A meticulous and thoughtful scientific exploration.
A thorough tour of the science of depression, including its causes and its treatment.
Motivated to understand the suicidal depression that plagued a close friend, debut author Zabel, a retired major general in the U.S. Air Force, delved deeply into the constantly evolving research, hoping to find answers. The result is this remarkably comprehensive assessment of the competing theories regarding the reasons for depression, and of its therapeutic treatment. The author lucidly chronicles the shifting expert consensus on depression, from its interpretation as a trauma response to its acknowledgement as a biologically based illness. The candidate causes, however, are many. Is it the result of a chemical deficiency, or an excess of inflammation, or is it a function of cellular energy metabolism? One promising theory, the author notes, views depression as a stultification of neuroplasticity; a brain is in the continuous throes of “abrasion” and repair, and depression may result when the effects of the former surpass the latter’s. Zabel’s study is breathtakingly expansive—she looks at epidemiological surveys of a range of demographics, and provides a rigorous but accessible synopsis of the brain’s general functioning. The book is a combination of highly technical research and anecdotal accounts, as the author interviews many sufferers of depression, endowing the work with a sensitively handled human element. There are times when a lay reader may feel overwhelmed by the large amount of minute detail. However, Zabel never strays too far from the big picture and resists the allure of facile answers: “At my core, I am reductionist—I want to find the simple solution, the fundamental biological problem that is depression...but depression doesn’t support that. It is hugely complex; an emergent outcome of a brain under attack.”
A meticulous and thoughtful scientific exploration.Pub Date: Feb. 1, 2021
ISBN: 978-1-73584-540-1
Page Count: 432
Publisher: Sarah Zabel Enterprises, LLC
Review Posted Online: March 17, 2021
Review Program: Kirkus Indie
A virtuoso performance and an ode to an undervalued medium created by two talented artists.
The veteran actor, comedian, and banjo player teams up with the acclaimed illustrator to create a unique book of cartoons that communicates their personalities.
Martin, also a prolific author, has always been intrigued by the cartoons strewn throughout the pages of the New Yorker. So when he was presented with the opportunity to work with Bliss, who has been a staff cartoonist at the magazine since 1997, he seized the moment. “The idea of a one-panel image with or without a caption mystified me,” he writes. “I felt like, yeah, sometimes I’m funny, but there are these other weird freaks who are actually funny.” Once the duo agreed to work together, they established their creative process, which consisted of working forward and backward: “Forwards was me conceiving of several cartoon images and captions, and Harry would select his favorites; backwards was Harry sending me sketched or fully drawn cartoons for dialogue or banners.” Sometimes, he writes, “the perfect joke occurs two seconds before deadline.” There are several cartoons depicting this method, including a humorous multipanel piece highlighting their first meeting called “They Meet,” in which Martin thinks to himself, “He’ll never be able to translate my delicate and finely honed droll notions.” In the next panel, Bliss thinks, “I’m sure he won’t understand that the comic art form is way more subtle than his blunt-force humor.” The team collaborated for a year and created 150 cartoons featuring an array of topics, “from dogs and cats to outer space and art museums.” A witty creation of a bovine family sitting down to a gourmet meal and one of Dumbo getting his comeuppance highlight the duo’s comedic talent. What also makes this project successful is the team’s keen understanding of human behavior as viewed through their unconventional comedic minds.
A virtuoso performance and an ode to an undervalued medium created by two talented artists.Pub Date: Nov. 17, 2020
ISBN: 978-1-250-26289-9
Page Count: 272
Publisher: Celadon Books
Review Posted Online: Aug. 30, 2020
Kirkus Reviews Issue: Sept. 15, 2020
PERSPECTIVES
A frank and funny but uneven essay collection about neurodiversity.
An experimental, illustrated essay collection that questions neurotypical definitions of what is normal.
From a young age, writer and comedian Myers has been different. In addition to coping with obsessive compulsive disorder and panic attacks, she struggled to read basic social cues. During a round of seven minutes in heaven—a game in which two players spend seven minutes in a closet and are expected to kiss—Myers misread the romantic advances of her best friend and longtime crush, Marley. In Paris, she accidentally invited a sex worker to join her friends for “board games and beer,” thinking he was simply a random stranger who happened to be hitting on her. In community college, a stranger’s request for a pen spiraled her into a panic attack but resulted in a tentative friendship. When the author moved to Australia, she began taking notes on her colleagues in an effort to know them better. As the author says to her co-worker, Tabitha, “there are unspoken social contracts within a workplace that—by some miracle—everyone else already understands, and I don’t….When things Go Without Saying, they Never Get Said, and sometimes people need you to Say Those Things So They Understand What The Hell Is Going On.” At its best, Myers’ prose is vulnerable and humorous, capturing characterization in small but consequential life moments, and her illustrations beautifully complement the text. Unfortunately, the author’s tendency toward unnecessary capitalization and experimental forms is often unsuccessful, breaking the book’s otherwise steady rhythm.
A frank and funny but uneven essay collection about neurodiversity.Pub Date: Oct. 28, 2025
ISBN: 9780063381308
Page Count: 272
Publisher: Morrow/HarperCollins
Review Posted Online: Sept. 12, 2025
Kirkus Reviews Issue: Oct. 15, 2025
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