ADVERSE REACTIONS

Intense scrutiny of the rise and fall of the antibiotic chloramphenicol (trade name: Chloromycetin) that raises tough questions about the marketing and use of drugs. Maeder (Children of Psychiatrists, 1988; The Unspeakable Crimes of Dr. Petiot, 1980) traces the story of chloramphenicol since its development by Parke-Davis in the late 1940s. Acclaimed as a wonder drug, it was the first broad-spectrum antibiotic and was indeed potent. The problem was that in a small proportion of patients it caused aplastic anemia, a fatal blood disorder. Parke-Davis, which was a large, powerful, and highly respected pharmaceutical house in the 1940s and 1950s, promoted the drug vigorously and in glowing terms, and doctors listened and believed. Maeder recounts in great detail how, despite repeated warnings from the Food and Drug Administration and the American Medical Association, studies by the National Research Council, decades of congressional hearings, countless lawsuits, and reams of adverse publicity in both the popular press and professional journals, doctors continued to prescribe it. The book is filled with memorable passages—gruesome accounts of the deaths of children, anguished and angry letters from distraught parents, and sparring matches between Senator Estes Kefauver and the president of Parke-Davis and between Senator Gaylord Nelson and the firm's head of quality control. Today, chloramphenicol has largely disappeared in the United States (though not overseas), as other, even more potent drugs have taken its place, but the basic questions Maeder raises remain unanswered: what risks are acceptable, and how can the public be protected against unacceptable ones? Perhaps wisely, Maeder does not pretend to have the solution, but he recommends improved reporting of adverse reactions to the FDA and better controls on doctors' prescribing behavior and on promotional activities of pharmaceutical companies. Meticulously researched and documented; a valuable addendum to the literature on drug safety.

Pub Date: April 26, 1994

ISBN: 0-688-11682-5

Page Count: 480

Publisher: Morrow/HarperCollins

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: Feb. 15, 1994

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Not an easy read but an essential one.

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HOW TO BE AN ANTIRACIST

Title notwithstanding, this latest from the National Book Award–winning author is no guidebook to getting woke.

In fact, the word “woke” appears nowhere within its pages. Rather, it is a combination memoir and extension of Atlantic columnist Kendi’s towering Stamped From the Beginning (2016) that leads readers through a taxonomy of racist thought to anti-racist action. Never wavering from the thesis introduced in his previous book, that “racism is a powerful collection of racist policies that lead to racial inequity and are substantiated by racist ideas,” the author posits a seemingly simple binary: “Antiracism is a powerful collection of antiracist policies that lead to racial equity and are substantiated by antiracist ideas.” The author, founding director of American University’s Antiracist Research and Policy Center, chronicles how he grew from a childhood steeped in black liberation Christianity to his doctoral studies, identifying and dispelling the layers of racist thought under which he had operated. “Internalized racism,” he writes, “is the real Black on Black Crime.” Kendi methodically examines racism through numerous lenses: power, biology, ethnicity, body, culture, and so forth, all the way to the intersectional constructs of gender racism and queer racism (the only section of the book that feels rushed). Each chapter examines one facet of racism, the authorial camera alternately zooming in on an episode from Kendi’s life that exemplifies it—e.g., as a teen, he wore light-colored contact lenses, wanting “to be Black but…not…to look Black”—and then panning to the history that informs it (the antebellum hierarchy that valued light skin over dark). The author then reframes those received ideas with inexorable logic: “Either racist policy or Black inferiority explains why White people are wealthier, healthier, and more powerful than Black people today.” If Kendi is justifiably hard on America, he’s just as hard on himself. When he began college, “anti-Black racist ideas covered my freshman eyes like my orange contacts.” This unsparing honesty helps readers, both white and people of color, navigate this difficult intellectual territory.

Not an easy read but an essential one.

Pub Date: Aug. 13, 2019

ISBN: 978-0-525-50928-8

Page Count: 320

Publisher: One World/Random House

Review Posted Online: April 28, 2019

Kirkus Reviews Issue: May 15, 2019

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A clear and candid contribution to an essential conversation.

SO YOU WANT TO TALK ABOUT RACE

Straight talk to blacks and whites about the realities of racism.

In her feisty debut book, Oluo, essayist, blogger, and editor at large at the Establishment magazine, writes from the perspective of a black, queer, middle-class, college-educated woman living in a “white supremacist country.” The daughter of a white single mother, brought up in largely white Seattle, she sees race as “one of the most defining forces” in her life. Throughout the book, Oluo responds to questions that she has often been asked, and others that she wishes were asked, about racism “in our workplace, our government, our homes, and ourselves.” “Is it really about race?” she is asked by whites who insist that class is a greater source of oppression. “Is police brutality really about race?” “What is cultural appropriation?” and “What is the model minority myth?” Her sharp, no-nonsense answers include talking points for both blacks and whites. She explains, for example, “when somebody asks you to ‘check your privilege’ they are asking you to pause and consider how the advantages you’ve had in life are contributing to your opinions and actions, and how the lack of disadvantages in certain areas is keeping you from fully understanding the struggles others are facing.” She unpacks the complicated term “intersectionality”: the idea that social justice must consider “a myriad of identities—our gender, class, race, sexuality, and so much more—that inform our experiences in life.” She asks whites to realize that when people of color talk about systemic racism, “they are opening up all of that pain and fear and anger to you” and are asking that they be heard. After devoting most of the book to talking, Oluo finishes with a chapter on action and its urgency. Action includes pressing for reform in schools, unions, and local governments; boycotting businesses that exploit people of color; contributing money to social justice organizations; and, most of all, voting for candidates who make “diversity, inclusion and racial justice a priority.”

A clear and candid contribution to an essential conversation.

Pub Date: Jan. 16, 2018

ISBN: 978-1-58005-677-9

Page Count: 256

Publisher: Seal Press

Review Posted Online: Oct. 9, 2017

Kirkus Reviews Issue: Nov. 1, 2017

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