leaky pipes, holes in biohazard suits, mislabeled vials, accidental needle sticks, and other circumstances. The book also offers an absorbing account of Young’s own dogged reporting as she visits labs (she once found a high-tech containment-lab door sealed shut with duct tape), pries information out of reluctant officials, and receives tips from anonymous sources. She renders scientific issues in lucid, accessible prose that vividly conveys the insidious nature of potentially lethal microbes: “Other liquid or solid particles were so small they became airborne, spreading on invisible air currents, pushed along by heating and cooling systems, the opening and closing of doors, and the movement of people between rooms and down hallways.” Throughout, Young shows just how perilous infectious-disease research can be.
A hard-hitting and timely report on a pervasive threat.Pub Date: April 25, 2023
ISBN: 9781546002932
Page Count: 352
Publisher: Center Street/Hachette
Review Posted Online: Sept. 22, 2023
Kirkus Reviews Issue: Nov. 1, 2023
Review Program: Kirkus Indie
BOOK REVIEW
PERSPECTIVES
A short, smart analysis of perhaps the most famous passage in American history reveals its potency and unfulfilled promise.
Words that made a nation.
Isaacson is known for expansive biographies of great thinkers (and Elon Musk), but here he pens a succinct, stimulating commentary on the Founding Fathers’ ode to “life, liberty, and the pursuit of happiness.” His close reading of the Declaration of Independence’s second sentence, published to mark the 250th anniversary of the document’s adoption, doesn’t downplay its “moral contradiction.” Thomas Jefferson enslaved hundreds of people yet called slavery “a cruel war against human nature” in his first draft of the Declaration. All but 15 of the document’s 56 signers owned enslaved people. While the sentence in question asserted “all men are created equal” and possess “unalienable rights,” the Founders “consciously and intentionally” excluded women, Native Americans, and enslaved people. And yet the sentence is powerful, Isaacson writes, because it names a young nation’s “aspirations.” He mounts a solid defense of what ought to be shared goals, among them economic fairness, “moral compassion,” and a willingness to compromise. “Democracy depends on this,” he writes. Isaacson is excellent when explaining how Enlightenment intellectuals abroad influenced the founders. Benjamin Franklin, one of the Declaration’s “five-person drafting committee,” stayed in David Hume’s home for a month in the early 1770s, “discussing ideas of natural rights” with the Scottish philosopher. Also strong is Isaacson’s discussion of the “edits and tweaks” made to Jefferson’s draft. As recommended by Franklin and others, the changes were substantial, leaving Jefferson “distraught.” Franklin, who emerges as the book’s hero, helped establish municipal services, founded a library, and encouraged religious diversity—the kind of civic-mindedness that we could use more of today, Isaacson reminds us.
A short, smart analysis of perhaps the most famous passage in American history reveals its potency and unfulfilled promise.Pub Date: Nov. 18, 2025
ISBN: 9781982181314
Page Count: 80
Publisher: Simon & Schuster
Review Posted Online: Aug. 29, 2025
Kirkus Reviews Issue: Oct. 1, 2025
BOOK REVIEW
BOOK REVIEW
BOOK REVIEW
SEEN & HEARD
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular...
A neurosurgeon with a passion for literature tragically finds his perfect subject after his diagnosis of terminal lung cancer.
Writing isn’t brain surgery, but it’s rare when someone adept at the latter is also so accomplished at the former. Searching for meaning and purpose in his life, Kalanithi pursued a doctorate in literature and had felt certain that he wouldn’t enter the field of medicine, in which his father and other members of his family excelled. “But I couldn’t let go of the question,” he writes, after realizing that his goals “didn’t quite fit in an English department.” “Where did biology, morality, literature and philosophy intersect?” So he decided to set aside his doctoral dissertation and belatedly prepare for medical school, which “would allow me a chance to find answers that are not in books, to find a different sort of sublime, to forge relationships with the suffering, and to keep following the question of what makes human life meaningful, even in the face of death and decay.” The author’s empathy undoubtedly made him an exceptional doctor, and the precision of his prose—as well as the moral purpose underscoring it—suggests that he could have written a good book on any subject he chose. Part of what makes this book so essential is the fact that it was written under a death sentence following the diagnosis that upended his life, just as he was preparing to end his residency and attract offers at the top of his profession. Kalanithi learned he might have 10 years to live or perhaps five. Should he return to neurosurgery (he could and did), or should he write (he also did)? Should he and his wife have a baby? They did, eight months before he died, which was less than two years after the original diagnosis. “The fact of death is unsettling,” he understates. “Yet there is no other way to live.”
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular clarity.Pub Date: Jan. 19, 2016
ISBN: 978-0-8129-8840-6
Page Count: 248
Publisher: Random House
Review Posted Online: Sept. 29, 2015
Kirkus Reviews Issue: Oct. 15, 2015
PERSPECTIVES
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