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THE MYSTERIOUS WORLD OF THE HUMAN GENOME

An enlightening account of past and present knowledge and the future possibilities of human heredity.

The information revolution in silicon gets the headlines, but a revolution in genetics has been running in parallel and will soon affect our lives even more profoundly. Plenty of authors are paying attention, but British physician and researcher Ryan (Metamorphosis: Unmasking the Mystery of How Life Transforms, 2011, etc.) delivers an up-to-date history that will be definitive—at least for a few years.

After a passing glance at Gregor Mendel and Charles Darwin, Ryan explores the work of one of the greatest scientists to never have won a Nobel Prize: Oswald Avery, who led the team that discovered, in the 1940s, that DNA carries genetic information. Until that point, everyone assumed that genes were proteins—extremely complex molecules. However, despite an impressive size, DNA has a simple, repetitious structure. In an act of dazzling creativity (others did the actual research), James Watson and Francis Crick determined the makeup of DNA in 1952. Researchers soon deciphered its code, and the race was on to learn how genes make a living thing. Matters have become complicated in recent years, but we’re getting close. Ryan quotes liberally from The Eighth Day of Creation (1979), Horace Freeland Judson’s masterpiece on the early decades of DNA research. Like Judson, Ryan conducts thoughtful interviews, describes experiments in precise detail, and takes care to include the inevitable politics, personalities, frustrations, and controversies. He manages to make sense of a relentless stream of discoveries that have already revolutionized our picture of human evolution and which will allow us—not quite yet but any year now—to create life in the lab and cure disease. “In April 2015 the human embryo was deliberately engineered in a scientific experiment for the first time,” writes the author. “I believe that this is as great a leap as the discovery of gravity by Newton [and] relativity by Einstein.”

An enlightening account of past and present knowledge and the future possibilities of human heredity.

Pub Date: Feb. 16, 2016

ISBN: 978-1633881525

Page Count: 342

Publisher: Prometheus Books

Review Posted Online: Nov. 18, 2015

Kirkus Reviews Issue: Dec. 1, 2015

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SEVEN BRIEF LESSONS ON PHYSICS

An intriguing meditation on the nature of the universe and our attempts to understand it that should appeal to both...

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Italian theoretical physicist Rovelli (General Relativity: The Most Beautiful of Theories, 2015, etc.) shares his thoughts on the broader scientific and philosophical implications of the great revolution that has taken place over the past century.

These seven lessons, which first appeared as articles in the Sunday supplement of the Italian newspaper Sole 24 Ore, are addressed to readers with little knowledge of physics. In less than 100 pages, the author, who teaches physics in both France and the United States, cogently covers the great accomplishments of the past and the open questions still baffling physicists today. In the first lesson, he focuses on Einstein's theory of general relativity. He describes Einstein's recognition that gravity "is not diffused through space [but] is that space itself" as "a stroke of pure genius." In the second lesson, Rovelli deals with the puzzling features of quantum physics that challenge our picture of reality. In the remaining sections, the author introduces the constant fluctuations of atoms, the granular nature of space, and more. "It is hardly surprising that there are more things in heaven and earth, dear reader, than have been dreamed of in our philosophy—or in our physics,” he writes. Rovelli also discusses the issues raised in loop quantum gravity, a theory that he co-developed. These issues lead to his extraordinary claim that the passage of time is not fundamental but rather derived from the granular nature of space. The author suggests that there have been two separate pathways throughout human history: mythology and the accumulation of knowledge through observation. He believes that scientists today share the same curiosity about nature exhibited by early man.

An intriguing meditation on the nature of the universe and our attempts to understand it that should appeal to both scientists and general readers.

Pub Date: March 1, 2016

ISBN: 978-0-399-18441-3

Page Count: 96

Publisher: Riverhead

Review Posted Online: Dec. 7, 2015

Kirkus Reviews Issue: Dec. 15, 2015

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THE ORDER OF TIME

As much a work of philosophy as of physics and full of insights for readers willing to work hard.

Undeterred by a subject difficult to pin down, Italian theoretical physicist Rovelli (Reality Is Not What It Seems: The Journey to Quantum Gravity, 2017, etc.) explains his thoughts on time.

Other scientists have written primers on the concept of time for a general audience, but Rovelli, who also wrote the bestseller Seven Brief Lessons on Physics, adds his personal musings, which are astute and rewarding but do not make for an easy read. “We conventionally think of time,” he writes, “as something simple and fundamental that flows uniformly, independently from everything else, uniformly from the past to the future, measured by clocks and watches. In the course of time, the events of the universe succeed each other in an orderly way: pasts, presents, futures. The past is fixed, the future open….And yet all of this has turned out to be false.” Rovelli returns again and again to the ideas of three legendary men. Aristotle wrote that things change continually. What we call “time” is the measurement of that change. If nothing changed, time would not exist. Newton disagreed. While admitting the existence of a time that measures events, he insisted that there is an absolute “true time” that passes relentlessly. If the universe froze, time would roll on. To laymen, this may seem like common sense, but most philosophers are not convinced. Einstein asserted that both are right. Aristotle correctly explained that time flows in relation to something else. Educated laymen know that clocks register different times when they move or experience gravity. Newton’s absolute exists, but as a special case in Einstein’s curved space-time. According to Rovelli, our notion of time dissolves as our knowledge grows; complex features swell and then retreat and perhaps vanish entirely. Furthermore, equations describing many fundamental physical phenomena don’t require time.

As much a work of philosophy as of physics and full of insights for readers willing to work hard.

Pub Date: May 18, 2018

ISBN: 978-0-7352-1610-5

Page Count: 256

Publisher: Riverhead

Review Posted Online: April 2, 2018

Kirkus Reviews Issue: April 15, 2018

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