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AT WAR WITHIN

THE DOUBLE-EDGED SWORD OF IMMUNITY

A lucid, up-to-date account of the body's immune system from a pro who has taught the subject at UCLA for 25 years. Infectious disease is news Big Time these days—it has been ever since AIDS appeared. What is fascinating is the game of catch- up that science has been playing—unraveling the intricacies of the body's immune system and, more recently, its intimate relation to the nervous system. Clark reminds us that just a generation ago the body's defenses were thought to consist only of antibodies: the molecules that destroy foreign invaders. Not only does Clark explain how the body can be stimulated, say, by vaccines, to make millions of antibodies, but he goes into detail about T cells—the other arm of the immune system. T cells (the T is for the thymus, where they are made) come in several varieties, of which the most noted today are the ``killer'' T cells that search and destroy aberrant cells and the CD4 ``helper'' T cells that are killed by the AIDS virus. Sometimes the immune system is overzealous, however, mounting an attack that adds insult and injury: There is a misreading of molecular markers, resulting in attacks on healthy cells, as happens in autoimmune diseases such as multiple sclerosis (the war within), and sometimes there is a need to suppress the system—in the case of organ transplants. Clark's upbeat outlook suggests that we can curb excesses as well as stimulate a weakened immune system with new drugs or gene therapy approaches. He is convinced that ongoing discoveries of the brainimmune system dialogue will lead to new approaches to therapy. He is also aware of the pressing need for organ transplants, raising provocative ethical issues but at the same time providing a valid Uniform Anatomical Gift Act donor card for readers to fill out. A good idea that, given his overall enthusiasm and mastery in explaining complex science, might persuade more than a few readers.

Pub Date: Jan. 1, 1996

ISBN: 0-19-509286-4

Page Count: 288

Publisher: Oxford Univ.

Review Posted Online: May 19, 2010

Kirkus Reviews Issue: Oct. 15, 1995

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DYLAN GOES ELECTRIC!

NEWPORT, SEEGER, DYLAN, AND THE NIGHT THAT SPLIT THE SIXTIES

An enjoyable slice of 20th-century music journalism almost certain to provide something for most readers, no matter one’s...

Music journalist and musician Wald (Talking 'Bout Your Mama: The Dozens, Snaps, and the Deep Roots of Rap, 2014, etc.) focuses on one evening in music history to explain the evolution of contemporary music, especially folk, blues, and rock.

The date of that evening is July 25, 1965, at the Newport Folk Festival, where there was an unbelievably unexpected occurrence: singer/songwriter Bob Dylan, already a living legend in his early 20s, overriding the acoustic music that made him famous in favor of electronically based music, causing reactions ranging from adoration to intense resentment among other musicians, DJs, and record buyers. Dylan has told his own stories (those stories vary because that’s Dylan’s character), and plenty of other music journalists have explored the Dylan phenomenon. What sets Wald's book apart is his laser focus on that one date. The detailed recounting of what did and did not occur on stage and in the audience that night contains contradictory evidence sorted skillfully by the author. He offers a wealth of context; in fact, his account of Dylan's stage appearance does not arrive until 250 pages in. The author cites dozens of sources, well-known and otherwise, but the key storylines, other than Dylan, involve acoustic folk music guru Pete Seeger and the rich history of the Newport festival, a history that had created expectations smashed by Dylan. Furthermore, the appearances on the pages by other musicians—e.g., Joan Baez, the Weaver, Peter, Paul, and Mary, Dave Van Ronk, and Gordon Lightfoot—give the book enough of an expansive feel. Wald's personal knowledge seems encyclopedic, and his endnotes show how he ranged far beyond personal knowledge to produce the book.

An enjoyable slice of 20th-century music journalism almost certain to provide something for most readers, no matter one’s personal feelings about Dylan's music or persona.

Pub Date: July 25, 2015

ISBN: 978-0-06-236668-9

Page Count: 368

Publisher: Dey Street/HarperCollins

Review Posted Online: May 15, 2015

Kirkus Reviews Issue: June 1, 2015

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NUTCRACKER

This is not the Nutcracker sweet, as passed on by Tchaikovsky and Marius Petipa. No, this is the original Hoffmann tale of 1816, in which the froth of Christmas revelry occasionally parts to let the dark underside of childhood fantasies and fears peek through. The boundaries between dream and reality fade, just as Godfather Drosselmeier, the Nutcracker's creator, is seen as alternately sinister and jolly. And Italian artist Roberto Innocenti gives an errily realistic air to Marie's dreams, in richly detailed illustrations touched by a mysterious light. A beautiful version of this classic tale, which will captivate adults and children alike. (Nutcracker; $35.00; Oct. 28, 1996; 136 pp.; 0-15-100227-4)

Pub Date: Oct. 28, 1996

ISBN: 0-15-100227-4

Page Count: 136

Publisher: Harcourt

Review Posted Online: May 19, 2010

Kirkus Reviews Issue: Aug. 15, 1996

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