A condensed version of Westfall's 1981 biography of Newton, Never at Rest (priced at $100 and not reviewed), that nevertheless displays a high level of scholarship and detail. Westfall (History and Philosophy of Science/Indiana University) clearly has pored over the letters and papers that accumulated over Newton's 83-year lifetime (1642-1727), including the theological and alchemical writings as well as the all- important Opticks and Principia. There's a presumption that the reader appreciates the revolution in science wrought by Newton, and the fundamental philosophical disputes between him and his contemporaries: Newton raging against the Cartesians with all their hypothetical and vortex-ridden speculations in contrast to his own theory-grounded-in-experiment approach. But while one can acknowledge the genius that was Newton, not even Westfall—with his consummate understanding, fair-mindedness, and sympathy—can make the man lovable. There are of course, the circumstances of the scientist's life: His father died before he was born, and, when he was three, his mother remarried, leaving the boy to be raised by his maternal grandparents. Without undue emphasis on Freud, Westfall makes clear that such beginnings contributed to the loneliness and isolation, the neuroses, obsessions, and paranoia that characterized the life. The maligning of Robert Hooke, the undermining of the astronomer Flamsteed, and the vicious attack on Leibniz over priority in the invention of calculus add nothing to Newton's luster. Still, the scientist mellowed in the end. He presided over the Royal Society, gained income from his position at the Mint, was generous to his many relatives, and enjoyed the company of his remarkable niece in his house in London. On his deathbed, Newton refused the sacraments, confirming his lifelong anti-Trinitarianism (which could not otherwise be revealed in public). An altogether admirable job of scholarship, whose weightiness is balanced by the surfacing, from time to time, of Westfall's dry humor. (Six halftones; nine line drawings.)
Pub Date: April 1, 1993
ISBN: 0-521-43252-9
Page Count: 325
Publisher: Cambridge Univ.
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Feb. 1, 1993
Why sex? It's for repair, stupid. Michod (Ecology and Evolutionary Biology/Univ. of Arizona) says that sex is not for diversity in the gene pool (the conventional wisdom), but rather to repair genetic damage and rid the genome of unwanted mutations. Remember all that business you learned in biology about sexual division (meiosis), that complicated process by which chromosomes split various times, then come together at fertilization to produce an offspring with genes from all four grandparents? Well, that certainly makes for diversity, argues Michod, but it's secondary to keeping the gene lineage pure: That chromosome activity can repair damage. In defense of this provocative idea, the author reviews the course of evolution from asexual and sexual reproduction in single cells on to complex organisms, explaining the increasingly sophisticated means by which DNA replication is controlled and mistakes are corrected. Using mathematical models and examples drawn from nature he illustrates the high cost of sex (energy consumed in searching and wooing, chance of disease, etc.) to demonstrate that sex must be doing something vital. That something turns out to be preserving the genome. Shades of Richard Dawkins (The Selfish Gene, 1977): Sex is not for the pleasure of thee and me, it's just the genes' way not only of making other genes but of making sure those genes are clean. Michod attempts to clarify by way of diagrams and chapter notes that may challenge the general reader, as does his soaring last chapter, in which he argues for both the unity of life and the distinctiveness of species. No doubt many will respond that there must be more to sex than repair, and some will raise the issue of such phenomena as transduction in bacteria and viral infection as ways in which nature mixes genomes for better or worse. But Michod's ideas surely merits a hearing. Sure to spark a lively debate.
Pub Date: Feb. 1, 1995
ISBN: 0-201-40754-X
Page Count: 256
Publisher: Addison-Wesley
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Nov. 15, 1994
Some surprising answers to questions about why our bodies are designed the way they are and why we get the diseases we do. Nesse, a physician (Psychiatry/Univ. of Michigan) and Williams (Ecology and Evolution/SUNY, Stony Brook) first teamed up to write an article on Darwinian medicine, which applies the concept of adaptation by natural selection to medical questions. That article, published in 1991 in The Quarterly Review of Biology, has been expanded into the present book, in which the authors look at the design characteristics of the human body that make it susceptible to disease. Their conclusions? First, sometimes it's our genes that make us vulnerable to disease. Some genetic defects arise through mutations, but more often, genes with deleterious effects are maintained through natural selection because their benefits outweigh their costs. Second, there's a mismatch between our present environment and the one that over thousands of years shaped our hunter-gatherer ancestors. There simply hasn't been time for our bodies to adapt, and we suffer the consequences. Third, disease results from design compromises. For example, the structural changes that allowed us to develop from horizontal four-footed creatures to upright two-footed ones left us vulnerable to back problems. Fourth, our evolutionary history has left us some troublesome legacies, such as the unfortunate intersection in our throats of the passages for food and air. Some of the areas Nesse and Williams apply their Darwinian approach to are infectious diseases, allergies, cancer, aging, reproduction, and mental disorders. Happily, they write with impeccable clarity, and when they are speculating (which they do freely), they are careful to say so. They also offer numerous suggestions for research studies, thoughtful proposals for reshaping medical textbooks and medical education, and a scenario dramatizing Darwinian medicine's possible clinical application. Fascinating reading for doctors and patients alike.
Pub Date: Jan. 1, 1995
ISBN: 0-8129-2224-7
Page Count: 288
Publisher: Times/Henry Holt
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Nov. 15, 1994
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