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BIOPUNK

DIY SCIENTISTS HACK THE SOFTWARE OF LIFE

Though there are not yet any solutions to the legal and ethical issues, Wolhsen provides a timely airing of what may be...

Do-it-yourself comes to biotechnology in the form of young geeks who tinker with DNA in the garage, the kitchen or wherever they can set up a lab bench.

According to AP reporter Wohlsen, these DIY scientists are passionate biology graduates or post-docs, savvy in the ways of molecular biology and computers and possessed of a libertarian streak. They want open access to information and oppose the kind of data control and patent rights they see embodied by academics, biotech firms or government bureaucrats. In this debut, the author profiles leading “biopunks” who believe that free access to crowd-sourced information is the key to rapid innovation. Their idea of a “hack” is not the breaking and entering of a computer system for illicit purposes, but a term that means they have gotten tools and materials on the cheap and used them to develop diagnostic tests, drugs or even new organisms. Indeed they have: Wohlsen describes a cheap PCR machine (for replicating bits of DNA), a woman who devised a test for a genetic disease that runs in her family and some ingenious designs for cancer-targeting drugs. Some biopunks have formed groups like DIYbio, which makes biology accessible to citizen scientists; others are futurist “transhumanists” who dream of extending life spans and importing computer chips in their brains. If this information makes you anxious or worried about socio/legal/ethical issues, lack of regulation, privacy concerns or DIYers creating Frankensteins, Wohlsen’s discussions of these issues will hardly reassure. On the one hand, the FBI wrongly cracked down on one legit scientist (and now appears to be promoting friendly information exchanges). On the other, the suggestion that it’s cheaper to make your own weaponized anthrax or ricin, rather than a brand new microbe, is no comfort.

Though there are not yet any solutions to the legal and ethical issues, Wolhsen provides a timely airing of what may be going on in a backyard near you.

Pub Date: April 14, 2011

ISBN: 978-1-61723-002-8

Page Count: 256

Publisher: Current

Review Posted Online: Jan. 25, 2011

Kirkus Reviews Issue: Feb. 1, 2011

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THE RIGHT STUFF

Yes: it's high time for a de-romanticized, de-mythified, close-up retelling of the U.S. Space Program's launching—the inside story of those first seven astronauts.

But no: jazzy, jivey, exclamation-pointed, italicized Tom Wolfe "Mr. Overkill" hasn't really got the fight stuff for the job. Admittedly, he covers all the ground. He begins with the competitive, macho world of test pilots from which the astronauts came (thus being grossly overqualified to just sit in a controlled capsule); he follows the choosing of the Seven, the preparations for space flight, the flights themselves, the feelings of the wives; and he presents the breathless press coverage, the sudden celebrity, the glorification. He even throws in some of the technology. But instead of replacing the heroic standard version with the ring of truth, Wolfe merely offers an alternative myth: a surreal, satiric, often cartoony Wolfe-arama that, especially since there isn't a bit of documentation along the way, has one constantly wondering if anything really happened the way Wolfe tells it. His astronauts (referred to as "the brethren" or "The True Brothers") are obsessed with having the "right stuff" that certain blend of guts and smarts that spells pilot success. The Press is a ravenous fool, always referred to as "the eternal Victorian Gent": when Walter Cronkite's voice breaks while reporting a possible astronaut death, "There was the Press the Genteel Gent, coming up with the appropriate emotion. . . live. . . with no prompting whatsoever!" And, most off-puttingly, Wolfe presumes to enter the minds of one and all: he's with near-drowing Gus Grissom ("Cox. . . That face up there!—it's Cox. . . Cox knew how to get people out of here! . . . Cox! . . ."); he's with Betty Grissom angry about not staying at Holiday Inn ("Now. . . they truly owed her"); and, in a crude hatchet-job, he's with John Glenn furious at Al Shepard's being chosen for the first flight, pontificating to the others about their licentious behavior, or holding onto his self-image during his flight ("Oh, yes! I've been here before! And I am immune! I don't get into corners I can't get out of! . . . The Presbyterian Pilot was not about to foul up. His pipeline to dear Lord could not be clearer"). Certainly there's much here that Wolfe is quite right about, much that people will be interested in hearing: the P-R whitewash of Grissom's foul-up, the Life magazine excesses, the inter-astronaut tensions. And, for those who want to give Wolfe the benefit of the doubt throughout, there are emotional reconstructions that are juicily shrill.

But most readers outside the slick urban Wolfe orbit will find credibility fatally undermined by the self-indulgent digressions, the stylistic excesses, and the broadly satiric, anti-All-American stance; and, though The Right Stuff has enough energy, sass, and dirt to attract an audience, it mostly suggests that until Wolfe can put his subject first and his preening writing-persona second, he probably won't be a convincing chronicler of anything much weightier than radical chic.

Pub Date: Sept. 24, 1979

ISBN: 0312427565

Page Count: 370

Publisher: Farrar, Straus and Giroux

Review Posted Online: Oct. 13, 2011

Kirkus Reviews Issue: Sept. 1, 1979

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WHY FISH DON'T EXIST

A STORY OF LOSS, LOVE, AND THE HIDDEN ORDER OF LIFE

A quirky wonder of a book.

A Peabody Award–winning NPR science reporter chronicles the life of a turn-of-the-century scientist and how her quest led to significant revelations about the meaning of order, chaos, and her own existence.

Miller began doing research on David Starr Jordan (1851-1931) to understand how he had managed to carry on after the 1906 San Francisco earthquake destroyed his work. A taxonomist who is credited with discovering “a full fifth of fish known to man in his day,” Jordan had amassed an unparalleled collection of ichthyological specimens. Gathering up all the fish he could save, Jordan sewed the nameplates that had been on the destroyed jars directly onto the fish. His perseverance intrigued the author, who also discusses the struggles she underwent after her affair with a woman ended a heterosexual relationship. Born into an upstate New York farm family, Jordan attended Cornell and then became an itinerant scholar and field researcher until he landed at Indiana University, where his first ichthyological collection was destroyed by lightning. In between this catastrophe and others involving family members’ deaths, he reconstructed his collection. Later, he was appointed as the founding president of Stanford, where he evolved into a Machiavellian figure who trampled on colleagues and sang the praises of eugenics. Miller concludes that Jordan displayed the characteristics of someone who relied on “positive illusions” to rebound from disaster and that his stand on eugenics came from a belief in “a divine hierarchy from bacteria to humans that point[ed]…toward better.” Considering recent research that negates biological hierarchies, the author then suggests that Jordan’s beloved taxonomic category—fish—does not exist. Part biography, part science report, and part meditation on how the chaos that caused Miller’s existential misery could also bring self-acceptance and a loving wife, this unique book is an ingenious celebration of diversity and the mysterious order that underlies all existence.

A quirky wonder of a book.

Pub Date: April 14, 2020

ISBN: 978-1-5011-6027-1

Page Count: 224

Publisher: Simon & Schuster

Review Posted Online: Jan. 1, 2020

Kirkus Reviews Issue: Feb. 1, 2020

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