A revealing, readable book about “some of competitive capitalism’s most complicated science and most cutthroat marketing...
This follow-up to the author’s book about upstart Vertex Pharmaceuticals (The Billion-Dollar Molecule: One Company’s Quest for the Perfect Drug, 1994) details the firm’s transition from boutique creative group to profitable prescription drug maker.
Business and science writer Werth (Banquet at Delmonico's: Great Minds, the Gilded Age, and the Triumph of Evolution in America, 2009, etc.) offers a blow-by-blow account of visionary Harvard chemist Joshua Boger’s struggle to create a pace-setting drug company to develop breakthrough drugs for serious diseases. Attracted by Vertex’s seemingly quixotic quest to put patients first in an industry dominated by profits and Wall Street, the author once again obtained unusual access to company scientists and officers and followed their passion and work as they shepherded their first drugs through discovery, development and introduction to the marketplace. Covering the years 1993 (Vertex’s fourth year) to 2012, Werth sets his story against controversies facing the massive prescription drug business, most notably public outrage over skyrocketing drug prices. Until 2009, the ambitious, Steve Jobs–like Boger held center stage, determined to make Vertex “Merck, but better,” hiring scientists who “craved the chance to compete at the forefront” and developing new drugs to treat such diseases as rheumatoid arthritis and hepatitis C. Werth provides an inside look at the setting of priorities, the making of deals and partnerships, and the complex, high-risk challenges facing research scientists whose discoveries rarely make it to market. His molecular-level descriptions of drug making will appeal mainly to science-minded readers, but his rendering of bright, quirky individuals and their determination to make Vertex sustainable will satisfy anyone seeking an exciting biotech business story. In 2011, after two decades and more than $3 billion in losses, the Cambridge, Mass.–based company launched a breakthrough drug that combats the leading cause of advanced liver disease.
A revealing, readable book about “some of competitive capitalism’s most complicated science and most cutthroat marketing maneuvers.”Pub Date: Feb. 4, 2014
ISBN: 978-1-4516-5566-7
Page Count: 384
Publisher: Simon & Schuster
Review Posted Online: Dec. 17, 2013
Kirkus Reviews Issue: Jan. 1, 2014
An intriguing meditation on the nature of the universe and our attempts to understand it that should appeal to both...
Italian theoretical physicist Rovelli (General Relativity: The Most Beautiful of Theories, 2015, etc.) shares his thoughts on the broader scientific and philosophical implications of the great revolution that has taken place over the past century.
These seven lessons, which first appeared as articles in the Sunday supplement of the Italian newspaper Sole 24 Ore, are addressed to readers with little knowledge of physics. In less than 100 pages, the author, who teaches physics in both France and the United States, cogently covers the great accomplishments of the past and the open questions still baffling physicists today. In the first lesson, he focuses on Einstein's theory of general relativity. He describes Einstein's recognition that gravity "is not diffused through space [but] is that space itself" as "a stroke of pure genius." In the second lesson, Rovelli deals with the puzzling features of quantum physics that challenge our picture of reality. In the remaining sections, the author introduces the constant fluctuations of atoms, the granular nature of space, and more. "It is hardly surprising that there are more things in heaven and earth, dear reader, than have been dreamed of in our philosophy—or in our physics,” he writes. Rovelli also discusses the issues raised in loop quantum gravity, a theory that he co-developed. These issues lead to his extraordinary claim that the passage of time is not fundamental but rather derived from the granular nature of space. The author suggests that there have been two separate pathways throughout human history: mythology and the accumulation of knowledge through observation. He believes that scientists today share the same curiosity about nature exhibited by early man.
An intriguing meditation on the nature of the universe and our attempts to understand it that should appeal to both scientists and general readers.Pub Date: March 1, 2016
ISBN: 978-0-399-18441-3
Page Count: 96
Publisher: Riverhead
Review Posted Online: Dec. 7, 2015
Kirkus Reviews Issue: Dec. 15, 2015
BOOK REVIEW
BOOK REVIEW
A readable, persuasive argument that our ways of doing business will have to change if we are to prosper—or even survive.
A well-constructed critique of an economic system that, by the author’s account, is a driver of the world’s destruction.
Harvard Business School professor Henderson vigorously questions the bromide that “management’s only duty is to maximize shareholder value,” a notion advanced by Milton Friedman and accepted uncritically in business schools ever since. By that logic, writes the author, there is no reason why corporations should not fish out the oceans, raise drug prices, militate against public education (since it costs tax money), and otherwise behave ruinously and anti-socially. Many do, even though an alternative theory of business organization argues that corporations and society should enjoy a symbiotic relationship of mutual benefit, which includes corporate investment in what economists call public goods. Given that the history of humankind is “the story of our increasing ability to cooperate at larger and larger scales,” one would hope that in the face of environmental degradation and other threats, we might adopt the symbiotic model rather than the winner-take-all one. Problems abound, of course, including that of the “free rider,” the corporation that takes the benefits from collaborative agreements but does none of the work. Henderson examines case studies such as a large food company that emphasized environmentally responsible production and in turn built “purpose-led, sustainable living brands” and otherwise led the way in increasing shareholder value by reducing risk while building demand. The author argues that the “short-termism” that dominates corporate thinking needs to be adjusted to a longer view even though the larger problem might be better characterized as “failure of information.” Henderson closes with a set of prescriptions for bringing a more equitable economics to the personal level, one that, among other things, asks us to step outside routine—eat less meat, drive less—and become active in forcing corporations (and politicians) to be better citizens.
A readable, persuasive argument that our ways of doing business will have to change if we are to prosper—or even survive.Pub Date: May 1, 2020
ISBN: 978-1-5417-3015-1
Page Count: 336
Publisher: PublicAffairs
Review Posted Online: Feb. 16, 2020
Kirkus Reviews Issue: March 15, 2020
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