An important book about a major scientific advance but not for the faint of heart. Readers not up to speed on high school...

A CRACK IN CREATION

GENE EDITING AND THE UNTHINKABLE POWER TO CONTROL EVOLUTION

A pair of biochemists offer a fresh examination of the “newest and arguably most effective genetic-engineering tool.”

Biological spectaculars—e.g., genetic engineering, cloned sheep, in vitro fertilization—have produced headlines and bestsellers but flopped where it counts: they don’t save many lives. CRISPR (clustered regularly interspaced short palindromic repeats) is changing that, write Doudna (Chemistry and Molecular Biology/Univ. of California; co-author: Molecular Biology: Principles and Practice, 2011, etc.) and Sternberg in this enthusiastic and definitely not dumbed-down account of gene manipulation that, unlike earlier methods, is precise and easy. In the first half of the book, “The Tool,” the authors summarize a century of research but focus on the discovery, in the early 2000s, that bacteria possess an ingenious immune system that destroys invading viruses by cutting their DNA into pieces. Within the past decade, researchers converted this into an ingenious technique for literally debugging DNA: putting in good genes in the place of bad. “Because CRISPR allows precise and relatively straightforward DNA editing,” write the authors, “it has transformed every genetic disease—at least, every disease for which we know the underlying mutation—into a potentially treatable target.” The second half, “The Task,” describes the miraculous powers of CRISPR to cure disease and control evolution—but not yet. Replacing a single defective gene cures muscular dystrophy in mice; clinical trials in humans for this and similar disorders (sickle-cell, hemophilia, cystic fibrosis) are in the works. CRISPR can’t yet cure cancer, prevent AIDS, wipe out malaria, revive the wooly mammoth, or regenerate a limb, but an avalanche of startups (Doudna’s included) is betting billions that it eventually will.

An important book about a major scientific advance but not for the faint of heart. Readers not up to speed on high school biology should prepare themselves with a good popular primer on DNA, such as Matthew Cobb’s Life’s Greatest Secret (2015).

Pub Date: June 13, 2017

ISBN: 978-0-544-71694-0

Page Count: 320

Publisher: Houghton Mifflin Harcourt

Review Posted Online: March 15, 2017

Kirkus Reviews Issue: April 1, 2017

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A quirky wonder of a book.

WHY FISH DON'T EXIST

A STORY OF LOSS, LOVE, AND THE HIDDEN ORDER OF LIFE

A Peabody Award–winning NPR science reporter chronicles the life of a turn-of-the-century scientist and how her quest led to significant revelations about the meaning of order, chaos, and her own existence.

Miller began doing research on David Starr Jordan (1851-1931) to understand how he had managed to carry on after the 1906 San Francisco earthquake destroyed his work. A taxonomist who is credited with discovering “a full fifth of fish known to man in his day,” Jordan had amassed an unparalleled collection of ichthyological specimens. Gathering up all the fish he could save, Jordan sewed the nameplates that had been on the destroyed jars directly onto the fish. His perseverance intrigued the author, who also discusses the struggles she underwent after her affair with a woman ended a heterosexual relationship. Born into an upstate New York farm family, Jordan attended Cornell and then became an itinerant scholar and field researcher until he landed at Indiana University, where his first ichthyological collection was destroyed by lightning. In between this catastrophe and others involving family members’ deaths, he reconstructed his collection. Later, he was appointed as the founding president of Stanford, where he evolved into a Machiavellian figure who trampled on colleagues and sang the praises of eugenics. Miller concludes that Jordan displayed the characteristics of someone who relied on “positive illusions” to rebound from disaster and that his stand on eugenics came from a belief in “a divine hierarchy from bacteria to humans that point[ed]…toward better.” Considering recent research that negates biological hierarchies, the author then suggests that Jordan’s beloved taxonomic category—fish—does not exist. Part biography, part science report, and part meditation on how the chaos that caused Miller’s existential misery could also bring self-acceptance and a loving wife, this unique book is an ingenious celebration of diversity and the mysterious order that underlies all existence.

A quirky wonder of a book.

Pub Date: April 14, 2020

ISBN: 978-1-5011-6027-1

Page Count: 224

Publisher: Simon & Schuster

Review Posted Online: Jan. 2, 2020

Kirkus Reviews Issue: Feb. 1, 2020

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Jahren transcends both memoir and science writing in this literary fusion of both genres.

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LAB GIRL

Award-winning scientist Jahren (Geology and Geophysics/Univ. of Hawaii) delivers a personal memoir and a paean to the natural world.

The author’s father was a physics and earth science teacher who encouraged her play in the laboratory, and her mother was a student of English literature who nurtured her love of reading. Both of these early influences engrossingly combine in this adroit story of a dedication to science. Jahren’s journey from struggling student to struggling scientist has the narrative tension of a novel and characters she imbues with real depth. The heroes in this tale are the plants that the author studies, and throughout, she employs her facility with words to engage her readers. We learn much along the way—e.g., how the willow tree clones itself, the courage of a seed’s first root, the symbiotic relationship between trees and fungi, and the airborne signals used by trees in their ongoing war against insects. Trees are of key interest to Jahren, and at times she waxes poetic: “Each beginning is the end of a waiting. We are each given exactly one chance to be. Each of us is both impossible and inevitable. Every replete tree was first a seed that waited.” The author draws many parallels between her subjects and herself. This is her story, after all, and we are engaged beyond expectation as she relates her struggle in building and running laboratory after laboratory at the universities that have employed her. Present throughout is her lab partner, a disaffected genius named Bill, whom she recruited when she was a graduate student at Berkeley and with whom she’s worked ever since. The author’s tenacity, hope, and gratitude are all evident as she and Bill chase the sweetness of discovery in the face of the harsh economic realities of the research scientist.

Jahren transcends both memoir and science writing in this literary fusion of both genres.

Pub Date: April 5, 2016

ISBN: 978-1-101-87493-6

Page Count: 336

Publisher: Knopf

Review Posted Online: Jan. 5, 2016

Kirkus Reviews Issue: Jan. 15, 2016

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