An entertaining account of a peripatetic career, academic infighting, and the colorful, charismatic, or eccentric mentors,...
A skillful memoir and account of groundbreaking research by the winner of the 2009 Nobel Prize in chemistry.
Ramakrishnan—the senior scientist at the Medical Research Council Laboratory of Molecular Biology in Cambridge and president of the Royal Society in London—arrived in the United States in 1971 and obtained a doctorate in theoretical physics, but then he lost interest and devoted his life to biology. The author won his prize for his role in determining the structure of the ribosome. Anyone who has taken high school biology knows that the DNA inside each cell guides the assembly of small molecules into huge ones—proteins—that make up every living creature. DNA, discovered in the 1860s, is simple; in the 1950s, learning how it worked jump-started a revolution in biology. Protein assembly occurs in the ribosome, which is complex. Each cell contains millions. Soon after it was first observed in 1955, scientists sought to learn more. Years after joining their efforts, Ramakrishnan realized that “after forty years of trying to solve how ribosomes work by chemical methods alone,” it was impossible “without a more detailed knowledge of the structure.” Working mostly through X-ray crystallography, he and his lab staff gradually teased out its precise makeup. Rewards and fame—mostly within the scientific community—followed. The author also delivers a portrait of the ribosome that will satisfy even undemanding readers. Very few will understand his explanation of crystallography, but it doesn’t matter. Readers will accept that it’s a maddeningly difficult technique as they take in a vivid description of 20 years of frustration, tedium, and improvisation as he slowly approached his goal.
An entertaining account of a peripatetic career, academic infighting, and the colorful, charismatic, or eccentric mentors, colleagues, and competitors the author encountered as well as an often cynical view of the scientific establishment.Pub Date: Nov. 6, 2018
ISBN: 978-0-465-09336-6
Page Count: 304
Publisher: Basic Books
Review Posted Online: Sept. 16, 2018
Kirkus Reviews Issue: Oct. 1, 2018
BOOK REVIEW
SEEN & HEARD
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular...
A neurosurgeon with a passion for literature tragically finds his perfect subject after his diagnosis of terminal lung cancer.
Writing isn’t brain surgery, but it’s rare when someone adept at the latter is also so accomplished at the former. Searching for meaning and purpose in his life, Kalanithi pursued a doctorate in literature and had felt certain that he wouldn’t enter the field of medicine, in which his father and other members of his family excelled. “But I couldn’t let go of the question,” he writes, after realizing that his goals “didn’t quite fit in an English department.” “Where did biology, morality, literature and philosophy intersect?” So he decided to set aside his doctoral dissertation and belatedly prepare for medical school, which “would allow me a chance to find answers that are not in books, to find a different sort of sublime, to forge relationships with the suffering, and to keep following the question of what makes human life meaningful, even in the face of death and decay.” The author’s empathy undoubtedly made him an exceptional doctor, and the precision of his prose—as well as the moral purpose underscoring it—suggests that he could have written a good book on any subject he chose. Part of what makes this book so essential is the fact that it was written under a death sentence following the diagnosis that upended his life, just as he was preparing to end his residency and attract offers at the top of his profession. Kalanithi learned he might have 10 years to live or perhaps five. Should he return to neurosurgery (he could and did), or should he write (he also did)? Should he and his wife have a baby? They did, eight months before he died, which was less than two years after the original diagnosis. “The fact of death is unsettling,” he understates. “Yet there is no other way to live.”
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular clarity.Pub Date: Jan. 19, 2016
ISBN: 978-0-8129-8840-6
Page Count: 248
Publisher: Random House
Review Posted Online: Sept. 29, 2015
Kirkus Reviews Issue: Oct. 15, 2015
PERSPECTIVES
Well-told and admonitory.
Young-rags-to-mature-riches memoir by broker and motivational speaker Gardner.
Born and raised in the Milwaukee ghetto, the author pulled himself up from considerable disadvantage. He was fatherless, and his adored mother wasn’t always around; once, as a child, he spied her at a family funeral accompanied by a prison guard. When beautiful, evanescent Moms was there, Chris also had to deal with Freddie “I ain’t your goddamn daddy!” Triplett, one of the meanest stepfathers in recent literature. Chris did “the dozens” with the homies, boosted a bit and in the course of youthful adventure was raped. His heroes were Miles Davis, James Brown and Muhammad Ali. Meanwhile, at the behest of Moms, he developed a fondness for reading. He joined the Navy and became a medic (preparing badass Marines for proctology), and a proficient lab technician. Moving up in San Francisco, married and then divorced, he sold medical supplies. He was recruited as a trainee at Dean Witter just around the time he became a homeless single father. All his belongings in a shopping cart, Gardner sometimes slept with his young son at the office (apparently undiscovered by the night cleaning crew). The two also frequently bedded down in a public restroom. After Gardner’s talents were finally appreciated by the firm of Bear Stearns, his American Dream became real. He got the cool duds, hot car and fine ladies so coveted from afar back in the day. He even had a meeting with Nelson Mandela. Through it all, he remained a prideful parent. His own no-daddy blues are gone now.
Well-told and admonitory.Pub Date: June 1, 2006
ISBN: 0-06-074486-3
Page Count: 320
Publisher: Amistad/HarperCollins
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: March 15, 2006
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