A wild ride with some important lessons.

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PATIENT NUMBER ONE

A TRUE STORY OF HOW ONE CEO TOOK ON CANCER AND BIG BUSINESS IN THE FIGHT OF HIS LIFE

Murdock was 49 in 1996, the CEO of a biotech company named CellPro, when he was diagnosed with acute lymphoma. Ensuing radiation and chemotherapy treatments failed to knock the disease back, and Murdock was medically doomed—except that his CellPro scientists had been developing a blood-filtering device that now had the potential to save his life. Unfortunately, the device was nowhere near even the testing stage—and even farther from the point where it could be approved by the government for human testing. To make matters worse, CellPro was involved in a lawsuit with the medical equipment giant Baxter Healthcare, which claimed that CellPro had violated a patent during the development process. Murdock has hold of myriad stories here—the lawsuit, his illness, the research race against time, government restraints on research, big business versus small upstarts, the horrors of bone marrow transplants, the ordeals faced by his family, the perfidy of ex-colleagues—and he successfully intertwines all these into a riveting whole. Strident, opinionated, and one-sided as far as the legal questions, yes—but Murdock has survived, and he has some heavy-duty finger-pointing to do here. Others may have made more reasoned arguments against government and big business strangling creative scientific research; but no one can beat Murdock’s personal urgency.

A wild ride with some important lessons.

Pub Date: May 1, 2000

ISBN: 0-609-60391-4

Page Count: 320

Publisher: Crown

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: April 15, 2000

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Skloot's meticulous, riveting account strikes a humanistic balance between sociological history, venerable portraiture and...

THE IMMORTAL LIFE OF HENRIETTA LACKS

A dense, absorbing investigation into the medical community's exploitation of a dying woman and her family's struggle to salvage truth and dignity decades later.

In a well-paced, vibrant narrative, Popular Science contributor and Culture Dish blogger Skloot (Creative Writing/Univ. of Memphis) demonstrates that for every human cell put under a microscope, a complex life story is inexorably attached, to which doctors, researchers and laboratories have often been woefully insensitive and unaccountable. In 1951, Henrietta Lacks, an African-American mother of five, was diagnosed with what proved to be a fatal form of cervical cancer. At Johns Hopkins, the doctors harvested cells from her cervix without her permission and distributed them to labs around the globe, where they were multiplied and used for a diverse array of treatments. Known as HeLa cells, they became one of the world's most ubiquitous sources for medical research of everything from hormones, steroids and vitamins to gene mapping, in vitro fertilization, even the polio vaccine—all without the knowledge, must less consent, of the Lacks family. Skloot spent a decade interviewing every relative of Lacks she could find, excavating difficult memories and long-simmering outrage that had lay dormant since their loved one's sorrowful demise. Equal parts intimate biography and brutal clinical reportage, Skloot's graceful narrative adeptly navigates the wrenching Lack family recollections and the sobering, overarching realities of poverty and pre–civil-rights racism. The author's style is matched by a methodical scientific rigor and manifest expertise in the field.

Skloot's meticulous, riveting account strikes a humanistic balance between sociological history, venerable portraiture and Petri dish politics.

Pub Date: Feb. 9, 2010

ISBN: 978-1-4000-5217-2

Page Count: 320

Publisher: Crown

Review Posted Online: Dec. 22, 2010

Kirkus Reviews Issue: Jan. 1, 2010

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Authoritative and, most helpfully, accessible.

HEALING OUR VILLAGE

A SELF-CARE GUIDE TO DIABETES CONTROL

Self-help guide for diabetes sufferers, mostly in question-and-answer format, with an emphasis on helping racial and ethnic minority diabetics.

Coleman is a pharmacist with a doctorate in her specialty, Gavin a Ph.D. and M.D. Aside from acknowledgments and a foreword signed by Gavin alone, their voices and expertise are indistinguishable, offering lucid, simple solutions for diabetes patients. Gavin relates watching his great-grandmother endure debilitating pain as a result of diabetes while he visited her as a youngster. He remembers hearing adults mention that sugar killed her, and he wondered how something that tasted sweet could cause so much harm. As an adult, he realized that his great-grandmother's affliction could be controlled through treatment. The authors focus on Type 2 diabetes, the most common form in minority populations. An estimated 18.2 million Americans are diabetic, with perhaps 5 million unaware of their situation. About 11 percent of U.S. diabetics are African-American, and about 8 percent are Latino. The question-and-answer format begins with an overview section about diabetes, with an emphasis on risk factors. Section Two covers management of the disease, including nutrition, exercise, blood-testing, oral medications and insulin use. In addition, the authors continually recommend smoking cessation, as well as instructing patients on the readiness of self-treatment. Section Three explains the complications—high blood pressure, high cholesterol and heart disease—that could arise if the condition remains untreated or treated ineffectively. The questions in all of the sections are worded simply, and the answers are usually free of medical jargon. Though the sudden shifts in tone and voice are occasionally jarring, the writing remains clear enough to distill the facts. The real downside here, though: patronizing, laughable illustrations that degrade the overall product.

Authoritative and, most helpfully, accessible.

Pub Date: Jan. 31, 2004

ISBN: 0-9746948-0-0

Page Count: -

Publisher: N/A

Review Posted Online: May 27, 2010

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