Readers may occasionally seek less of Moalem’s enthusiasm and ego, but he has a lot of solid information to convey and a...
A compendium of facts and case studies on genes.
Moalem (How Sex Works: Why We Look, Smell, Taste, Feel, and Act the Way We Do, 2009, etc.) examines two main ideas: 1) that your genes are not your destiny—environment and behavior can tune genes up or down or turn other genes on or off in the process of “epigenetic” control; 2) that nobody is “average.” We are all unique in our DNA and how our lives interact with that endowment, so beware of “average daily requirements” and other recommendations. Moalem illustrates these tenets with intriguing stories—e.g., a chef who switched from his meat-heavy, high-fat diet to emphasize fruits and vegetables only to discover that he felt lousy due to the fact that he suffered from hereditary fructose intolerance. Sadly the author relates the story of a little girl given codeine for pain following a tonsillectomy. She had an extra gene coding for the enzyme metabolizing the drug, which resulted in rapid production of excess morphine, which killed her. Moalem describes studies of stress in infant mice (leading them to “give up” when faced with adverse conditions as adults), dietary influences on bee larvae (those given royal jelly become queens; the others, workers) and bullying (one study shows blunted cortisol responses in adulthood). Moalem argues for the usefulness of knowing your genome but is also concerned that the information could be hacked and used against you. He recommends getting detailed medical histories from relatives and explains how even examining your face can be informative about your genetic history. The author covers a wide range of subjects: rare diseases, what’s bad about vitamins and supplements, drugs used in athletic doping, his case of altitude sickness and more.
Readers may occasionally seek less of Moalem’s enthusiasm and ego, but he has a lot of solid information to convey and a stylish way of telling it.Pub Date: April 15, 2014
ISBN: 978-1-4555-4944-3
Page Count: 272
Publisher: Grand Central Publishing
Review Posted Online: March 11, 2014
Kirkus Reviews Issue: April 1, 2014
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular...
A neurosurgeon with a passion for literature tragically finds his perfect subject after his diagnosis of terminal lung cancer.
Writing isn’t brain surgery, but it’s rare when someone adept at the latter is also so accomplished at the former. Searching for meaning and purpose in his life, Kalanithi pursued a doctorate in literature and had felt certain that he wouldn’t enter the field of medicine, in which his father and other members of his family excelled. “But I couldn’t let go of the question,” he writes, after realizing that his goals “didn’t quite fit in an English department.” “Where did biology, morality, literature and philosophy intersect?” So he decided to set aside his doctoral dissertation and belatedly prepare for medical school, which “would allow me a chance to find answers that are not in books, to find a different sort of sublime, to forge relationships with the suffering, and to keep following the question of what makes human life meaningful, even in the face of death and decay.” The author’s empathy undoubtedly made him an exceptional doctor, and the precision of his prose—as well as the moral purpose underscoring it—suggests that he could have written a good book on any subject he chose. Part of what makes this book so essential is the fact that it was written under a death sentence following the diagnosis that upended his life, just as he was preparing to end his residency and attract offers at the top of his profession. Kalanithi learned he might have 10 years to live or perhaps five. Should he return to neurosurgery (he could and did), or should he write (he also did)? Should he and his wife have a baby? They did, eight months before he died, which was less than two years after the original diagnosis. “The fact of death is unsettling,” he understates. “Yet there is no other way to live.”
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular clarity.Pub Date: Jan. 19, 2016
ISBN: 978-0-8129-8840-6
Page Count: 248
Publisher: Random House
Review Posted Online: Sept. 29, 2015
Kirkus Reviews Issue: Oct. 15, 2015
PERSPECTIVES
Occasionally wonky but overall a good case for how the dismal science can make the world less—well, dismal.
“Quality of life means more than just consumption”: Two MIT economists urge that a smarter, more politically aware economics be brought to bear on social issues.
It’s no secret, write Banerjee and Duflo (co-authors: Poor Economics: A Radical Rethinking of the Way To Fight Global Poverty, 2011), that “we seem to have fallen on hard times.” Immigration, trade, inequality, and taxation problems present themselves daily, and they seem to be intractable. Economics can be put to use in figuring out these big-issue questions. Data can be adduced, for example, to answer the question of whether immigration tends to suppress wages. The answer: “There is no evidence low-skilled migration to rich countries drives wage and employment down for the natives.” In fact, it opens up opportunities for those natives by freeing them to look for better work. The problem becomes thornier when it comes to the matter of free trade; as the authors observe, “left-behind people live in left-behind places,” which explains why regional poverty descended on Appalachia when so many manufacturing jobs left for China in the age of globalism, leaving behind not just left-behind people but also people ripe for exploitation by nationalist politicians. The authors add, interestingly, that the same thing occurred in parts of Germany, Spain, and Norway that fell victim to the “China shock.” In what they call a “slightly technical aside,” they build a case for addressing trade issues not with trade wars but with consumption taxes: “It makes no sense to ask agricultural workers to lose their jobs just so steelworkers can keep theirs, which is what tariffs accomplish.” Policymakers might want to consider such counsel, especially when it is coupled with the observation that free trade benefits workers in poor countries but punishes workers in rich ones.
Occasionally wonky but overall a good case for how the dismal science can make the world less—well, dismal.Pub Date: Nov. 12, 2019
ISBN: 978-1-61039-950-0
Page Count: 432
Publisher: PublicAffairs
Review Posted Online: Aug. 28, 2019
Kirkus Reviews Issue: Sept. 15, 2019
SEEN & HEARD
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