While revealing a disconcerting dearth of scientific knowledge about its causes, Cohen’s work on miscarriage is a worthwhile...
A deft melding of what researchers are learning about miscarriage, persistent misconceptions about it, and deeply personal stories of women who have repeatedly miscarried.
Science writer Cohen (Shots in the Dark: The Wayward Search for an AIDS Vaccine, 2001) began delving into the subject of miscarriages after his wife had four in a row. Besides exploring the scientific literature, he interviewed and observed doctors working with their patients at clinics (in Boston, Vancouver, and London) that specialize in recurrent miscarriage; he also interviewed nearly one hundred women and their partners about the experience of miscarrying. In “Mother Nature,” Cohen looks at the biology of the female reproductive system, focusing on the mechanisms of miscarriage. Abnormal chromosomes, he reports, are the cause half the time or more, and, as women age, the frequency of abnormalities in their eggs increases. As for other causes, science has few clear-cut answers. In “Mysteries,” Cohen examines and rejects various ideas about causes, including a woman’s faulty immune system and contaminants in the environment. Fetuses, he says, are more rugged than we think, and the environment provided by the female body is remarkably protective. He also offers a warning tale about abortion interventions: the drug diethylstilbestrol, known as DES, once given to women to prevent miscarriage, turned out to cause grievous harm to pregnant women and their daughters. In “Hope,” Cohen tells the stories of couples seeking help in carrying babies to term and provides a close-up look at clinicians who are trying to help them. The success stories of women who carried to term after repeated failures puts a human face on a statistic Cohen uncovered early in his research: those who have had three or more consecutive miscarriages and become pregnant again will, with no treatment, carry to term 70 percent of the time.
While revealing a disconcerting dearth of scientific knowledge about its causes, Cohen’s work on miscarriage is a worthwhile addition to the literature and his reassuring message welcome.Pub Date: Jan. 11, 2005
ISBN: 0-618-27724-2
Page Count: 288
Publisher: Houghton Mifflin
Review Posted Online: June 24, 2010
Kirkus Reviews Issue: Oct. 15, 2004
Useful but disappointingly commonplace tips.
In a follow-up to The End of Illness (2012), which explored how technological advances will transform medicine, Agus (Medicine and Engineering/Univ. of Southern California) restates time-tested but too often overlooked principles for healthy living.
The author outlines simple measures that average citizens can take to live healthier lives and extend their life spans by taking advantage of modern technology to develop personalized records. These would include a list of medical tests and recommended treatments. Agus also suggests keeping track of indicators that can be observed at home on a regular basis—e.g., changes in energy, weight, appetite and blood pressure, blood sugar and general appearance. He advises that all of this information be made available online, and it is also helpful to investigate family history and consider DNA testing where indicated. Along with maintaining a healthy weight, Agus emphasizes the importance of eating a balanced diet, with plenty of fresh fruits and vegetables and a minimum of red meat. Avoid packaged vitamins and food supplements, and if possible, grow your own vegetables or buy frozen vegetables, which will generally be fresher than those on supermarket shelves. The author also warns against processed foods that make health claims but contain additives or excessive amounts of sugar or fat. Regular mealtimes and plenty of sleep, frequent hand-washing and oral hygiene are a must; smoking and excessive time in the sun should also be avoided. Agus recommends that adults should consider taking statins and baby aspirin as preventative measures. He concludes with a decade-by-decade checklist of annual medical examinations that should be routine—e.g. blood pressure, diabetes and cholesterol screenings, from one’s 20s on; colonoscopies, prostate exams and mammograms later—and a variety of top-10 lists (for example, “Top 10 Reasons to Take a Walk”).
Useful but disappointingly commonplace tips.Pub Date: Jan. 7, 2014
ISBN: 978-1-4767-3095-0
Page Count: 128
Publisher: Simon & Schuster
Review Posted Online: Sept. 30, 2013
Kirkus Reviews Issue: Oct. 15, 2013
BOOK REVIEW
BOOK REVIEW
Oncologist Agus (Medicine and Engineering/Univ. of Southern California) predicts that the application of advanced technology for modeling complex systems will transform 21st-century medicine.
The author writes that a remark Nobel Laureate Murray Gell-Mann made to him in 2009—“Look at cancer as a system"—transformed the way he views his own specialty and the entire field of preventative medicine. It made him realize that “[r]ather than honoring the body as the exceedingly complex system that it is, we keep looking for the individual gene that has gone awry, or for the one ‘secret’ that can improve our health.” Agus writes that although the ability to sequence the entire human genome is a great step forward, it is insufficient for achieving a significant breakthrough. Even though it may start with a mutation, cancer “is a dynamic process that's happening…far from the confines of a static piece of DNA”—it involves the body's immune system, its ability to regulate cell growth, metabolism and more. Agus directs his university’s Center for Applied Molecular Medicine and is the co-founder of two personalized medicine companies, Applied Proteomics and Navigenics. His hope is that their research will contribute to developing better analytical tools for preventative medicine and for the treatment of cancers. These will address the functioning of the body as a whole, applying digital technology already used by physicists to provide virtual models of cancers and model the action of proteins that regulate cell communication in the body. He also hopes to develop tools that will provide information on the concentration of different proteins in a drop of blood taken from a patient, which may reveal the onset of disease. The author also includes some guiding principles and warnings about certain healthy practices that may not be so healthy. A refreshing change of pace in the medical field, but by venturing beyond his field of expertise to pontificate on a wide range of subjects, Agus makes his otherwise intriguing narrative difficult to follow.
Pub Date: Jan. 1, 2012
ISBN: 978-1-4516-1017-8
Page Count: 288
Publisher: Free Press
Review Posted Online: Nov. 5, 2011
Kirkus Reviews Issue: Nov. 15, 2011
BOOK REVIEW
BOOK REVIEW
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