THREE ON THE EDGE

The human side of research medicine is the focus of this account of three patients participating in clinical trials of new drugs for the treatment of AIDS and cancer. In 1995 and 1996 science writer Kelly (co-author with Thomas Verny of The Secret Life of the Unborn Child, not reviewed) spent some 200 hours with Edward Sandisfield, Romy Hochman, and Julie Conte as they faced life-threatening diseases. Sandisfield, a middle-age gay man knowledgeable about AIDS and its treatment, was so desperate to win a place in the clinical trial at Bellevue of a new protease inhibitor, indivir, in combination with AZT and 3TC, that he was prepared to lie his way into the program if necessary. The Hochmans put their 14-year-old daughter with osteosarcoma (a form of bone cancer that frequently metastasizes to the lungs) into a clinical trial at NYU Medical Center to boost her chances of survival; however, Romy was randomized into the control group, receiving only standard treatment. Conte, a 34-year-old woman with breast cancer, was leery of joining a clinical trial testing a high-dose combination-drug therapy, but having already lost her mother and one sister to the disease, she entered the program at Fox Chase Cancer Center in Pennsylvania. Kelly stayed with his three subjects during exams, interviews, and treatment, observing them and talking to them about their experiences, their hopes, and their fears, and interviewing their families, friends, and doctors. Some conversations seem to be reported verbatim, at times giving the stories an up-close and personal feel. In each, Kelly inserts an essay on the disease and the treatment being tested. While the stories end with all three patients alive, an afterword reveals that by 1997 one had succumbed. Kelly’s discussion of the medicine is thorough, but the portraits of his subjects are uneven. Sandisfield’s story is the most complete and his character and his world the best delineated; by comparison, Conte’s story seems sketchy, and the teenager Hochman remains opaque.

Pub Date: Jan. 12, 1999

ISBN: 0-553-10113-7

Page Count: 352

Publisher: Bantam

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: Nov. 15, 1998

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Necessarily swift and adumbrative as well as inclusive, focused, and graceful.

A LITTLE HISTORY OF POETRY

A light-speed tour of (mostly) Western poetry, from the 4,000-year-old Gilgamesh to the work of Australian poet Les Murray, who died in 2019.

In the latest entry in the publisher’s Little Histories series, Carey, an emeritus professor at Oxford whose books include What Good Are the Arts? and The Unexpected Professor: An Oxford Life in Books, offers a quick definition of poetry—“relates to language as music relates to noise. It is language made special”—before diving in to poetry’s vast history. In most chapters, the author deals with only a few writers, but as the narrative progresses, he finds himself forced to deal with far more than a handful. In his chapter on 20th-century political poets, for example, he talks about 14 writers in seven pages. Carey displays a determination to inform us about who the best poets were—and what their best poems were. The word “greatest” appears continually; Chaucer was “the greatest medieval English poet,” and Langston Hughes was “the greatest male poet” of the Harlem Renaissance. For readers who need a refresher—or suggestions for the nightstand—Carey provides the best-known names and the most celebrated poems, including Paradise Lost (about which the author has written extensively), “Kubla Khan,” “Ozymandias,” “The Charge of the Light Brigade,” Wordsworth and Coleridge’s Lyrical Ballads, which “changed the course of English poetry.” Carey explains some poetic technique (Hopkins’ “sprung rhythm”) and pauses occasionally to provide autobiographical tidbits—e.g., John Masefield, who wrote the famous “Sea Fever,” “hated the sea.” We learn, as well, about the sexuality of some poets (Auden was bisexual), and, especially later on, Carey discusses the demons that drove some of them, Robert Lowell and Sylvia Plath among them. Refreshingly, he includes many women in the volume—all the way back to Sappho—and has especially kind words for Marianne Moore and Elizabeth Bishop, who share a chapter.

Necessarily swift and adumbrative as well as inclusive, focused, and graceful.

Pub Date: April 21, 2020

ISBN: 978-0-300-23222-6

Page Count: 304

Publisher: Yale Univ.

Review Posted Online: Feb. 9, 2020

Kirkus Reviews Issue: March 1, 2020

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SLEEPERS

An extraordinary true tale of torment, retribution, and loyalty that's irresistibly readable in spite of its intrusively melodramatic prose. Starting out with calculated, movie-ready anecdotes about his boyhood gang, Carcaterra's memoir takes a hairpin turn into horror and then changes tack once more to relate grippingly what must be one of the most outrageous confidence schemes ever perpetrated. Growing up in New York's Hell's Kitchen in the 1960s, former New York Daily News reporter Carcaterra (A Safe Place, 1993) had three close friends with whom he played stickball, bedeviled nuns, and ran errands for the neighborhood Mob boss. All this is recalled through a dripping mist of nostalgia; the streetcorner banter is as stilted and coy as a late Bowery Boys film. But a third of the way in, the story suddenly takes off: In 1967 the four friends seriously injured a man when they more or less unintentionally rolled a hot-dog cart down the steps of a subway entrance. The boys, aged 11 to 14, were packed off to an upstate New York reformatory so brutal it makes Sing Sing sound like Sunnybrook Farm. The guards continually raped and beat them, at one point tossing all of them into solitary confinement, where rats gnawed at their wounds and the menu consisted of oatmeal soaked in urine. Two of Carcaterra's friends were dehumanized by their year upstate, eventually becoming prominent gangsters. In 1980, they happened upon the former guard who had been their principal torturer and shot him dead. The book's stunning denouement concerns the successful plot devised by the author and his third friend, now a Manhattan assistant DA, to free the two killers and to exact revenge against the remaining ex-guards who had scarred their lives so irrevocably. Carcaterra has run a moral and emotional gauntlet, and the resulting book, despite its flaws, is disturbing and hard to forget. (Film rights to Propaganda; author tour)

Pub Date: July 10, 1995

ISBN: 0-345-39606-5

Page Count: 432

Publisher: Ballantine

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: May 1, 1995

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