An impassioned but unconvincing argument for a medical treatment.
A urologist proposes a new approach to treating aging in women.
In this follow-up to Ageless Man (2017), Debled theorizes that many of the negative symptoms that are associated with aging and menopause in women can be attributed to a decline in testosterone production. The book reviews clinical evidence for such a decrease in testosterone and other hormones, and it goes on to draw connections between lower hormone levels and symptoms generally associated with menopause and aging, including muscle loss, Type 2 diabetes, and cardiovascular disease. Debled discusses each symptom in detail and talks about how it may be the result of androgen deficiency. As the book addresses existing research, it also makes suggestions for new areas of study with a focus on androgenic hormones in women. Debled concludes that the aforementioned physical conditions, which he calls the “androgenic diseases of menopause,” can be best treated with mesterolone supplements, though he acknowledges that mesterolone is not approved for use in the United States. He also discusses ways in which standard hormone replacement therapy, with its focus on estrogen and progesterone, is harmful. Over the course of this book, Debled presents a thought-provoking interpretation of clinical evidence that runs counter to accepted scientific practice. However, he doesn’t make a convincing case for his fundamental upending of conventional wisdom. Readers who are inclined to treat women’s aging as a natural process are sure to find the author’s perspective challenging. Throughout, Debled treats the symptoms of aging as extremely negative (“If you are over forty, don’t you believe yourself to be sick?”). In particular, he presents them as distasteful from an aesthetic perspective; his descriptions of older women (“Old, frustrated obese women often deploy ingenuity and diet-program calculations, generally without result”) are extremely unflattering. In addition, the book’s description of women’s sex organs as their “male genitalia,” because they respond to androgens, isn’t linguistically or conceptually standard.
The goal of the author’s method of treatment is the elimination of aging (“mature human beings will no longer know the inexorable decrepitude that leads to death at around age eighty”). To that end, Debled generally does a good job of explaining physiology in chapters detailing conditions associated with getting older and how they may be connected to decreases in hormone production. In the book’s conclusion, he links his advocacy of mesterolone treatment to an episode in his past, when his approach to treating impotence resulted in the end of his teaching career and his establishment of a private clinic. The observations and recommendations in this book are based on the author’s work there, which includes the use of mesterolone. The book does include research citations, although readers should be advised that many of the papers are in French and refer to Debled’s own work. The book is enthusiastic about reevaluating the aging process, but it does not provide enough evidence to persuade readers to try the treatment that it endorses, which isn’t approved by U.S. government regulators.
An impassioned but unconvincing argument for a medical treatment.Pub Date: June 29, 2020
ISBN: N/A
Page Count: 308
Publisher: Self
Review Posted Online: Dec. 8, 2020
Review Program: Kirkus Indie
BOOK REVIEW
A delightful exploration of traditional foods as well as a grim warning that we are farming on borrowed time.
Fascinating descriptions of Indigenous and mostly disappearing foods, plus an alarming message.
Veteran BBC food journalist Saladino emphasizes that world food production exploded after World War II when scientists produced superproductive grains, plants, and livestock. Though these developments drastically reduced famine, the mechanics involved require enormous inputs of chemicals, fertilizer, and water. Relying on elite, high-yield species eliminated those that didn’t measure up, diminishing their diversity. Today, rice, wheat, and corn provide half of all human calories. Most global pork comes from a single breed of pig, and more than 95% of U.S. dairy cows are a single breed, the Holstein. Limiting food diversity has been enormously profitable for large corporations, but the future consequences make scientists uneasy. “We are living and eating our way through one big unparalleled experiment,” writes the author. Having defined the problem, Saladino chronicles his travels around the world, describing dozens of vanishing edibles and pausing regularly to deliver the history of the major foods and food production. Readers will be intrigued and educated by his interviews with experts who warn of our disastrous dependence on a shrinking number of standardized foods. Commercial barley can’t survive in the cold, infertile islands north of Scotland, but its ancestral variety does fine. Although nearing extinction in the wild, Atlantic salmon is a familiar food item because almost all of them are farm raised. Bred to be faster growing and meatier, they have become a bland domestic food animal no less than the chicken or cow. Though there are more than 1,500 varieties of banana, most markets are dominated by the Cavendish, a cloned fruit grown in immense monocultures visible by satellite. Being genetically identical, they can’t evolve and so can’t develop resistance to disease, which inevitably spreads like wildfire. One specific disease is currently devastating the Cavendish, but scientists are working to edit the plant’s DNA “to find a fix against the disease.”
A delightful exploration of traditional foods as well as a grim warning that we are farming on borrowed time.Pub Date: Jan. 25, 2022
ISBN: 978-0-374-60532-2
Page Count: 464
Publisher: Farrar, Straus and Giroux
Review Posted Online: Oct. 25, 2021
Kirkus Reviews Issue: Nov. 15, 2021
SEEN & HEARD
Eight brief chronicles of medical detection by the late RouechÇ (Sea to Shining Sea, 1986, etc.), whose ``Annals of Medicine'' pieces in the New Yorker established him as a master of the genre. Readers familiar with RouechÇ's work will know just what to expect here and will not be disappointed. Patients' identities are concealed, but the doctors are identified, and RouechÇ's style of quoting them at length gives his accounts authenticity and immediacy. What's remarkable is the variety of cases he explores. In the title story, the puzzle to be solved is the sudden growth of breasts in a male patient in his 70s. Surprisingly, it is the patient's wife, not his doctor, who comes up with the solution. ``The Dinosaur Collection'' features a case of Munchausen's Syndrome (the faking of illness), the twist here being that the deception is perpetrated not by the patient but by his mother. ``Cinnabar'' and ``A Good Safe Tan'' deal with the known and unknown poisons in our midst. The first features an artist repairing an ancient tapestry, and the second, a young girl who consumes what she believes is a harmless vegetable dye in the hopes of acquiring a glorious tan. Vanity also comes into play in ``Hoping,'' in which a young woman's desire for slim thighs leads her to a hospital emergency room. A doctor working in a little-known specialty, the medical problems of musicians, is the chief sleuth in ``Overdoing It.'' ``The Poker Room'' is a classic RouechÇ detection piece involving an outbreak of Q fever, a long-running poker game, and a litter of kittens. The final piece, ``Hoofbeats of a Zebra,'' demonstrates that sometimes when one hears hoofbeats, it is not the common horse that should be expected, but the uncommon zebra, i.e., the rare disease. A great treat for fans of medical lore.
Pub Date: May 15, 1995
ISBN: 0-525-93934-2
Page Count: 192
Publisher: Dutton
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: March 1, 1995
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