THE TRANSFORMED CELL

UNLOCKING THE MYSTERIES OF CANCER

The exciting story of an idea whose time has come—and of the man who pioneered it. Rosenberg is that rare combination of surgeon and research scientist who early on decided he wanted to take on the challenge of cancer. His patients are all terminal, all failures to chemotherapy, radiation, and surgery. His idea: attack the cancer cells with the body's own immune cells—in particular the specialized T lymphocytes capable of killing cells. The rub was how to get quantities of these cells, ensure that they would attack the cancer cells and only the cancer cells, not produce dire side effects, and achieve long-lasting effects. To do all this, Rosenberg and his team at the National Institutes of Health had to surmount enormous hurdles: extracting T cells from animals and humans, priming them to grow in tissue culture, making sure they retained their killing ability, infusing them back into the live animals and humans.... The work, the frustration, the day-to-day drudgery and disappointments are all told here, with the occasional moment of triumph that galvanizes the team. The story unfolds with the discovery of new families of growth factors—the interleukins- -and a new breed of lymphocyte: the tumor-infiltrating lymphocyte. There's also a commercial story with a competition between biotech companies and, as techniques evolve, a gene-therapy story involving inserting foreign genes into patients' T cells to increase their potency. And then there are the patients, all graphically presented. Many were not helped, but enough have survived, their tumors melted away, to demonstrate that there's a new and powerful cancer therapy on the horizon. And that there are scientists like Rosenberg doing their all to make the therapy work.

Pub Date: Sept. 1, 1992

ISBN: 0-399-13749-1

Page Count: 368

Publisher: Putnam

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: July 1, 1992

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THE END OF ILLNESS

Oncologist Agus (Medicine and Engineering/Univ. of Southern California) predicts that the application of advanced technology for modeling complex systems will transform 21st-century medicine.

The author writes that a remark Nobel Laureate Murray Gell-Mann made to him in 2009—“Look at cancer as a system"—transformed the way he views his own specialty and the entire field of preventative medicine. It made him realize that “[r]ather than honoring the body as the exceedingly complex system that it is, we keep looking for the individual gene that has gone awry, or for the one ‘secret’ that can improve our health.” Agus writes that although the ability to sequence the entire human genome is a great step forward, it is insufficient for achieving a significant breakthrough. Even though it may start with a mutation, cancer “is a dynamic process that's happening…far from the confines of a static piece of DNA”—it involves the body's immune system, its ability to regulate cell growth, metabolism and more. Agus directs his university’s Center for Applied Molecular Medicine and is the co-founder of two personalized medicine companies, Applied Proteomics and Navigenics. His hope is that their research will contribute to developing better analytical tools for preventative medicine and for the treatment of cancers. These will address the functioning of the body as a whole, applying digital technology already used by physicists to provide virtual models of cancers and model the action of proteins that regulate cell communication in the body. He also hopes to develop tools that will provide information on the concentration of different proteins in a drop of blood taken from a patient, which may reveal the onset of disease. The author also includes some guiding principles and warnings about certain healthy practices that may not be so healthy. A refreshing change of pace in the medical field, but by venturing beyond his field of expertise to pontificate on a wide range of subjects, Agus makes his otherwise intriguing narrative difficult to follow.  

 

Pub Date: Jan. 1, 2012

ISBN: 978-1-4516-1017-8

Page Count: 288

Publisher: Free Press

Review Posted Online: Nov. 6, 2011

Kirkus Reviews Issue: Nov. 15, 2011

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An absorbing, wide-ranging story of humans’ relationship with the water.

WHY WE SWIM

A study of swimming as sport, survival method, basis for community, and route to physical and mental well-being.

For Bay Area writer Tsui (American Chinatown: A People's History of Five Neighborhoods, 2009), swimming is in her blood. As she recounts, her parents met in a Hong Kong swimming pool, and she often visited the beach as a child and competed on a swim team in high school. Midway through the engaging narrative, the author explains how she rejoined the team at age 40, just as her 6-year-old was signing up for the first time. Chronicling her interviews with scientists and swimmers alike, Tsui notes the many health benefits of swimming, some of which are mental. Swimmers often achieve the “flow” state and get their best ideas while in the water. Her travels took her from the California coast, where she dove for abalone and swam from Alcatraz back to San Francisco, to Tokyo, where she heard about the “samurai swimming” martial arts tradition. In Iceland, she met Guðlaugur Friðþórsson, a local celebrity who, in 1984, survived six hours in a winter sea after his fishing vessel capsized, earning him the nickname “the human seal.” Although humans are generally adapted to life on land, the author discovered that some have extra advantages in the water. The Bajau people of Indonesia, for instance, can do 10-minute free dives while hunting because their spleens are 50% larger than average. For most, though, it’s simply a matter of practice. Tsui discussed swimming with Dara Torres, who became the oldest Olympic swimmer at age 41, and swam with Kim Chambers, one of the few people to complete the daunting Oceans Seven marathon swim challenge. Drawing on personal experience, history, biology, and social science, the author conveys the appeal of “an unflinching giving-over to an element” and makes a convincing case for broader access to swimming education (372,000 people still drown annually).

An absorbing, wide-ranging story of humans’ relationship with the water.

Pub Date: April 14, 2020

ISBN: 978-1-61620-786-1

Page Count: 288

Publisher: Algonquin

Review Posted Online: Jan. 5, 2020

Kirkus Reviews Issue: Feb. 1, 2020

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