HANNAH'S HEIRS

THE QUEST FOR THE GENETIC ORIGINS OF ALZHEIMER'S DISEASE

High technology and human tragedy; luck and persistence; altruism and competition—they all come together in this absorbing tale of medical detection that spans decades and crosses continents. In 1985, Pollen (Neurology and Physiology/UMass Medical Center) examined an Alzheimer's patient who brought with him a multigenerational family tree representing the most extensive known pedigree of the disease. The records began with ``Hannah,'' an ancestor born in Byelorussia 150 years ago, and included data on dozens of her descendants, living and dead—information, Pollen immediately realized, of great significance to geneticists. Here, he recounts a two-fold tale—that of geneticists determined to find the abnormal gene that causes familial-based Alzheimer's, and of an afflicted family determined to help them. Science basics are provided in a brief look at the work of Gregor Mendel, the founder of genetic science, and of Alois Alzheimer, the 19th-century Bavarian physician who identified the dementia that bears his name. Occasionally, the technicalities of modern molecular genetics may slow the general reader down, but Pollen doesn't lose sight of the human story: In one chapter, he describes his own mother's descent into dementia. The author also explains that, despite the 1991 linking by British researchers of a mutation in a specific gene to one form of familial Alzheimer's, the key to the vast majority of cases remains to be found. Teams of researchers in England, Belgium, Canada, and the US are competing fiercely to be the first with new findings, prompting Pollen to question the roles of competition and cooperation in modern medical research. In spite of some difficult technical passages: an exciting story that reveals much about how science is done—and that says something affirmative about the human spirit as well. (Eleven illustrations—not seen).

Pub Date: July 1, 1993

ISBN: 0-19-506809-2

Page Count: 224

Publisher: Oxford Univ.

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: May 1, 1993

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Loads of good explaining, with reminders, time and again, of how much remains unknown, neatly putting the death of science...

A SHORT HISTORY OF NEARLY EVERYTHING

Bryson (I'm a Stranger Here Myself, 1999, etc.), a man who knows how to track down an explanation and make it confess, asks the hard questions of science—e.g., how did things get to be the way they are?—and, when possible, provides answers.

As he once went about making English intelligible, Bryson now attempts the same with the great moments of science, both the ideas themselves and their genesis, to resounding success. Piqued by his own ignorance on these matters, he’s egged on even more so by the people who’ve figured out—or think they’ve figured out—such things as what is in the center of the Earth. So he goes exploring, in the library and in company with scientists at work today, to get a grip on a range of topics from subatomic particles to cosmology. The aim is to deliver reports on these subjects in terms anyone can understand, and for the most part, it works. The most difficult is the nonintuitive material—time as part of space, say, or proteins inventing themselves spontaneously, without direction—and the quantum leaps unusual minds have made: as J.B.S. Haldane once put it, “The universe is not only queerer than we suppose; it is queerer than we can suppose.” Mostly, though, Bryson renders clear the evolution of continental drift, atomic structure, singularity, the extinction of the dinosaur, and a mighty host of other subjects in self-contained chapters that can be taken at a bite, rather than read wholesale. He delivers the human-interest angle on the scientists, and he keeps the reader laughing and willing to forge ahead, even over their heads: the human body, for instance, harboring enough energy “to explode with the force of thirty very large hydrogen bombs, assuming you knew how to liberate it and really wished to make a point.”

Loads of good explaining, with reminders, time and again, of how much remains unknown, neatly putting the death of science into perspective.

Pub Date: May 6, 2003

ISBN: 0-7679-0817-1

Page Count: 304

Publisher: Broadway

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: April 1, 2003

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A tiny book, not much bigger than a pamphlet, with huge potential impact.

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NO ONE IS TOO SMALL TO MAKE A DIFFERENCE

A collection of articulate, forceful speeches made from September 2018 to September 2019 by the Swedish climate activist who was nominated for a Nobel Peace Prize.

Speaking in such venues as the European and British Parliaments, the French National Assembly, the Austrian World Summit, and the U.N. General Assembly, Thunberg has always been refreshingly—and necessarily—blunt in her demands for action from world leaders who refuse to address climate change. With clarity and unbridled passion, she presents her message that climate change is an emergency that must be addressed immediately, and she fills her speeches with punchy sound bites delivered in her characteristic pull-no-punches style: “I don’t want you to be hopeful. I want you to panic. I want you to feel the fear I feel every day. And then I want you to act.” In speech after speech, to persuade her listeners, she cites uncomfortable, even alarming statistics about global temperature rise and carbon dioxide emissions. Although this inevitably makes the text rather repetitive, the repetition itself has an impact, driving home her point so that no one can fail to understand its importance. Thunberg varies her style for different audiences. Sometimes it is the rousing “our house is on fire” approach; other times she speaks more quietly about herself and her hopes and her dreams. When addressing the U.S. Congress, she knowingly calls to mind the words and deeds of Martin Luther King Jr. and John F. Kennedy. The last speech in the book ends on a note that is both challenging and upbeat: “We are the change and change is coming.” The edition published in Britain earlier this year contained 11 speeches; this updated edition has 16, all worth reading.

A tiny book, not much bigger than a pamphlet, with huge potential impact.

Pub Date: Nov. 26, 2019

ISBN: 978-0-14-313356-8

Page Count: 112

Publisher: Penguin

Review Posted Online: Nov. 3, 2019

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