A thorough and nuanced presentation of the state of the science of cancer research, refreshing in its honest appraisal that...

THE CANCER CHRONICLES

UNLOCKING MEDICINE'S DEEPEST MYSTERY

Not quite “abandon all hope,” but there’s not much to cheer about in this wide-angled survey of where we are in the fight against cancer.

Science writer Johnson (The Ten Most Beautiful Experiments, 2008, etc.) has steeped himself in cancer lore, attended conferences and interviewed experts to conclude that the more we learn about the disease, the more complex it gets. Yes, there have been declines in incidence, but new cases will offset those declines simply because people are living longer; cancers essentially reflect the accumulation of DNA hits to a cell as it divides and divides again over time. Johnson's involvement took off with the discovery of a rare uterine cancer in his wife, Nancy, which, when diagnosed, had metastasized to her groin. The detailed chapters on her surgery and multiple drug and radiation therapies enable Johnson to explain why such triple-prong treatment is standard today and what new drugs are in the pipeline. Nancy’s story may have also inspired his reporting on risk factors and cancer prevention. Here, the facts may shock: Cigarette smoking, ionizing radiation and certain viruses are serious cancer risks, but the contributions of other known carcinogens, environmental pollutants and conjectured microwave transmissions via cellphones are minor or unproven. Furthermore, there is no evidence that eating 5-per-day servings of fruits and vegetables will prevent cancer. Instead, researchers see cancer as an evolutionary process in which increasingly aberrant cell lines may compete or cooperate, stimulate the development of a blood supply and acquire the ability to metastasize. Factors that may encourage this behavior include hormones like estrogen, which stimulates cell division, and changes in metabolism due to obesity; insulin resistance may also play a role. But for the majority of cancers, as was the case with the head and neck cancer that ended the life of Johnson’s younger brother, the cause is unknown, a random event.

A thorough and nuanced presentation of the state of the science of cancer research, refreshing in its honest appraisal that the war is far from over.

Pub Date: Aug. 30, 2013

ISBN: 978-0-307-59514-0

Page Count: 304

Publisher: Knopf

Review Posted Online: June 8, 2013

Kirkus Reviews Issue: June 15, 2013

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Stricter than, say, Bergen Evans or W3 ("disinterested" means impartial — period), Strunk is in the last analysis...

THE ELEMENTS OF STYLE

50TH ANNIVERSARY EDITION

Privately published by Strunk of Cornell in 1918 and revised by his student E. B. White in 1959, that "little book" is back again with more White updatings.

Stricter than, say, Bergen Evans or W3 ("disinterested" means impartial — period), Strunk is in the last analysis (whoops — "A bankrupt expression") a unique guide (which means "without like or equal").

Pub Date: May 15, 1972

ISBN: 0205632645

Page Count: 105

Publisher: Macmillan

Review Posted Online: Oct. 28, 2011

Kirkus Reviews Issue: May 1, 1972

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WHAT A WONDERFUL WORLD

A LIFETIME OF RECORDINGS

Noted jazz and pop record producer Thiele offers a chatty autobiography. Aided by record-business colleague Golden, Thiele traces his career from his start as a ``pubescent, novice jazz record producer'' in the 1940s through the '50s, when he headed Coral, Dot, and Roulette Records, and the '60s, when he worked for ABC and ran the famous Impulse! jazz label. At Coral, Thiele championed the work of ``hillbilly'' singer Buddy Holly, although the only sessions he produced with Holly were marred by saccharine strings. The producer specialized in more mainstream popsters like the irrepressibly perky Teresa Brewer (who later became his fourth wife) and the bubble-machine muzak-meister Lawrence Welk. At Dot, Thiele was instrumental in recording Jack Kerouac's famous beat- generation ramblings to jazz accompaniment (recordings that Dot's president found ``pornographic''), while also overseeing a steady stream of pop hits. He then moved to the Mafia-controlled Roulette label, where he observed the ``silk-suited, pinky-ringed'' entourage who frequented the label's offices. Incredibly, however, Thiele remembers the famously hard-nosed Morris Levy, who ran the label and was eventually convicted of extortion, as ``one of the kindest, most warm-hearted, and classiest music men I have ever known.'' At ABC/Impulse!, Thiele oversaw the classic recordings of John Coltrane, although he is the first to admit that Coltrane essentially produced his own sessions. Like many producers of the day, Thiele participated in the ownership of publishing rights to some of the songs he recorded; he makes no apology for this practice, which he calls ``entirely appropriate and without any ethical conflicts.'' A pleasant, if not exactly riveting, memoir that will be of most interest to those with a thirst for cocktail-hour stories of the record biz. (25 halftones, not seen)

Pub Date: May 1, 1995

ISBN: 0-19-508629-4

Page Count: 224

Publisher: Oxford Univ.

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: March 1, 1995

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