Sobering, humbling, and extraordinarily rich reading from a wise and gifted writer who sees how far we have come—but how...
A panoramic history of the gene and how genetics “resonate[s] far beyond the realms of science.”
Mukherjee (Medicine/Columbia Univ.; The Laws of Medicine, 2015, etc.), who won the Pulitzer Prize for his history of cancer, The Emperor of All Maladies (2010), begins with Mendel and his “pea-flower garden,” and he never lets readers forget the social, cultural, and ethical implications of genetics research. Indeed, he dedicates the book to his grandmother, who raised two mentally ill children, and to Carrie Buck, the Virginia woman judged “feeble-minded” and sterilized according to eugenics laws passed in the 1920s. After Mendel, Mukherjee describes Thomas Morgan’s fruit fly studies in the 1900s, and he goes on to trace the steps leading to the discovery of the double helix, the deciphering of the genetic code, and the technological advances that have created ethical dilemmas. Early on, there was recombinant DNA, the insertion of genes from one species into another, and this led to mandates initially proscribing certain experiments. Then, there were the first disastrous attempts at gene therapy, which consisted of arrogant and sloppy science. Meanwhile, the human genome has been mapped, more and more genes have been associated with certain diseases (and even behaviors), and a new technique has been developed that permits the removing or replacing of specific genetic defects. Are we ready to apply that to an individual patient? Should it apply to sperm and egg cells so as to affect future generations? Mukherjee ponders these issues in the final chapters and epilogue, ultimately seeing the need for more research about the information coded in the human genome, since so much of it does not consist of genes. Throughout, the author provides vivid portraits of the principal players and enough accessible scientific information to bring general readers into the process of genetic lab science.
Sobering, humbling, and extraordinarily rich reading from a wise and gifted writer who sees how far we have come—but how much farther we have to go to understand our human nature and destiny.Pub Date: May 17, 2016
ISBN: 978-1-4767-3350-0
Page Count: 592
Publisher: Scribner
Review Posted Online: March 2, 2016
Kirkus Reviews Issue: March 15, 2016
BOOK REVIEW
BOOK REVIEW
The history of the USS Monitor, written with panache, sophisticated understanding, and attention to detail by deKay (Chronicles of the Frigate Macedonian, not reviewed). The Monitor may have been a ``doughty little Civil War ironclad,'' as deKay writes, but it was an elegantly minimalist mechanical marvel, a milestone in naval technology, with a design so original (including a revolving turret), it had 40 patentable innovations. At a time when naval strategy relied upon ships of the line—colossal square riggers with 120 guns and a crew of up to 1,200—the Monitor was a freak and a harbinger: armor-clad, steam- powered, with a mere two guns and a crew of 58. It was hardly the first of its kind—the king of Syracuse had an armor-plated vessel in the third century b.c., and Fulton's Clermont was steaming along in 1807—yet it was the right ship, in the right spot, at the right time. DeKay tells the Monitor's story with building suspense: It was the brainchild of the Swedish engineer John Ericsson, which became the best hope of the Union forces to maintain a critical blockade at Hampton Roads, Va. Finally, the author relates the wicked confrontation with the Confederate's ``awesome dark monster,'' Merrimac, another ironclad whose tale deKay sharply limns. It was a standoff at first, then the smaller Monitor exploited its opponent's unwieldiness to gain ascendancy. DeKay's tale is a richly brocaded one, serving up the sweetheart deals and political shenanigans that marked the Monitor's progress; elaborating on the rumors that flew before the epic battle like expectations before a championship heavyweight fight; bringing into play the weather and tides and most any other thing that touched upon events. This book is, simply, a little treasure. (25 b&w illustrations, not seen)
Pub Date: Nov. 13, 1997
ISBN: 0-8027-1330-0
Page Count: 240
Publisher: Walker
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Sept. 15, 1997
BOOK REVIEW
A heap of difficult-to-read information on a relevant topic.
A textbook on “biocatastrophe” as a global public-safety issue.
Biocatastrophe is a term the authors coined for “the simultaneous degradation of the Earth’s principal ecosystems, including those inhabited by humans, as a result of the radical alteration of the Earth’s climate and natural landscapes.” This hefty text aims to explore the causes of biocatastrophe and the significance of its effects on the human and natural world. The authors put this crisis into the context of other ecological crises, like global warming, urbanization, deforestation, mass extinction and loss of ecosystem biodiversity–all of which, they write, are elements of an overarching biocatastrophe. In neatly organized chapters, the authors–who were inspired to write the book after their experiences as volunteer firemen in the 1960s and ’70s–detail the history of human ecology and how biocatastrophe fits into health, politics and economics. The text proves it is up-to-date with contextual information on the global financial crisis and evidence that two seemingly unrelated activities (the environment and the global economy) are indeed linked. Though the authors don’t explicitly describe our future, they strongly hint that Earth’s citizens will have to redefine their values and prepare to live with finite resources. To emphasize the sheer magnitude of biocatastrophe, nothing that can be defined as a military, industrial or commercial activity is spared the author’s dissection. The sentences are packed with information, and an editor would do well to streamline the writing into more digestible servings. The resources in the back of the book are ample–glossary, charts and several appendices provide sources and helpful data.
A heap of difficult-to-read information on a relevant topic.Pub Date: May 11, 2009
ISBN: 978-0-9769153-8-6
Page Count: -
Publisher: N/A
Review Posted Online: May 23, 2010
Review Program: Kirkus Indie
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