Fascinating and important material, though it deserves better exposition.
A leading neurologist and critically praised science writer (The Feeling of What Happens, 1999, etc.) argues that research on human emotions supports the 17th-century philosopher’s conclusions about the mind-body problem.
Damasio (Neurology/Univ. of Iowa Medical Center) begins by describing his visit to Spinoza's home and grave in the Hague. Spinoza's ideas, the author reminds us, were so radical that they were suppressed for decades after his death in 1677, though they survived to be picked up by Enlightenment thinkers and to influence many modern scientists. At the center of his philosophy was the assertion that the mind, and by implication the soul, was not separate from the body but intimately connected to it. At this point, Damasio launches into a detailed summary of the neurological evidence that emotions and feelings, which he carefully distinguishes, arise directly from the brain's imaging of the body’s physical states. Studies of patients with injuries to discrete areas of the brain indicate that specific sites are responsible for specific emotional states, he notes. Moreover, the chemical and physical events leading to feelings can often be traced with considerable accuracy. Unfortunately, the author’s account of these potentially revolutionary investigations is highly abstract and couched in reader-unfriendly jargon. The evidence seems to be that even such exalted emotions as altruism and civic responsibility can be accounted for by physical processes based in the evolutionary needs of the human organism to survive and reproduce. The feeling of contentment that follows ethical behavior is similar to those called up by acts that directly benefit the organism. Having made these points, the narrative returns to an account of Spinoza's life, with particular emphasis on his estrangement from the Portuguese Sephardic community in the Netherlands and his impact on later thinkers. The Spinoza sections flow smoothly; this would have been far more valuable if the neurological sections were as clear and engaging. Even so, it will reward close study.
Fascinating and important material, though it deserves better exposition.Pub Date: Feb. 3, 2003
ISBN: 0-15-100557-5
Page Count: 352
Publisher: Harcourt
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Dec. 15, 2002
BOOK REVIEW
An exposition of the revolutionary changes in medicine coming in the next century as well as discussion of some of the ethical problems these will create. The distinguished Clark, professor emeritus of immunology at UCLA (Sex and the Origins of Death, 1996, etc.), attempts to explain to nonscientists the biology underlying molecular medicine. This is no small undertaking, and Clark is only partly successful. For the layperson, his work requires careful reading of dense text, mastery of a mysterious new vocabulary—``recombinant plasmids,'' ``antisense mRNA''—and study of complex diagrams. After these demanding biochemistry lessons, Clark turns to a fascinating discussion of what it all means in terms of health. He details the current state of gene therapy in treating cystic fibrosis and severe combined immune deficiency (the Bubble Boy disorder), in which copies of normal genes are being successfully introduced into the living cells of individuals with defective genes. In cancer, the ultimate goal of gene therapy is to alter or kill every tumor cell, and in AIDS to neutralize the effects of HIV. Clark, who is optimistic about reaching these goals, then devotes a chapter each to the profound effects on public health that DNA vaccination (injecting a gene from a pathogen, which would be more effective than today's vaccines) will bring in the next century and to the significance of the Human Genome Project, due to be completed shortly after the turn of the century. He clearly sees an educated public as the best defense against misuse of genetic information, for instance, altering a fetus's genetic makeup with the best of medical intentions but without knowing all the consequences of doing so. Although Clark insists that if one is to understand molecular medicine, one must first understand molecular biology, those who find his biology lectures too academic for comfort can still savor the well-wrought medical and ethical discussions.
Pub Date: Nov. 1, 1997
ISBN: 0-19-511730-1
Page Count: 240
Publisher: Oxford Univ.
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Sept. 15, 1997
In 1270, one year before the start of Marco Polo's fabled adventure, a Jewish merchant from the Adriatic port of Ancona set sail for the Orient; over 700 years later, his recently discovered account affords a rare and fascinating glimpse into the peoples, commerce, and thought of the 13th century. Selbourne, a former Oxford professor with an interest in Judaica, presents a fully annotated, very readable translation from the medieval Italian. It reveals Jacob d'Ancona as a savvy businessman, a scholar, a knowledgeable healer—and someone who never shies from disputation. Jacob sails to the eastern Mediterranean; journeys overland to Basra, where he attends the wedding of his son to a wealthy merchant's daughter; crosses the Arabian Sea, alighting on India's Malabar Coast; and then via Sumatra sails north to the Chinese port of Zaitun, the ``City of Light.'' Readers may be surprised to learn that Europeans of all stripes, as well as Saracens, or Muslims, had already been engaged in thriving trade with the Chinese for perhaps hundreds of years, Jewish merchants being among the most prominent. Zaitun itself was a Sodom of sorts: Its ``light'' is a consequence of the all-night commerce in human pleasures, which the pious Jacob abhors. But it is also a center of learning and a great agglomeration of peoples from the known medieval world. During his five-month sojourn, Jacob becomes involved in the intellectual and practical debates swirling around the city, which faced imminent invasion by Kublai Khan, to whom Polo would shortly become an advisor. Jacob's somewhat prolix disquisitions on piety and religion, the relationships among Jews, Christians, and Muslims, and the wisdom of confronting the Mongols earn him both admiration and enmity, and he must finally flee the city, though not without considerable financial success. An exciting, stimulating, and unique human document, and one that will no doubt become a much-trumpeted addition to the historical record. (50 b&w photos)
Pub Date: Nov. 13, 1997
ISBN: 0-316-17353-3
Page Count: 384
Publisher: Little, Brown
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Sept. 1, 1997
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