An interesting tale of how personal ambition, scientific curiosity, and the pursuit of wealth led to life-extending drugs.
The story of two small biotech firms who vied to dominate the market for a cancer drug and reaped billions of dollars in compensation.
During the “great biotechnology decade of the 2010s,” Pharmacyclics and Acerta, both based in California, worked feverishly to develop a new drug that used BTK inhibitors to treat chronic lymphocytic leukemia with minimal side effects. Vardi, managing editor at MarketWatch and former senior editor at Forbes, tells a fascinating story of the science behind this approach and the financial arrangements, medical controversies, regulatory processes, and business rivalries without which the two competing drugs—Imbruvica and Calquence—would not have become publicly available. Driving the quest was the possibility of huge sales; in 2020, Imbruvica had $6.6 billion in revenues. Such sales would enable the companies to be sold to bigger biotech companies, with massive payouts to investors and management. The major investor in Pharmacyclics, for example, made $3.5 billion on his $50 million investment. Vardi brings readers on to significant phone calls, places them at management meetings, and reveals in detail the deliberations that occurred among investors, medical officers, hospital doctors, and federal regulators. We learn the backstories of the key participants and the science and politics behind experimental drug trials, the competition among venture capitalists and hedge fund managers, and the strategic calculations of big pharma (Johnson & Johnson, AstraZeneca) as it engaged the “small biotech companies with experimental therapies” then dominating research and development. Tens of thousands of patients eventually benefitted, although the financial burden—a blood cancer drug can cost $10,000 per month and has to be taken for the duration of the patient’s life—is staggering. The book will appeal to readers of Brendan Borrell’s The First Shot and Gregory Zuckerman’s A Shot To Save the World.
An interesting tale of how personal ambition, scientific curiosity, and the pursuit of wealth led to life-extending drugs.Pub Date: Jan. 10, 2023
ISBN: 978-0-393-54095-6
Page Count: 288
Publisher: Norton
Review Posted Online: Oct. 10, 2022
Kirkus Reviews Issue: Nov. 1, 2022
A clearly delineated guide to finally eradicate poverty in America.
A thoughtful program for eradicating poverty from the Pulitzer Prize–winning author of Evicted.
“America’s poverty is not for lack of resources,” writes Desmond. “We lack something else.” That something else is compassion, in part, but it’s also the lack of a social system that insists that everyone pull their weight—and that includes the corporations and wealthy individuals who, the IRS estimates, get away without paying upward of $1 trillion per year. Desmond, who grew up in modest circumstances and suffered poverty in young adulthood, points to the deleterious effects of being poor—among countless others, the precarity of health care and housing (with no meaningful controls on rent), lack of transportation, the constant threat of losing one’s job due to illness, and the need to care for dependent children. It does not help, Desmond adds, that so few working people are represented by unions or that Black Americans, even those who have followed the “three rules” (graduate from high school, get a full-time job, wait until marriage to have children), are far likelier to be poor than their White compatriots. Furthermore, so many full-time jobs are being recast as contracted, fire-at-will gigs, “not a break from the norm as much as an extension of it, a continuation of corporations finding new ways to limit their obligations to workers.” By Desmond’s reckoning, besides amending these conditions, it would not take a miracle to eliminate poverty: about $177 billion, which would help end hunger and homelessness and “make immense headway in driving down the many agonizing correlates of poverty, like violence, sickness, and despair.” These are matters requiring systemic reform, which will in turn require Americans to elect officials who will enact that reform. And all of us, the author urges, must become “poverty abolitionists…refusing to live as unwitting enemies of the poor.” Fortune 500 CEOs won’t like Desmond’s message for rewriting the social contract—which is precisely the point.
A clearly delineated guide to finally eradicate poverty in America.Pub Date: March 21, 2023
ISBN: 9780593239919
Page Count: 288
Publisher: Crown
Review Posted Online: Nov. 30, 2022
Kirkus Reviews Issue: Jan. 1, 2023
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PERSPECTIVES
PERSPECTIVES
SEEN & HEARD
Alternately admiring and critical, unvarnished, and a closely detailed account of a troubled innovator.
A warts-and-all portrait of the famed techno-entrepreneur—and the warts are nearly beyond counting.
To call Elon Musk (b. 1971) “mercurial” is to undervalue the term; to call him a genius is incorrect. Instead, Musk has a gift for leveraging the genius of others in order to make things work. When they don’t, writes eminent biographer Isaacson, it’s because the notoriously headstrong Musk is so sure of himself that he charges ahead against the advice of others: “He does not like to share power.” In this sharp-edged biography, the author likens Musk to an earlier biographical subject, Steve Jobs. Given Musk’s recent political turn, born of the me-first libertarianism of the very rich, however, Henry Ford also comes to mind. What emerges clearly is that Musk, who may or may not have Asperger’s syndrome (“Empathy did not come naturally”), has nurtured several obsessions for years, apart from a passion for the letter X as both a brand and personal name. He firmly believes that “all requirements should be treated as recommendations”; that it is his destiny to make humankind a multi-planetary civilization through innovations in space travel; that government is generally an impediment and that “the thought police are gaining power”; and that “a maniacal sense of urgency” should guide his businesses. That need for speed has led to undeniable successes in beating schedules and competitors, but it has also wrought disaster: One of the most telling anecdotes in the book concerns Musk’s “demon mode” order to relocate thousands of Twitter servers from Sacramento to Portland at breakneck speed, which trashed big parts of the system for months. To judge by Isaacson’s account, that may have been by design, for Musk’s idea of creative destruction seems to mean mostly chaos.
Alternately admiring and critical, unvarnished, and a closely detailed account of a troubled innovator.Pub Date: Sept. 12, 2023
ISBN: 9781982181284
Page Count: 688
Publisher: Simon & Schuster
Review Posted Online: Sept. 12, 2023
Kirkus Reviews Issue: Oct. 15, 2023
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