A capably guided tour of a scientific wave of the future.
An enthusiastic account of organisms that silently rule the Earth.
Viruses are “smaller than the wavelength of light,” and they replicate by invading a cell, multiplying, and then leaving, often killing the cell. A minuscule fraction cause human disease—polio, measles, flu, Covid-19, some cancers—but most are benign and often an essential part of life. Human viruses receive plenty of attention, but science journalist Ireland hits pay dirt by focusing on those that attack bacteria. Called bacteriophages or “phages,” they often attack deadly human infections. In 1917, scientists discovered that certain liquids, filtered to remove bacteria, destroyed bacterial cultures. They theorized that the fluid contained viruses that were “too small to see with a light microscope.” Researchers took up the idea of using these liquids to treat human infections. “For a few decades in the early twentieth century,” writes the author, “the world went mad for phages, and phage therapy was everywhere.” But phages are tricky. Some are weakly infectious; others are “hyper-specific, targeting only particular strains.” At the time, technology was primitive, and governments were lax about preclinical testing. By the 1930s, antibiotics appeared, miraculous drugs that made infections vanish. Sadly, by the 1990s, their vast overuse in medicine and agriculture was producing a deadly epidemic of increasingly resistant and even entirely impervious bacteria. Inevitably, this revived interest in phages. Both optimistic and realistic, Ireland writes that designing a phage for a specific bacterial strain is more complex than developing an antibiotic, and clinical trials have proven frustrating and expensive. He describes dramatic cures but no breakthroughs so far. At the halfway point of the book, the author rewinds the clock to the 1930s, describing genetic and DNA–related phage research that has led to numerous Nobel Prizes and an ongoing scientific revolution that has extended from the discovery of the double helix to genetic engineering, cloning, and insights into the nature of life itself.
A capably guided tour of a scientific wave of the future.Pub Date: Aug. 15, 2023
ISBN: 9781324050834
Page Count: 304
Publisher: Norton
Review Posted Online: May 9, 2023
Kirkus Reviews Issue: June 1, 2023
The lessons to draw are obvious: Smoke more dope, eat less meat. Like-minded readers will dig it.
The chef, rapper, and TV host serves up a blustery memoir with lashings of self-help.
“I’ve always had a sick confidence,” writes Bronson, ne Ariyan Arslani. The confidence, he adds, comes from numerous sources: being a New Yorker, and more specifically a New Yorker from Queens; being “short and fucking husky” and still game for a standoff on the basketball court; having strength, stamina, and seemingly no fear. All these things serve him well in the rough-and-tumble youth he describes, all stickball and steroids. Yet another confidence-builder: In the big city, you’ve got to sink or swim. “No one is just accepted—you have to fucking show that you’re able to roll,” he writes. In a narrative steeped in language that would make Lenny Bruce blush, Bronson recounts his sentimental education, schooled by immigrant Italian and Albanian family members and the mean streets, building habits good and bad. The virtue of those habits will depend on your take on modern mores. Bronson writes, for example, of “getting my dick pierced” down in the West Village, then grabbing a pizza and smoking weed. “I always smoke weed freely, always have and always will,” he writes. “I’ll just light a blunt anywhere.” Though he’s gone through the classic experiences of the latter-day stoner, flunking out and getting arrested numerous times, Bronson is a hard charger who’s not afraid to face nearly any challenge—especially, given his physique and genes, the necessity of losing weight: “If you’re husky, you’re always dieting in your mind,” he writes. Though vulgar and boastful, Bronson serves up a model that has plenty of good points, including his growing interest in nature, creativity, and the desire to “leave a legacy for everybody.”
The lessons to draw are obvious: Smoke more dope, eat less meat. Like-minded readers will dig it.Pub Date: April 20, 2021
ISBN: 978-1-4197-4478-5
Page Count: 184
Publisher: Abrams
Review Posted Online: May 5, 2021
Kirkus Reviews Issue: June 1, 2021
Alternately admiring and critical, unvarnished, and a closely detailed account of a troubled innovator.
A warts-and-all portrait of the famed techno-entrepreneur—and the warts are nearly beyond counting.
To call Elon Musk (b. 1971) “mercurial” is to undervalue the term; to call him a genius is incorrect. Instead, Musk has a gift for leveraging the genius of others in order to make things work. When they don’t, writes eminent biographer Isaacson, it’s because the notoriously headstrong Musk is so sure of himself that he charges ahead against the advice of others: “He does not like to share power.” In this sharp-edged biography, the author likens Musk to an earlier biographical subject, Steve Jobs. Given Musk’s recent political turn, born of the me-first libertarianism of the very rich, however, Henry Ford also comes to mind. What emerges clearly is that Musk, who may or may not have Asperger’s syndrome (“Empathy did not come naturally”), has nurtured several obsessions for years, apart from a passion for the letter X as both a brand and personal name. He firmly believes that “all requirements should be treated as recommendations”; that it is his destiny to make humankind a multi-planetary civilization through innovations in space travel; that government is generally an impediment and that “the thought police are gaining power”; and that “a maniacal sense of urgency” should guide his businesses. That need for speed has led to undeniable successes in beating schedules and competitors, but it has also wrought disaster: One of the most telling anecdotes in the book concerns Musk’s “demon mode” order to relocate thousands of Twitter servers from Sacramento to Portland at breakneck speed, which trashed big parts of the system for months. To judge by Isaacson’s account, that may have been by design, for Musk’s idea of creative destruction seems to mean mostly chaos.
Alternately admiring and critical, unvarnished, and a closely detailed account of a troubled innovator.Pub Date: Sept. 12, 2023
ISBN: 9781982181284
Page Count: 688
Publisher: Simon & Schuster
Review Posted Online: Sept. 12, 2023
Kirkus Reviews Issue: Oct. 15, 2023
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