A significant work about a horrifying example of widespread pharmaceutical negligence.
A novelistic investigation of the shocking story of thalidomide in the U.S.
In 1962, an article in Life magazine alerted readers to the severe birth defects suffered by babies in Germany and England whose mothers had taken the allegedly safe sleeping pill thalidomide early in their pregnancies. What the piece didn't mention was the fact that the drug was also circulating widely in the U.S. At the time, Cincinnati-based drug company William S. Merrell was not only pressuring the FDA to approve its version of thalidomide; it was also distributing samples of the drug to more than 700 doctors, who passed it on to approximately 20,000 patients as well as to other physicians. Although FDA approval of thalidomide was blocked—largely through the efforts of implacable medical reviewer Frances Kelsey, who, unusually for the time period, “held both an MD and a PhD and had forged a career in the hard sciences while married with children”—little effort was made to retrieve the drug samples that had been distributed to doctors. As a result, dozens of children were born with shortened limbs and a variety of other defects. In a wide-ranging, thoroughly researched, and suspenseful account, novelist Vanderbes creates a compelling cast of heroes and villains: Kelsey and the researchers she enlisted to help her study the drug on one side; and the unscrupulous administrators of the drug companies, both in the U.S. and Germany, where the drug was developed and insufficiently tested in a company run by former members of the Nazi Party, on the other. Interviews with those who were born with damage caused by the drug—some of whom were abandoned by their parents—add another compelling, emotional layer to the text. The author weaves the various strands of her riveting tale together with aplomb, and she clearly explains even the most puzzling aspects of it.
A significant work about a horrifying example of widespread pharmaceutical negligence.Pub Date: June 27, 2023
ISBN: 9780525512264
Page Count: 432
Publisher: Random House
Review Posted Online: May 18, 2023
Kirkus Reviews Issue: June 15, 2023
A powerful reiteration of principles—and some fresh ideas—from the longest-serving independent in congressional history.
Another chapter in a long fight against inequality.
Building on his Fighting Oligarchy tour, which this year drew 280,000 people to rallies in red and blue states, Sanders amplifies his enduring campaign for economic fairness. The Vermont senator offers well-timed advice for combating corruption and issues a robust plea for national soul-searching. His argument rests on alarming data on the widening wealth gap’s impact on democracy. Bolstered by a 2010 Supreme Court decision that removed campaign finance limits, “100 billionaire families spent $2.6 billion” on 2024 elections. Sanders focuses on the Trump administration and congressional Republicans, describing their enactment of the “Big Beautiful Bill,” with its $1 trillion in tax breaks for the richest Americans and big social safety net cuts, as the “largest transfer of wealth” in living memory. But as is his custom, he spreads the blame, dinging Democrats for courting wealthy donors while ignoring the “needs and suffering” of the working class. “Trump filled the political vacuum that the Democrats created,” he writes, a resonant diagnosis. Urging readers not to surrender to despair, Sanders offers numerous legislative proposals. These would empower labor unions, cut the workweek to 32 hours, regulate campaign spending, reduce gerrymandering, and automatically register 18-year-olds to vote. Grassroots supporters can help by running for local office, volunteering with a campaign, and asking educators how to help support public schools. Meanwhile, Sanders asks us “to question the fundamental moral values that underlie” a system that enables “the top 1 percent” to “own more wealth than the bottom 93 percent.” Though his prose sometimes reads like a transcribed speech with built-in applause lines, Sanders’ ideas are specific, clear, and commonsensical. And because it echoes previous statements, his call for collective introspection lands as genuine.
A powerful reiteration of principles—and some fresh ideas—from the longest-serving independent in congressional history.Pub Date: Oct. 21, 2025
ISBN: 9798217089161
Page Count: 160
Publisher: Crown
Review Posted Online: Oct. 21, 2025
Kirkus Reviews Issue: Dec. 15, 2025
BOOK REVIEW
BOOK REVIEW
BOOK REVIEW
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular...
A neurosurgeon with a passion for literature tragically finds his perfect subject after his diagnosis of terminal lung cancer.
Writing isn’t brain surgery, but it’s rare when someone adept at the latter is also so accomplished at the former. Searching for meaning and purpose in his life, Kalanithi pursued a doctorate in literature and had felt certain that he wouldn’t enter the field of medicine, in which his father and other members of his family excelled. “But I couldn’t let go of the question,” he writes, after realizing that his goals “didn’t quite fit in an English department.” “Where did biology, morality, literature and philosophy intersect?” So he decided to set aside his doctoral dissertation and belatedly prepare for medical school, which “would allow me a chance to find answers that are not in books, to find a different sort of sublime, to forge relationships with the suffering, and to keep following the question of what makes human life meaningful, even in the face of death and decay.” The author’s empathy undoubtedly made him an exceptional doctor, and the precision of his prose—as well as the moral purpose underscoring it—suggests that he could have written a good book on any subject he chose. Part of what makes this book so essential is the fact that it was written under a death sentence following the diagnosis that upended his life, just as he was preparing to end his residency and attract offers at the top of his profession. Kalanithi learned he might have 10 years to live or perhaps five. Should he return to neurosurgery (he could and did), or should he write (he also did)? Should he and his wife have a baby? They did, eight months before he died, which was less than two years after the original diagnosis. “The fact of death is unsettling,” he understates. “Yet there is no other way to live.”
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular clarity.Pub Date: Jan. 19, 2016
ISBN: 978-0-8129-8840-6
Page Count: 248
Publisher: Random House
Review Posted Online: Sept. 29, 2015
Kirkus Reviews Issue: Oct. 15, 2015
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