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RAETHER'S ENZYME

A plausibly chilling what-if tale with a smart, sensitive hero.

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A young woman whose body contains a cancer-curing enzyme becomes the target of a ruthless conspiracy in this debut thriller.

Last year, Megan Bishop’s mother died of cancer and her distraught father killed himself. Megan left Seattle for her parents’ isolated cabin in Stillanomish Valley, where she tries to work on her master’s degree coding project—but her peace is interrupted by an avalanche of strangers begging for help. Doxxers have invaded confidential medical records to publicly identify those belonging to a rare group of people whose livers contain a biomaterial that prevents and cures cancer called Carcinoma Immune Factor 117—or Raether’s enzyme, after a study subject. Megan is one, and the gold rush for her biomaterial soon goes beyond cancer patients. Some R-positives like Megan have disappeared, perhaps kidnapped by cartels, and now violent criminals are after her at the behest of a wealthy, power-seeking, and malignantly bitter man. Their first attempt fails, and Megan goes into hiding with the help of her Seattle friends, but the bounty hunters are well funded and determined to get their payoff. Megan soon faces an ordeal that will test her intelligence, problem-solving skills, and courage to the utmost. In his book, Flynn goes to some very dark places with his intriguing scenario. Innocents die; authority figures offer dubious protection; and Megan gets caught in a hideous nightmare. Some R-positives are turned into lobotomized organ donors. The author nicely captures the atmosphere in Megan’s circle of brainy, nerdy, sweet friends, making good use of the hero’s admirably analytical mind in the final showdown. The pace lags in the middle section as the specifics of Megan’s flight and identity change are worked out in careful detail, but the ending is taut and rivetingly suspenseful.

A plausibly chilling what-if tale with a smart, sensitive hero.

Pub Date: Oct. 18, 2020

ISBN: 978-1-73518-390-9

Page Count: 442

Publisher: Tensile Press

Review Posted Online: March 10, 2021

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THE SECRET OF SECRETS

A standout in the series.

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The sixth adventure of Harvard symbology professor Robert Langdon explores the mysteries of human consciousness, the demonic projects of the CIA, and the city of Prague.

“Ladies and gentlemen...we are about to experience a sea change in our understanding of how the brain works, the nature of consciousness, and in fact…the very nature of reality itself.” But first—Langdon’s in love! Brown’s devoted readers first met brilliant noetic scientist Katherine Solomon in The Lost Symbol (2009); she’s back as a serious girlfriend, engaging the committed bachelor in a way not seen before. The book opens with the pair in a luxurious suite at the Four Seasons in Prague. It’s the night after Katherine has delivered the lecture quoted above, setting the theme for the novel, which features a plethora of real-life cases and anomalies that seem to support the notion that human consciousness is not localized inside the human skull. Brown’s talent for assembling research is also evident in this novel’s alter ego as a guidebook to Prague, whose history and attractions are described in great and glowing detail. Whether you appreciate or skim past the innumerable info dumps on these and other topics (Jewish folklore fans—the Golem is in the house!), it goes without saying that concision is not a goal in the Dan Brown editing process. Speaking of editing, the nearly 700-page book is dedicated to Brown’s editor, who seems to appear as a character—to put it in the italicized form used for Brownian insight, Jason Kaufman must be Jonas Faukman! A major subplot involves the theft of Katherine’s manuscript from the secure servers of Penguin Random House; the delightful Faukman continues to spout witty wisecracks even when blindfolded and hogtied. There’s no shortage of action, derring-do, explosions, high-tech torture machines, attempted and successful murders, and opportunities for split-second, last-minute escapes; good thing Langdon, this aging symbology wonk, never misses swimming his morning laps. Readers who are not already dyed-in-the-wool Langdonites may find themselves echoing the prof’s own conclusion regarding the credibility of all this paranormal hoo-ha: At some point, skepticism itself becomes irrational.

A standout in the series.

Pub Date: Sept. 9, 2025

ISBN: 9780385546898

Page Count: 688

Publisher: Doubleday

Review Posted Online: Sept. 9, 2025

Kirkus Reviews Issue: Nov. 1, 2025

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GONE BEFORE GOODBYE

Maybe not the most thrilling thriller, but the role of AI in coping with grief gives this novel pathos and interest.

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A widowed and disgraced plastic surgeon is drawn into a Russian oligarch’s evil schemes.

Witherspoon’s adult fiction debut, co-authored with thrillermeister Coben, opens as heart surgery performed by Dr. Marc Adams in a North African refugee camp is interrupted by the explosive invasion of armed militants. It's the last we will see of Marc in this dimension. The next chapter jumps ahead one year to a ceremony at Johns Hopkins University in Baltimore where his widow, Maggie McCabe, is supposed to be presenting an award in honor of her mother. Miserable and anxious about appearing in public after having lost her medical license, she consults with her late husband on her phone—not via supernatural means, but using a "griefbot," an amazingly lifelike and functional AI app created by her genius sister, Sharon. Once the griefbot coaxes her to brave the sneering masses, she learns she’s been replaced on the podium anyway. But she runs into a former professor, a celebrity plastic surgeon, who requests a meeting with her at his office in New York and won’t take no for an answer. Next thing she knows, there’s $10 million in her bank account and she’s on a private plane heading to a palace outside Moscow where she’s been engaged to perform off-the-record surgery on billionaire Oleg Ragoravich (new face) and his girlfriend, Nadia (new boobs). And…we’re off. A whirl of surgeries, chases, and escapes ensues as Maggie gradually comes to understand who these people are and what they have in mind for her, and how it connects to Marc and their missing friend and business partner, Trace Packer. She is aided by her delightful father-in-law, Porkchop, owner of a biker bar in New York City and a very handy guy to have on your team if you've run afoul of an international criminal organization. From the palace in Rublevka the action moves to Dubai and then Bordeaux, climaxing in a high-stakes illegal heart transplant. But wait—is Marc really dead? What happened to Trace? Who is Nadia really? Though these smoldering questions don’t quite catch fire, it's a good first try for Witherspoon.

Maybe not the most thrilling thriller, but the role of AI in coping with grief gives this novel pathos and interest.

Pub Date: Oct. 14, 2025

ISBN: 9781538774700

Page Count: 352

Publisher: Grand Central Publishing

Review Posted Online: Oct. 15, 2025

Kirkus Reviews Issue: Dec. 1, 2025

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