A readable, provocative look at biological tinkering that will doubtless shape the future, whether we like it or not.
Lucid study of recent efforts to alter the human gene to end hereditary diseases, a project fraught with ethical and medical implications.
Kirksey, an anthropologist who is often called upon to speak to humanistic, rather than strictly biological, views of human nature, explores a most human problem: the use of the new CRISPR technology to alter genes to remove undesirable features. “CRISPR is an enzyme that produces targeted mutagenesis,” he writes. “In other words, CRISPR generates mutants.” These mutants are not yet at the level of the famed X-Men, though they touch on a point in common. As Kirksey observes, the X-Men series “was created by two American Jewish men in 1963 as a parable about civil rights.” And what of the civil rights of the gene-edited babies produced recently in a Chinese laboratory? They have been carefully hidden away, for “the families desperately wanted to protect the identity of their children to prevent discriminatory treatment by society.” Kirksey’s primary narrative follows Jiankui He, the Chinese scientist responsible for the in vitro gene-edited procedure that produced a set of twins. Dr. He, a brilliant man who raised himself out of poverty through sheer effort, may have started with the best of intentions, but the gene-editing enterprise quickly became a profit center snapped up by excited corporations. Editing, writes the author, may not be the best metaphor: “CRISPR is more like a tiny Reaper drone that can produce targeted damage to DNA,” sometimes hitting precisely and sometimes inadvertently destroying good cells on either side. Whatever the case, scientists are already looking at eliminating existing mutations, “from primordial dwarfism to obscure conditions like CAMRQ (cerebellar ataxia, intellectual disability, and dysequilibrium syndrome),” a business without visible end and, of course, available first to those with the greatest financial resources.
A readable, provocative look at biological tinkering that will doubtless shape the future, whether we like it or not.Pub Date: Nov. 10, 2020
ISBN: 978-1-250-26535-7
Page Count: 304
Publisher: St. Martin's
Review Posted Online: Sept. 28, 2020
Kirkus Reviews Issue: Oct. 15, 2020
A virtuoso performance and an ode to an undervalued medium created by two talented artists.
The veteran actor, comedian, and banjo player teams up with the acclaimed illustrator to create a unique book of cartoons that communicates their personalities.
Martin, also a prolific author, has always been intrigued by the cartoons strewn throughout the pages of the New Yorker. So when he was presented with the opportunity to work with Bliss, who has been a staff cartoonist at the magazine since 1997, he seized the moment. “The idea of a one-panel image with or without a caption mystified me,” he writes. “I felt like, yeah, sometimes I’m funny, but there are these other weird freaks who are actually funny.” Once the duo agreed to work together, they established their creative process, which consisted of working forward and backward: “Forwards was me conceiving of several cartoon images and captions, and Harry would select his favorites; backwards was Harry sending me sketched or fully drawn cartoons for dialogue or banners.” Sometimes, he writes, “the perfect joke occurs two seconds before deadline.” There are several cartoons depicting this method, including a humorous multipanel piece highlighting their first meeting called “They Meet,” in which Martin thinks to himself, “He’ll never be able to translate my delicate and finely honed droll notions.” In the next panel, Bliss thinks, “I’m sure he won’t understand that the comic art form is way more subtle than his blunt-force humor.” The team collaborated for a year and created 150 cartoons featuring an array of topics, “from dogs and cats to outer space and art museums.” A witty creation of a bovine family sitting down to a gourmet meal and one of Dumbo getting his comeuppance highlight the duo’s comedic talent. What also makes this project successful is the team’s keen understanding of human behavior as viewed through their unconventional comedic minds.
A virtuoso performance and an ode to an undervalued medium created by two talented artists.Pub Date: Nov. 17, 2020
ISBN: 978-1-250-26289-9
Page Count: 272
Publisher: Celadon Books
Review Posted Online: Aug. 30, 2020
Kirkus Reviews Issue: Sept. 15, 2020
PERSPECTIVES
Sedaris at his darkest—and his best.
In which the veteran humorist enters middle age with fine snark but some trepidation as well.
Mortality is weighing on Sedaris (Theft by Finding: Diaries 1977-2002, 2017, etc.), much of it his own, professional narcissist that he is. Watching an elderly man have a bowel accident on a plane, he dreaded the day when he would be the target of teenagers’ jokes “as they raise their phones to take my picture from behind.” A skin tumor troubled him, but so did the doctor who told him he couldn’t keep it once it was removed. “But it’s my tumor,” he insisted. “I made it.” (Eventually, he found a semitrained doctor to remove and give him the lipoma, which he proceeded to feed to a turtle.) The deaths of others are much on the author’s mind as well: He contemplates the suicide of his sister Tiffany, his alcoholic mother’s death, and his cantankerous father’s erratic behavior. His contemplation of his mother’s drinking—and his family’s denial of it—makes for some of the most poignant writing in the book: The sound of her putting ice in a rocks glass increasingly sounded “like a trigger being cocked.” Despite the gloom, however, frivolity still abides in the Sedaris clan. His summer home on the Carolina coast, which he dubbed the Sea Section, overspills with irreverent bantering between him and his siblings as his long-suffering partner, Hugh, looks on. Sedaris hasn’t lost his capacity for bemused observations of the people he encounters. For example, cashiers who say “have a blessed day” make him feel “like you’ve been sprayed against your will with God cologne.” But bad news has sharpened the author’s humor, and this book is defined by a persistent, engaging bafflement over how seriously or unseriously to take life when it’s increasingly filled with Trump and funerals.
Sedaris at his darkest—and his best.Pub Date: May 29, 2018
ISBN: 978-0-316-39238-9
Page Count: 288
Publisher: Little, Brown
Review Posted Online: Feb. 19, 2018
Kirkus Reviews Issue: March 1, 2018
PROFILES
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