The nature of a so-called second brain in the gut is revealed in exquisite detail by a neurogastroenterologist who has spent some 30 years researching the subject. Gershon, professor of anatomy and cell biology at New York’s Columbia-Presbyterian Medical Center, is enthralled by the sophistication of the enteric nervous system. He calls this system, which operates the bowel, a second brain, pointing out that it contains all the classes of neurotransmitters found in the brain. For nonbiologists entering his world, a whole new vocabulary with terms like neural crest, 5-HT1P receptor, and functional ligand must be acquired. While the terminology can be daunting and the exhaustive details sometimes overwhelming, Gershon has wisely included lots of clear line drawings to help the novice understand the nervous system and the complexities of the digestive system that it runs. Happily, he also tells his story in human terms, paying homage to those whose discoveries enabled his own, good-humoredly sharing the exhilaration of jousting with colleagues over his theories, and generously describing the skills and inventiveness of researchers in his own laboratory and those of other neurobiologists. As this research sheds light on how the “brain in the belly” controls the behavior of the bowel, progress can be expected in the prevention, treatment, and control of gastrointestinal disease. When patients present with gastrointestinal problems for which doctors can find no specific cause, too often they are dismissed as neurotic complainers. That answers may be found in the enteric nervous system offers new hope for the 20 percent of Americans diagnosed with functional bowel disorders. An authoritative work that makes abundantly clear the value of basic research; unfortunately, it’s encumbered with an intimidating amount of technical detail that may discourage interested readers.
Pub Date: Oct. 28, 1998
ISBN: 0-06-018252-0
Page Count: 256
Publisher: HarperCollins
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Sept. 1, 1998
An informal, first-person account of the discovery of a genetic link to male homosexuality by a scientist who has given thought to the ramifications of his findings. With the help of Scripps-Howard journalist Copeland, Hamer, a molecular geneticist who heads the National Cancer Institute's section on gene structure and regulation, describes in just the right amount of detail how he put together his research project on homosexuality. He relates how he obtained approval, funding, a research team, and a place to work; how he found the volunteers he needed (gay brothers willing to give blood samples and answer a lot of very personal questions); and what he learned from them and their family trees. Genetics being a statistical science, there's a fair amount of discussion of statistical techniques, but happily this is mostly presented with the general reader in mind. Hamer's account offers a glimpse into both the collegiality and the politics of science, and there's a delightful chapter on a confrontation he had at Harvard with critics of his research. The final portion of his book presents theories about how genes may influence sexual behavior and other human attributes and speculation about the implication of his research. In July 1993, in the midst of intense public debate over gays in the military, the journal Science published Hamer's paper, ``A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation.'' Tabloids and TV talk shows took it from there. Hamer does not dwell on his time in the spotlight, but the experience evidently sharpened his awareness of public concerns and misconceptions. After noting the possible misuses of genetic research, Hamer concludes that the real danger lies in not studying sex at all. Appendixes include the Science article (not seen) and the interview questionnaire used with research participants. Nothing to titillate, but plenty to think about. (Illustrations, not seen) (Author tour)
Pub Date: Oct. 1, 1994
ISBN: 0-671-88724-6
Page Count: 320
Publisher: Simon & Schuster
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Aug. 1, 1994
BOOK REVIEW
BOOK REVIEW
An analysis that will appeal more to engineers than to behaviorists and psychologists: informative, but with a relatively...
Leading neuroscientist Montague takes a biomechanical approach to explain the mental processes that occur in decision-making.
Like computers, the human brain processes data and produces a result—but with a twist, declares the author. The gray area of computational neuroscience lies in the value judgments that occur in biological systems. Nature, Montague posits in his debut, has equipped the biological machine with the added ability to determine the significance of a computation. Moreover, by storing these valuations as a byproduct of computation, the mind adapts and becomes increasingly more efficient. Repeated exposure to a typical risk-reward scenario, for example, causes the mind to anticipate outcomes. Montague revisits many of the old “right-brain” scenarios with a “left-brain” approach. With a graduate student, he replicated the famous “Pepsi Challenge” and found no relationship between the drink selected in the test and the drinks that subjects actually purchased in the stores. Though Montague’s research is thorough, his explanations vary from wry to impenetrably abstract, and the definition of value remains elusive. Value may be a burst of dopamine, a goal created from a pattern of inputs from the environment, an abstract emotion such as trust, or anything in-between. The essence of Montague’s work is that biological machines assign a value “tag” to each piece of data that they process. Whether tiny bacteria or human being, this is what differentiates us from the machines we create. The “soul” of the human machine may be the sum of these value tags. The answer to the titular question is itself a value judgment based on individual experience.
An analysis that will appeal more to engineers than to behaviorists and psychologists: informative, but with a relatively narrow audience.Pub Date: Nov. 2, 2006
ISBN: 0-525-94982-8
Page Count: 240
Publisher: Dutton
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Aug. 1, 2006
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