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Alzheimer's Disease

Name: Alzheimer's Disease
Author: Lawrence Broxmeyer
ISBN: 978-1-4912-8735-4

HOW ITS BACTERIAL CAUSE WAS FOUND AND THEN DISCARDED

by Lawrence Broxmeyer ‧ RELEASE DATE: Aug. 3, 2016

A difficult but rewarding look at a major scientific dispute.

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A historical account of the debate over the cause of Alzheimer’s disease.

Alzheimer’s is both debilitating and near ubiquitous; if one lives long enough, Broxmeyer (Autism, 2014, etc.) observes, the odds are high that one will suffer some iteration of it. He also notes that Alois Alzheimer, the scientist after whom the disease is named, likely contributed as much as anyone to the general confusion regarding its precise nature. In 1901, Broxmeyer says, Alzheimer examined Auguste Deter—a woman suffering from diminished memory and behavioral abnormality—and seemed determined to avoid implicating tuberculosis even though the potential link between the two was clear. At the start of the 20th century, TB was troublingly common, but Alzheimer insisted that whatever infectious disease caused the newly discovered malady was itself altogether new. However, the author points out, German neuropathologist Oskar Fischer observed in autopsies that brains addled with Alzheimer’s disease also exhibited a germ associated with TB. Later, it would be discovered that tubercular microbes could generate amyloid fibrils very similar to those found in the Alzheimer’s-related plaques and seemed to affect the brain’s immune cells in the same way. The author is an internist and a medical researcher, and his double mastery of both the scientific minutiae and historical nuances of his subject matter is breathtaking. This is more than an account of a scientific debate—it’s also an examination of the sometimes-unempirical way that such debate proceeds, as it’s conducted by human beings with agendas of their own. The science in this book can be formidably complex, and although Broxmeyer seems to make a concerted effort toward clarity, his work isn’t for the casual layperson. As a result, although it’s a relatively short book—less than 200 pages of text—it is by no means a quick read. Nevertheless, readers with strong science backgrounds will be impressed by the author’s undeniable competence, as well as his journalistic approach to chartering the evolution of thought regarding one of our era’s most challenging diseases.

A difficult but rewarding look at a major scientific dispute.

Pub Date: Aug. 3, 2016

ISBN: 978-1-4912-8735-4

Page Count: 190

Publisher: CreateSpace

Review Posted Online: Sept. 14, 2016

Review Program: Kirkus Indie

Categories:

GENERAL NONFICTION

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LIFE IS SO GOOD

by George Dawson & Richard Glaubman ‧ RELEASE DATE: Feb. 1, 2000

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The memoir of George Dawson, who learned to read when he was 98, places his life in the context of the entire 20th century in this inspiring, yet ultimately blighted, biography. Dawson begins his story with an emotional bang: his account of witnessing the lynching of a young African-American man falsely accused of rape. America’s racial caste system and his illiteracy emerge as the two biggest obstacles in Dawson’s life, but a full view of the man overcoming the obstacles remains oddly hidden. Travels to Ohio, Canada, and Mexico reveal little beyond Dawson’s restlessness, since nothing much happens to him during these wanderings. Similarly, the diverse activities he finds himself engaging in—bootlegging in St. Louis, breaking horses, attending cockfights—never really advance the reader’s understanding of the man. He calls himself a “ladies’ man” and hints at a score of exciting stories, but then describes only his decorous marriage. Despite the personal nature of this memoir, Dawson remains a strangely aloof figure, never quite inviting the reader to enter his world. In contrast to Dawson’s diffidence, however, Glaubman’s overbearing presence, as he repeatedly parades himself out to converse with Dawson, stifles any momentum the memoir might develop. Almost every chapter begins with Glaubman presenting Dawson with a newspaper clipping or historical fact and asking him to comment on it, despite the fact that Dawson often does not remember or never knew about the event in question. Exasperated readers may wonder whether Dawson’s life and his accomplishments, his passion for learning despite daunting obstacles, is the tale at hand, or whether the real issue is his recollections of Archduke Ferdinand. Dawson’s achievements are impressive and potentially exalting, but the gee-whiz nature of the tale degrades it to the status of yet another bowl of chicken soup for the soul, with a narrative frame as clunky as an old bone.

Pub Date: Feb. 1, 2000

ISBN: 0-375-50396-X

Page Count: 288

Publisher: Random House

Review Posted Online: May 19, 2010

Kirkus Reviews Issue: Dec. 15, 1999

Categories:

GENERAL NONFICTION

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THIS IS SHAKESPEARE

by Emma Smith ‧ RELEASE DATE: April 21, 2020

A brief but sometimes knotty and earnest set of studies best suited for Shakespeare enthusiasts.

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A brisk study of 20 of the Bard’s plays, focused on stripping off four centuries of overcooked analysis and tangled reinterpretations.

“I don’t really care what he might have meant, nor should you,” writes Smith (Shakespeare Studies/Oxford Univ.; Shakespeare’s First Folio: Four Centuries of an Iconic Book, 2016, etc.) in the introduction to this collection. Noting the “gappy” quality of many of his plays—i.e., the dearth of stage directions, the odd tonal and plot twists—the author strives to fill those gaps not with psychological analyses but rather historical context for the ambiguities. She’s less concerned, for instance, with whether Hamlet represents the first flower of the modern mind and instead keys into how the melancholy Dane and his father share a name, making it a study of “cumulative nostalgia” and our difficulty in escaping our pasts. Falstaff’s repeated appearances in multiple plays speak to Shakespeare’s crowd-pleasing tendencies. A Midsummer Night’s Dream is a bawdier and darker exploration of marriage than its teen-friendly interpretations suggest. Smith’s strict-constructionist analyses of the plays can be illuminating: Her understanding of British mores and theater culture in the Elizabethan era explains why Richard III only half-heartedly abandons its charismatic title character, and she is insightful in her discussion of how Twelfth Night labors to return to heterosexual convention after introducing a host of queer tropes. Smith's Shakespeare is eminently fallible, collaborative, and innovative, deliberately warping play structures and then sorting out how much he needs to un-warp them. Yet the book is neither scholarly nor as patiently introductory as works by experts like Stephen Greenblatt. Attempts to goose the language with hipper references—Much Ado About Nothing highlights the “ ‘bros before hoes’ ethic of the military,” and Falstaff is likened to Homer Simpson—mostly fall flat.

A brief but sometimes knotty and earnest set of studies best suited for Shakespeare enthusiasts.