A smart, engrossing tale that entertainingly uses science.
A genetic algorithm intended as a cure for cancer becomes part of someone’s nefarious and deadly experiments in this techno-thriller.
After losing both parents to cancer, oncologist Dr. Juan Gutierrez devoted his life to finding a cure. While researching generations of species at the pharmaceutical company AgriMed, Juan uncovers an evolutionary pattern. From this, he derives an algorithm that he hopes will combat cancer. Meanwhile, FBI Special Agent Nate Carrington is investigating cases of lethal attacks by animals, such as dogs and birds. These cases are linked by the animals’ DNA evidence, which suggests some form of genetic manipulation. Nate soon determines that someone has pilfered Juan’s algorithm for experiments that ultimately include human subjects. To make matters worse, the stolen algorithm is an older, less stable version and leads to a number of people becoming infected with a life-threatening virus. One of the stricken may be Juan’s new romantic interest, Kathy O’Reilly, who happens to be a survivor of an animal attack. She and her Nevada rancher parents, Frank and Megan, are unwitting participants in an experiment that puts many in danger. Nate and Juan have little time to find the culprit and a cure before the death count among humans starts rising exponentially. Rothman’s (Perimeter, 2018, etc.) tale moves at a steady clip. Dialogue, in particular, is concise; in one scene, Juan converses with his boss over the phone and police officers in person, and the concurrent exchanges are clear and coherent. Scientific terminology is likewise comprehensible, thanks to the author supplying context or Juan simply explaining terms to an individual. While characters are dynamic, especially the O’Reillys, the most memorable is Jasper, a stray dog Frank and Megan take in. Readers know from the beginning that the hyper-intelligent canine is a lab escapee. But despite Jasper’s tie to the experiments, Rothman zeros in on his empathy and fierce loyalty, traits that make his human counterparts even more likable. In useful addenda, the author elucidates on two subjects from the narrative, genetically modified organisms and gene therapy.
A smart, engrossing tale that entertainingly uses science.Pub Date: Feb. 15, 2019
ISBN: 978-1-79027-123-8
Page Count: 352
Publisher: Time Tunnel Media
Review Posted Online: March 29, 2019
Review Program: Kirkus Indie
The phrase “tour de force” could have been invented for this audacious novel.
Four men who meet as college roommates move to New York and spend the next three decades gaining renown in their professions—as an architect, painter, actor and lawyer—and struggling with demons in their intertwined personal lives.
Yanagihara (The People in the Trees, 2013) takes the still-bold leap of writing about characters who don’t share her background; in addition to being male, JB is African-American, Malcolm has a black father and white mother, Willem is white, and “Jude’s race was undetermined”—deserted at birth, he was raised in a monastery and had an unspeakably traumatic childhood that’s revealed slowly over the course of the book. Two of them are gay, one straight and one bisexual. There isn’t a single significant female character, and for a long novel, there isn’t much plot. There aren’t even many markers of what’s happening in the outside world; Jude moves to a loft in SoHo as a young man, but we don’t see the neighborhood change from gritty artists’ enclave to glitzy tourist destination. What we get instead is an intensely interior look at the friends’ psyches and relationships, and it’s utterly enthralling. The four men think about work and creativity and success and failure; they cook for each other, compete with each other and jostle for each other’s affection. JB bases his entire artistic career on painting portraits of his friends, while Malcolm takes care of them by designing their apartments and houses. When Jude, as an adult, is adopted by his favorite Harvard law professor, his friends join him for Thanksgiving in Cambridge every year. And when Willem becomes a movie star, they all bask in his glow. Eventually, the tone darkens and the story narrows to focus on Jude as the pain of his past cuts deep into his carefully constructed life.
The phrase “tour de force” could have been invented for this audacious novel.Pub Date: March 10, 2015
ISBN: 978-0-385-53925-8
Page Count: 720
Publisher: Doubleday
Review Posted Online: Dec. 21, 2014
Kirkus Reviews Issue: Jan. 1, 2015
BOOK REVIEW
BOOK REVIEW
PROFILES
PERSPECTIVES
Genetically engineered dinosaurs run amok in Crichton's new, vastly entertaining science thriller. From the introduction alone—a classically Crichton-clear discussion of the implications of biotechnological research—it's evident that the Harvard M.D. has bounced back from the science-fantasy silliness of Sphere (1987) for another taut reworking of the Frankenstein theme, as in The Andromeda Strain and The Terminal Man. Here, Dr. Frankenstein is aging billionaire John Hammond, whose monster is a manmade ecosystem based on a Costa Rican island. Designed as the world's ultimate theme park, the ecosystem boasts climate and flora of the Jurassic Age and—most spectacularly—15 varieties of dinosaurs, created by elaborate genetic engineering that Crichton explains in fascinating detail, rich with dino-lore and complete with graphics. Into the park, for a safety check before its opening, comes the novel's band of characters—who, though well drawn, double as symbolic types in this unsubtle morality play. Among them are hero Alan Grant, noble paleontologist; Hammond, venal and obsessed; amoral dino-designer Henry Wu; Hammond's two innocent grandchildren; and mathematician Ian Malcolm, who in long diatribes serves as Crichton's mouthpiece to lament the folly of science. Upon arrival, the visitors tour the park; meanwhile, an industrial spy steals some dino embryos by shutting down the island's power—and its security grid, allowing the beasts to run loose. The bulk of the remaining narrative consists of dinos—ferocious T. Rex's, voracious velociraptors, venom-spitting dilophosaurs—stalking, ripping, and eating the cast in fast, furious, and suspenseful set-pieces as the ecosystem spins apart. And can Grant prevent the dinos from escaping to the mainland to create unchecked havoc? Though intrusive, the moralizing rarely slows this tornado-paced tale, a slick package of info-thrills that's Crichton's most clever since Congo (1980)—and easily the most exciting dinosaur novel ever written. A sure-fire best-seller.
Pub Date: Nov. 7, 1990
ISBN: 0394588169
Page Count: 424
Publisher: Knopf
Review Posted Online: Sept. 21, 2011
Kirkus Reviews Issue: Oct. 15, 1990
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