A fascinating account of groundbreaking science and the people who make it possible.

THE FOREVER FIX

GENE THERAPY AND THE BOY WHO SAVED IT

Science journalist Lewis (Human Genetics: The Basics, 2010, etc.) examines the emergence of a new medical frontier.

The author opens in 2008, when 8-year-old Corey Haas's attention was drawn to a hot air balloon and he cried out, “It hurts!” Just four days before he had been legally blind due to a mutation that prevented his eyes from processing visual signals; now for the first time in his life, the boy was experiencing the brilliance of full sunlight. Lewis takes readers through the tortuous process that turned young Corey into a poster boy for gene therapy nine years after the tragic death of 18-year-old Jesse Gelsinger from a similar operation. Gelsinger's operation was intended to correct a mutated gene that affected his liver function. In both cases, the mutated gene was identified, and the boys were deliberately “infected” with genetically engineered viruses “sent into the body as microscopic ferries” bearing healthy replacement genes. Gelsinger, however, had suffered from an “unusual and deadly immune-system response” to the virus. Both boys took part in experimental protocols with the informed consent of their guardians, who accepted the risk involved. Lewis chronicles the painstaking search for the specific genes responsible for genetic diseases, and she recounts the human stories behind each discovery, triumph and failure. A sidelight on this absorbing story is the development of rare genetic disorders in populations such as Jewish survivors of pogroms, whose gene pool suffered “the genetic consequences of serial strangulation.” The author also looks at the struggle to make genetic testing freely available to at-risk couples contemplating marriage.

A fascinating account of groundbreaking science and the people who make it possible.

Pub Date: March 13, 2012

ISBN: 978-0-312-68190-6

Page Count: 320

Publisher: St. Martin's

Review Posted Online: Jan. 9, 2012

Kirkus Reviews Issue: Jan. 15, 2012

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A quirky wonder of a book.

WHY FISH DON'T EXIST

A STORY OF LOSS, LOVE, AND THE HIDDEN ORDER OF LIFE

A Peabody Award–winning NPR science reporter chronicles the life of a turn-of-the-century scientist and how her quest led to significant revelations about the meaning of order, chaos, and her own existence.

Miller began doing research on David Starr Jordan (1851-1931) to understand how he had managed to carry on after the 1906 San Francisco earthquake destroyed his work. A taxonomist who is credited with discovering “a full fifth of fish known to man in his day,” Jordan had amassed an unparalleled collection of ichthyological specimens. Gathering up all the fish he could save, Jordan sewed the nameplates that had been on the destroyed jars directly onto the fish. His perseverance intrigued the author, who also discusses the struggles she underwent after her affair with a woman ended a heterosexual relationship. Born into an upstate New York farm family, Jordan attended Cornell and then became an itinerant scholar and field researcher until he landed at Indiana University, where his first ichthyological collection was destroyed by lightning. In between this catastrophe and others involving family members’ deaths, he reconstructed his collection. Later, he was appointed as the founding president of Stanford, where he evolved into a Machiavellian figure who trampled on colleagues and sang the praises of eugenics. Miller concludes that Jordan displayed the characteristics of someone who relied on “positive illusions” to rebound from disaster and that his stand on eugenics came from a belief in “a divine hierarchy from bacteria to humans that point[ed]…toward better.” Considering recent research that negates biological hierarchies, the author then suggests that Jordan’s beloved taxonomic category—fish—does not exist. Part biography, part science report, and part meditation on how the chaos that caused Miller’s existential misery could also bring self-acceptance and a loving wife, this unique book is an ingenious celebration of diversity and the mysterious order that underlies all existence.

A quirky wonder of a book.

Pub Date: April 14, 2020

ISBN: 978-1-5011-6027-1

Page Count: 224

Publisher: Simon & Schuster

Review Posted Online: Jan. 2, 2020

Kirkus Reviews Issue: Feb. 1, 2020

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Loads of good explaining, with reminders, time and again, of how much remains unknown, neatly putting the death of science...

A SHORT HISTORY OF NEARLY EVERYTHING

Bryson (I'm a Stranger Here Myself, 1999, etc.), a man who knows how to track down an explanation and make it confess, asks the hard questions of science—e.g., how did things get to be the way they are?—and, when possible, provides answers.

As he once went about making English intelligible, Bryson now attempts the same with the great moments of science, both the ideas themselves and their genesis, to resounding success. Piqued by his own ignorance on these matters, he’s egged on even more so by the people who’ve figured out—or think they’ve figured out—such things as what is in the center of the Earth. So he goes exploring, in the library and in company with scientists at work today, to get a grip on a range of topics from subatomic particles to cosmology. The aim is to deliver reports on these subjects in terms anyone can understand, and for the most part, it works. The most difficult is the nonintuitive material—time as part of space, say, or proteins inventing themselves spontaneously, without direction—and the quantum leaps unusual minds have made: as J.B.S. Haldane once put it, “The universe is not only queerer than we suppose; it is queerer than we can suppose.” Mostly, though, Bryson renders clear the evolution of continental drift, atomic structure, singularity, the extinction of the dinosaur, and a mighty host of other subjects in self-contained chapters that can be taken at a bite, rather than read wholesale. He delivers the human-interest angle on the scientists, and he keeps the reader laughing and willing to forge ahead, even over their heads: the human body, for instance, harboring enough energy “to explode with the force of thirty very large hydrogen bombs, assuming you knew how to liberate it and really wished to make a point.”

Loads of good explaining, with reminders, time and again, of how much remains unknown, neatly putting the death of science into perspective.

Pub Date: May 6, 2003

ISBN: 0-7679-0817-1

Page Count: 304

Publisher: Broadway

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: April 1, 2003

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