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PANDORA'S DNA

TRACING THE BREAST CANCER GENES THROUGH HISTORY, SCIENCE, AND ONE FAMILY TREE

A gutsy, deeply revealing account that more than fulfills the promise of the subtitle.

Freelance journalist and author Stark (Leaving Mundania: Inside the Transformative World of Live Action Role-Playing Games, 2012) has both fully researched her subject and poured out her heart in this blend of history, science and memoir.

As the family tree in the book’s front shows, cancer, and the threat of cancer, has plagued the author’s family for generations. When she underwent genetic testing and learned that she had inherited her mother’s BRCA1 mutation, which greatly raises the risks of both breast and ovarian cancers, Stark was well-aware of its significance. After coping with the hassles of close monitoring, she made the tough decision to have a preventative double mastectomy while still in her 20s. The story of that decision and all that follows from it is enough to make a book in itself, but the author goes much further. She provides a capsule history of breast surgery, from the pre-anesthesia days through William Halsted’s now-outdated radical mastectomy to today’s less disfiguring procedures, and she profiles geneticist Mary-Claire King, whose work led to the identification of the BRCA genes. In her discussion of the controversial issue of gene patenting, Stark presents all sides of the argument. Most impressive, she tells her personal story with considerable frankness and flashes of humor. The weekend before her breast-removal surgery, she and her husband threw a “goodbye to boobs” party for their closest friends. That lighthearted moment is followed by less sunny ones as Stark was forced to adjust to her new body and face the questions of whether to bear children and possibly pass on the gene mutation and deciding when to have her threatened ovaries removed. The book is a must-read for women questioning whether to be tested for the BRCA mutations and for women considering their options after testing positive.

A gutsy, deeply revealing account that more than fulfills the promise of the subtitle.

Pub Date: Oct. 15, 2014

ISBN: 978-1613748602

Page Count: 336

Publisher: Chicago Review Press

Review Posted Online: Aug. 26, 2014

Kirkus Reviews Issue: Sept. 15, 2014

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REASONS TO STAY ALIVE

A vibrant, encouraging depiction of a sinister disorder.

A British novelist turns to autobiography to report the manifold symptoms and management of his debilitating disease, depression.

Clever author Haig (The Humans, 2013, etc.) writes brief, episodic vignettes, not of a tranquil life but of an existence of unbearable, unsustainable melancholy. Throughout his story, presented in bits frequently less than a page long (e.g., “Things you think during your 1,000th panic attack”), the author considers phases he describes in turn as Falling, Landing, Rising, Living, and, finally, simply Being with spells of depression. Haig lists markers of his unseen disease, including adolescent angst, pain, continual dread, inability to speak, hypochondria, and insomnia. He describes his frequent panic attacks and near-constant anhedonia, the inability to experience pleasure. Haig also assesses the efficacy of neuroscience, yoga, St. John’s wort, exercise, pharmaceuticals, silence, talking, walking, running, staying put, and working up the courage to do even the most seemingly mundane of tasks, like visiting the village store. Best for the author were reading, writing, and the frequent dispensing of kindnesses and love. He acknowledges particularly his debt to his then-girlfriend, now-wife. After nearly 15 years, Haig is doing better. He appreciates being alive and savors the miracle of existence. His writing is infectious though sometimes facile—and grammarians may be upset with the writer’s occasional confusion of the nominative and objective cases of personal pronouns. Less tidy and more eclectic than William Styron’s equally brief, iconic Darkness Visible, Haig’s book provides unobjectionable advice that will offer some help and succor to those who experience depression and other related illnesses. For families and friends of the afflicted, Haig’s book, like Styron’s, will provide understanding and support.

A vibrant, encouraging depiction of a sinister disorder.

Pub Date: Feb. 23, 2016

ISBN: 978-0-14-312872-4

Page Count: 272

Publisher: Penguin

Review Posted Online: Nov. 3, 2015

Kirkus Reviews Issue: Nov. 15, 2015

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DECISION POINTS

Honest, of course, but also surprisingly approachable and engaging.

W. has his say.

In a page-turner structured around important decisions in his life and presidency, Bush surprises with a lucid, heartfelt look back. Despite expected defenses of past decisions, Bush is candid and unafraid to say when he thinks he was wrong. Critics on both the left and right are challenged to walk in his shoes, and may come away with a new view of the former president—or at least an appreciation of the hard and often ambiguous choices he was forced to make. Aside from the opening chapter about his decision to quit drinking, the book is not chronologically ordered. Bush mixes topics as needed to tell a larger story than a simple history of his administration. Certain themes dominate the narrative: the all-encompassing importance of 9/11 to the bulk of his presidency, and how it shaped and shadowed almost everything he did; the importance of his faith, which is echoed in every chapter and which comes through in an unassuming manner; the often unseen advisor whom the president conferred with and confided in on almost every subject—his wife, Laura Bush; and the wide array of people who helped him rise to the White House and then often hindered him once he was there. The book is worthwhile for many reasons. Even if many readers may not agree with his views on the subjects, Bush’s memories of 9/11, Hurricane Katrina and other major events are riveting and of historical value on their own. Additionally, Bush provides insight into the daily life of the president. The author accepts blame for a number of mistakes and misjudgments, while also standing up for decisions he felt were right.

Honest, of course, but also surprisingly approachable and engaging.

Pub Date: Nov. 9, 2010

ISBN: 978-0-307-59061-9

Page Count: 512

Publisher: Crown

Review Posted Online: Dec. 23, 2010

Kirkus Reviews Issue: Dec. 15, 2010

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