Despite the irritating lapses into docudrama, a substantive examination of an important issue.
Heated account of pharmaceutical giant GlaxoSmithKline’s troubles when the company was discovered concealing evidence that suicidal thoughts occurred as a rare side effect of its popular antidepressant Paxil.
Boston Globe science journalist Bass begins her account with the horrifying saga of a painfully shy teenager whose Paxil prescription prompted sleeplessness, agitation, episodes of self-cutting and a suicide attempt. Introduced in the 1980s and ’90s, new psychoactive drugs like Paxil, Prozac and Zoloft helped many depressed patients, the author emphasizes, but reports of troubling side effects were not welcomed by the manufacturers of these wildly profitable medications. Displaying an unfortunate fondness for invented dialogue and passionate internal monologues by leading characters, Bass introduces her heroes and villains. Dressed in white: an idealistic lawyer in the New York State Attorney General’s office, which filed suit against GlaxoSmithKline in 2004; a struggling hospital official who learned that a powerful researcher was collecting money for nonexistent studies; and a brilliant psychiatrist who found suicidal ideation among patients taking Prozac, only to have his findings dismissed by the FDA. Dressed in black: pharmaceutical company scientists and lawyers, as well as psychiatrists whose income from the companies clearly influenced their prescribing habits and their eagerness to interpret questionable research results as favorable to a drug. Bass has little good to say about the FDA, starved of funds by Congress but encouraged to charge “user fees” to speed up new drug approval. Providing more than half the FDA’s drug-review budget, these fees inevitably distorted the approval process. Rather than go to trial, GlaxoSmithKline settled, agreeing to post descriptions of all studies (not just those with positive results) on the Internet. Other companies agreed to do the same, and leading medical journals unanimously adopted guidelines requiring full disclosure in submitted research papers. Congress declined to provide the FDA more money, yet allowed it to raise user’s fees, thereby perpetuating a corrupt process.
Despite the irritating lapses into docudrama, a substantive examination of an important issue.Pub Date: June 17, 2008
ISBN: 978-1-56512-553-7
Page Count: 240
Publisher: Algonquin
Review Posted Online: June 24, 2010
Kirkus Reviews Issue: April 15, 2008
These are not hard and fast rules, but Meyer delivers important reading for those engaged in international business.
A helpful guide to working effectively with people from other cultures.
“The sad truth is that the vast majority of managers who conduct business internationally have little understanding about how culture is impacting their work,” writes Meyer, a professor at INSEAD, an international business school. Yet they face a wider array of work styles than ever before in dealing with clients, suppliers and colleagues from around the world. When is it best to speak or stay quiet? What is the role of the leader in the room? When working with foreign business people, failing to take cultural differences into account can lead to frustration, misunderstanding or worse. Based on research and her experiences teaching cross-cultural behaviors to executive students, the author examines a handful of key areas. Among others, they include communicating (Anglo-Saxons are explicit; Asians communicate implicitly, requiring listeners to read between the lines), developing a sense of trust (Brazilians do it over long lunches), and decision-making (Germans rely on consensus, Americans on one decider). In each area, the author provides a “culture map scale” that positions behaviors in more than 20 countries along a continuum, allowing readers to anticipate the preferences of individuals from a particular country: Do they like direct or indirect negative feedback? Are they rigid or flexible regarding deadlines? Do they favor verbal or written commitments? And so on. Meyer discusses managers who have faced perplexing situations, such as knowledgeable team members who fail to speak up in meetings or Indians who offer a puzzling half-shake, half-nod of the head. Cultural differences—not personality quirks—are the motivating factors behind many behavioral styles. Depending on our cultures, we understand the world in a particular way, find certain arguments persuasive or lacking merit, and consider some ways of making decisions or measuring time natural and others quite strange.
These are not hard and fast rules, but Meyer delivers important reading for those engaged in international business.Pub Date: May 27, 2014
ISBN: 978-1-61039-250-1
Page Count: 288
Publisher: PublicAffairs
Review Posted Online: April 15, 2014
Kirkus Reviews Issue: May 1, 2014
If the authors are serious, this is a silly, distasteful book. If they are not, it’s a brilliant satire.
The authors have created a sort of anti-Book of Virtues in this encyclopedic compendium of the ways and means of power.
Everyone wants power and everyone is in a constant duplicitous game to gain more power at the expense of others, according to Greene, a screenwriter and former editor at Esquire (Elffers, a book packager, designed the volume, with its attractive marginalia). We live today as courtiers once did in royal courts: we must appear civil while attempting to crush all those around us. This power game can be played well or poorly, and in these 48 laws culled from the history and wisdom of the world’s greatest power players are the rules that must be followed to win. These laws boil down to being as ruthless, selfish, manipulative, and deceitful as possible. Each law, however, gets its own chapter: “Conceal Your Intentions,” “Always Say Less Than Necessary,” “Pose as a Friend, Work as a Spy,” and so on. Each chapter is conveniently broken down into sections on what happened to those who transgressed or observed the particular law, the key elements in this law, and ways to defensively reverse this law when it’s used against you. Quotations in the margins amplify the lesson being taught. While compelling in the way an auto accident might be, the book is simply nonsense. Rules often contradict each other. We are told, for instance, to “be conspicuous at all cost,” then told to “behave like others.” More seriously, Greene never really defines “power,” and he merely asserts, rather than offers evidence for, the Hobbesian world of all against all in which he insists we live. The world may be like this at times, but often it isn’t. To ask why this is so would be a far more useful project.
If the authors are serious, this is a silly, distasteful book. If they are not, it’s a brilliant satire.Pub Date: Sept. 1, 1998
ISBN: 0-670-88146-5
Page Count: 430
Publisher: Viking
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: July 15, 1998
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