A fine life, warts and all, of a brilliant scientist and his fight against cancer.
A long-overdue biography of German biologist Otto Warburg (1883-1970), who won the Nobel Prize for his work on cell respiration and metabolism, especially as related to cancer.
Self-confident and assertive, Warburg made his first groundbreaking discovery—that fertilized eggs vastly increased their oxygen consumption—even before receiving his medical degree. By the 1920s, his work on cell metabolism and cancer persuaded the Rockefeller Foundation to give him a yearly grant, followed by funds to build his own research facility at the Kaiser Wilhelm institutes in Berlin. Though occasionally harassed by Nazi officials, he was likely protected by Hitler, a hypochondriac terrified of cancer. Of more than 100 Jews at the institutes in 1933, he was the only one remaining in 1945. As health and science writer Apple shows, the postwar years produced little change in Warburg’s routine, and theories about the pathogenesis of cancer dominated research until the 1960s, when scientists turned their attention to DNA and cancer-causing genes. Since cancer remains unconquered, the 21st century has seen a “metabolism revival.” Apple begins and ends with sections on the nature of cancer, the incidence of which increases as technology progresses. This realization two centuries ago began an intense search for the cause, which is still in progress. The fact that “70 percent or more of cancers were caused by environment factors, a category that includes diet,” is less helpful than it sounds, although avoiding smoking, radiation, and toxic chemicals is recommended. Health gurus confidently prescribe “anticancer diets,” but good research turns up few specifics. Diabetes and obesity increase the risk, so there’s clearly a connection to overnutrition, but Apple admits that the “connection” needs serious narrowing. As the search continues, this book is a welcome addition to the library on the disease and one of its most successful enemies.
A fine life, warts and all, of a brilliant scientist and his fight against cancer.Pub Date: May 25, 2021
ISBN: 978-1-63149-315-7
Page Count: 384
Publisher: Liveright/Norton
Review Posted Online: March 16, 2021
Kirkus Reviews Issue: April 1, 2021
BOOK REVIEW
BOOK REVIEW
BOOK REVIEW
A horde-pleaser, well-written and full of surprises.
“The Mongols swept across the globe as conquerors,” writes the appreciative pop anthropologist-historian Weatherford (The History of Money, 1997, etc.), “but also as civilization’s unrivaled cultural carriers.”
No business-secrets fluffery here, though Weatherford does credit Genghis Khan and company for seeking “not merely to conquer the world but to impose a global order based on free trade, a single international law, and a universal alphabet with which to write all the languages of the world.” Not that the world was necessarily appreciative: the Mongols were renowned for, well, intemperance in war and peace, even if Weatherford does go rather lightly on the atrocities-and-butchery front. Instead, he accentuates the positive changes the Mongols, led by a visionary Genghis Khan, brought to the vast territories they conquered, if ever so briefly: the use of carpets, noodles, tea, playing cards, lemons, carrots, fabrics, and even a few words, including the cheer hurray. (Oh, yes, and flame throwers, too.) Why, then, has history remembered Genghis and his comrades so ungenerously? Whereas Geoffrey Chaucer considered him “so excellent a lord in all things,” Genghis is a byword for all that is savage and terrible; the word “Mongol” figures, thanks to the pseudoscientific racism of the 19th century, as the root of “mongoloid,” a condition attributed to genetic throwbacks to seed sown by Mongol invaders during their decades of ravaging Europe. (Bad science, that, but Dr. Down’s son himself argued that imbeciles “derived from an earlier form of the Mongol stock and should be considered more ‘pre-human, rather than human.’ ”) Weatherford’s lively analysis restores the Mongols’ reputation, and it takes some wonderful learned detours—into, for instance, the history of the so-called Secret History of the Mongols, which the Nazis raced to translate in the hope that it would help them conquer Russia, as only the Mongols had succeeded in doing.
A horde-pleaser, well-written and full of surprises.Pub Date: March 2, 2004
ISBN: 0-609-61062-7
Page Count: 320
Publisher: Crown
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Dec. 1, 2003
BOOK REVIEW
BOOK REVIEW
BOOK REVIEW
Yes: it's high time for a de-romanticized, de-mythified, close-up retelling of the U.S. Space Program's launching—the inside story of those first seven astronauts.
But no: jazzy, jivey, exclamation-pointed, italicized Tom Wolfe "Mr. Overkill" hasn't really got the fight stuff for the job. Admittedly, he covers all the ground. He begins with the competitive, macho world of test pilots from which the astronauts came (thus being grossly overqualified to just sit in a controlled capsule); he follows the choosing of the Seven, the preparations for space flight, the flights themselves, the feelings of the wives; and he presents the breathless press coverage, the sudden celebrity, the glorification. He even throws in some of the technology. But instead of replacing the heroic standard version with the ring of truth, Wolfe merely offers an alternative myth: a surreal, satiric, often cartoony Wolfe-arama that, especially since there isn't a bit of documentation along the way, has one constantly wondering if anything really happened the way Wolfe tells it. His astronauts (referred to as "the brethren" or "The True Brothers") are obsessed with having the "right stuff" that certain blend of guts and smarts that spells pilot success. The Press is a ravenous fool, always referred to as "the eternal Victorian Gent": when Walter Cronkite's voice breaks while reporting a possible astronaut death, "There was the Press the Genteel Gent, coming up with the appropriate emotion. . . live. . . with no prompting whatsoever!" And, most off-puttingly, Wolfe presumes to enter the minds of one and all: he's with near-drowing Gus Grissom ("Cox. . . That face up there!—it's Cox. . . Cox knew how to get people out of here! . . . Cox! . . ."); he's with Betty Grissom angry about not staying at Holiday Inn ("Now. . . they truly owed her"); and, in a crude hatchet-job, he's with John Glenn furious at Al Shepard's being chosen for the first flight, pontificating to the others about their licentious behavior, or holding onto his self-image during his flight ("Oh, yes! I've been here before! And I am immune! I don't get into corners I can't get out of! . . . The Presbyterian Pilot was not about to foul up. His pipeline to dear Lord could not be clearer"). Certainly there's much here that Wolfe is quite right about, much that people will be interested in hearing: the P-R whitewash of Grissom's foul-up, the Life magazine excesses, the inter-astronaut tensions. And, for those who want to give Wolfe the benefit of the doubt throughout, there are emotional reconstructions that are juicily shrill.
But most readers outside the slick urban Wolfe orbit will find credibility fatally undermined by the self-indulgent digressions, the stylistic excesses, and the broadly satiric, anti-All-American stance; and, though The Right Stuff has enough energy, sass, and dirt to attract an audience, it mostly suggests that until Wolfe can put his subject first and his preening writing-persona second, he probably won't be a convincing chronicler of anything much weightier than radical chic.
Pub Date: Sept. 24, 1979
ISBN: 0312427565
Page Count: 370
Publisher: Farrar, Straus and Giroux
Review Posted Online: Oct. 13, 2011
Kirkus Reviews Issue: Sept. 1, 1979
BOOK TO SCREEN
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