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TYRANNY OF THE GENE

PERSONALIZED MEDICINE AND ITS THREAT TO PUBLIC HEALTH

An engaging, provocative study of a much-hyped aspect of American health care.

A history and debunking of the health sciences’ embrace of precision medicine rooted in genetics.

Tabery, a professor of philosophy and health ethics, argues that the role of genetic research in a fundamental transformation of health care in America was not inevitable. In fact, he suggests, its promise of tailored medicine was not even all that revolutionary, and its current achievements are mostly exaggerated. To make his point, the author investigates the Human Genome Project and the scientists involved as they edged out the opposing environmental approach embodied in the National Children’s Study that fought—unsuccessfully—for more than a decade to offer an alternative data set. In an accessible narrative bolstered by prodigious research, Tabery reveals that victory for genomics was less about hard science and more about business interests, media fascination, and political leverage. The author admits his own belief in the superiority of the environmental approach, its attention to the social determinants of health, and its emphasis on prevention. However, Tabery does more to poke holes in the genetic approach than to validate the effectiveness of the environmental one, and comprehensive, detailed backstories are occasionally digressive and detract from the author’s primary argument. Still, even these details and the way they connect various scientific innovations serve to underscore concerns about how biological information is used, how quickly private industry and political interests can undermine the scientific community, and how cavalierly genetic medicine can play with patient expectations. Tabery succeeds in raising a compelling alarm about where things stand and making clear that the current situation could have been much different, all while laying the groundwork for an alternative future that better solves the disparities that personalized medicine has ignored—and, in some cases, exacerbated. The debates will continue, but the author provides a solid resource within that debate.

An engaging, provocative study of a much-hyped aspect of American health care.

Pub Date: Aug. 15, 2023

ISBN: 9780525658207

Page Count: 336

Publisher: Knopf

Review Posted Online: May 27, 2023

Kirkus Reviews Issue: June 15, 2023

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ABUNDANCE

Cogent, well-timed ideas for meeting today’s biggest challenges.

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  • New York Times Bestseller

Helping liberals get out of their own way.

Klein, a New York Times columnist, and Thompson, an Atlantic staffer, lean to the left, but they aren’t interrogating the usual suspects. Aware that many conservatives have no interest in their opinions, the authors target their own side’s “pathologies.” Why do red states greenlight the kind of renewable energy projects that often languish in blue states? Why does liberal California have the nation’s most severe homelessness and housing affordability crises? One big reason: Liberal leadership has ensnared itself in a web of well-intentioned yet often onerous “goals, standards, and rules.” This “procedural kludge,” partially shaped by lawyers who pioneered a “democracy by lawsuit” strategy in the 1960s, threatens to stymie key breakthroughs. Consider the anti-pollution laws passed after World War II. In the decades since, homeowners’ groups in liberal locales have cited such statutes in lawsuits meant to stop new affordable housing. Today, these laws “block the clean energy projects” required to tackle climate change. Nuclear energy is “inarguably safer” than the fossil fuel variety, but because Washington doesn’t always “properly weigh risk,” it almost never builds new reactors. Meanwhile, technologies that may cure disease or slash the carbon footprint of cement production benefit from government support, but too often the grant process “rewards caution and punishes outsider thinking.” The authors call this style of governing “everything-bagel liberalism,” so named because of its many government mandates. Instead, they envision “a politics of abundance” that would remake travel, work, and health. This won’t happen without “changing the processes that make building and inventing so hard.” It’s time, then, to scrutinize everything from municipal zoning regulations to the paperwork requirements for scientists getting federal funding. The authors’ debut as a duo is very smart and eminently useful.

Cogent, well-timed ideas for meeting today’s biggest challenges.

Pub Date: March 18, 2025

ISBN: 9781668023488

Page Count: 320

Publisher: Avid Reader Press

Review Posted Online: Jan. 16, 2025

Kirkus Reviews Issue: Feb. 15, 2025

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THE JAILHOUSE LAWYER

An eye-opening look at prison life from the point of view of a true warrior for justice.

A memoir on the making of a literal “jailhouse lawyer.”

Wrongfully arrested and convicted of murder in New Orleans, which at the time had “the highest rate of wrongful convictions in the nation, with nearly all the victims being Black men who…grew up poor,” Duncan served for 23 years in Louisiana’s notorious Angola prison and other institutions. He might have done his time at the Orleans Parish Prison, but, he writes, he wanted access to Angola’s more extensive law library. Well before being transferred there, he petitioned the Louisiana Supreme Court for a law book, a motion denied because it had not first been adjudicated in a lower court. A sympathetic judge gave him a copy all the same, and Duncan was off to a career as an inmate advocate, regularly filing petitions and lawsuits on his own behalf and that of his fellow prisoners—the first suit being “over the jail’s failure to provide him with a high-fiber diet,” soon followed by motions to provide mental health treatment, end beatings and arbitrary punishments, and improve medical care. Known as the “Snickers Lawyer” for taking payment in candy, he became a self-taught expert on constitutional issues. Naturally, he recounts, he was targeted by guards and wardens for his legal activism, even as he proved essential to Angola’s population; in time, too, he found a few unlikely allies among the staff. Duncan’s well-told story is full of fraught moments of abuse both physical and judicial, though it has something of a happy ending in that, after earning a law degree after his release, he was exonerated of the crime and has since been fighting for other prisoners to “have meaningful access to the courts.”

An eye-opening look at prison life from the point of view of a true warrior for justice.

Pub Date: July 8, 2025

ISBN: 9780593834305

Page Count: 400

Publisher: Penguin Press

Review Posted Online: April 17, 2025

Kirkus Reviews Issue: May 15, 2025

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