Highly informative and accessible for general readers.
Biopharmaceutical consultant Kirsch debuts with a popular account of the search for new drugs, from prehistory through the rise of big pharma.
This lucid, anecdote-rich book, co-authored by science writer Ogas (co-author: Shrinks: The Untold Story of Psychiatry, 2015, etc.), covers familiar ground for specialists but offers a bright overview for the rest of us of humankind’s hunt for medicines, first in the molecules of plants, then in synthetic compounds, and now in the human genome. Throughout history, drug discoveries have been “entirely fortuitous,” writes the author, who has been a chief science officer with several major drug firms. Successful drug hunting takes “talent, moxie, persistence, luck—and even then, it might not be enough.” In fact, most researchers “never” find new compounds that safely and effectively improve health. That said, Kirsch tells the fascinating stories of historic drug discoveries over the centuries, from opium (used in 3400 B.C.E.) to chloroform, ether, quinine, aspirin, penicillin, insulin, the birth control pill, and psychoactive medicines. Once physician-botanists (until the Renaissance) and now physician–molecular biologists, drug researchers have always faced “dismayingly difficult” trial-and-error screening. Recounting the work of researchers from Valerius Cordus (b. 1515), who wrote a landmark apothecary manual, to Paul Ehrlich, who developed the cure for syphilis, to Gregory Pincus, a scandal-tainted scientist who worked with two elderly feminists to develop an effective oral contraception drug, Kirsch describes the emergence of the science of pharmacology by the mid-20th century. Today, 50 to 70 percent of all clinical drug trials fail, and each FDA–approved drug requires an average investment of $1.5 billion and 14 years of research. Kirsch notes that big pharma has little incentive to develop medicines that produce cures—as opposed to drugs for chronic diseases like diabetes and high cholesterol, which users purchase again and again—and faults drug makers’ hostility to the “risk-laden reality of modern drug-hunting.”
Highly informative and accessible for general readers.Pub Date: Jan. 3, 2017
ISBN: 978-1-62872-718-0
Page Count: 312
Publisher: Arcade
Review Posted Online: Oct. 19, 2016
Kirkus Reviews Issue: Nov. 1, 2016
An intriguing collection of essays covering much familiar ground, but with enough new insights and fresh perspectives to interest both Civil War buffs and casual readers. Boritt (Civil War Studies/Gettysburg College; Why the Confederacy Lost, 1992) assembles five essays by top specialists in the field, exploring the relationship of wartime Commander-in-Chief Lincoln to his leaders on the battlefield. The common denominator in those relations, the volume argues, was conflict, in part because of the inherent tension between civil and military authorities but also due to the personalities of Lincoln and those he chose to command. Stephen Sears (George B. McClellan, 1988) again examines ``little Mac,'' a supremely cautious man who never thought he had enough men or matÇriel to fight the Confederates; Lincoln removed him from command after he failed to exploit the narrow Union victory at Antietam. Mark Neely (The Last Best Hope of Earth, 1993) assays ``Fighting Joe'' Hooker, who led Union forces into a blundering defeat on bad terrain at Chancellorsville. Boritt looks at George Meade and the Battle of Gettysburg; like McClellan, Meade was cautious and slow, a trait that infuriated Lincoln and led him briefly to consider leaving Washington to take command of the Army himself. Michael Fellman (History/Simon Fraser Univ., British Columbia) writes about William Tecumseh Sherman, with whom Lincoln had distant and infrequent contact. Lincoln counseled Sherman to show mercy to Southerners—advice the general ignored, but his March to the Sea helped clinch Lincoln's re-election, which for a time seemed doubtful. Finally, John Y. Simon (History/Univ. of Southern Illinois) discusses Ulysses S. Grant, the general with whom it is often assumed Lincoln had the best relationship: The volume makes it clear that was true only in comparison with the president's other fractured ties. Five thoughtful and well-written essays, further grist for the mill of seemingly endless fascination with America's costliest war.
Pub Date: Oct. 1, 1994
ISBN: 0-19-508505-1
Page Count: 256
Publisher: Oxford Univ.
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Aug. 1, 1994
BOOK REVIEW
BOOK REVIEW
The fundamentals of Einstein's theory of special relativity, presented in the form of a series of imaginary dialogues among scientists of three different eras. Fritzsch (Max Planck Institute for Physics, Munich; Quarks: The Stuff of Matter, 1983) begins by sending a fictitious modern physicist, Adrian Haller, to England, where he meets Sir Isaac Newton, who has been returned to Earth. Newton is curious about developments in physics since his day, and the two men spend several chapters discussing Newton's concepts of space, time, and light. When the conversation arrives at the subject of Albert Einstein's contributions to science, Newton persuades Haller to take him for a visit to Bern, Switzerland, where they meet the father of relativity. The three physicists then engage in a series of dialogues on how Einstein modified Newton's ideas of the universe, and on how modern science has both verified and extended Einstein's own theories. While there is an unavoidable kernel of mathematics in any discussion of physical concepts, the derivation of Einstein's famous equation, E = mc2, should be within the grasp of anyone who passed high school algebra. The key ideas are presented clearly, and the discussion touches on such subjects as the source of the sun's energy, the future of nuclear and fusion power, antimatter, and the decay of the proton. Fritzsch's handling of the dialogues and of the flimsy narrative framework does not suggest that he should take up fiction as a career. But the ideas come across clearly, even entertainingly, in spite of what appears to be a rather pedestrian translation. Occasionally stiff, but always readable; a good introduction to modern physics for any reader willing to invest a little thought in the subject. (45 halftones, 41 line drawings, 1 table)
Pub Date: Oct. 15, 1994
ISBN: 0-226-26557-9
Page Count: 336
Publisher: Univ. of Chicago
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Aug. 1, 1994
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