by Siddhartha Mukherjee ‧ RELEASE DATE: Oct. 25, 2022
Another outstanding addition to the author’s oeuvre, which we hope will continue to grow for years to come.
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A luminous journey into cellular biology.
Mukherjee, a physician, professor of medicine, and Pulitzer Prize–winning author (The Emperor of All Maladies), has a knack for explaining difficult ideas in terms that are both straightforward and interesting. In his latest, he punctuates his scientific explanations with touching, illustrative stories of people coping with cell-based illnesses, tracking how the knowledge gleaned from those cases contributed to further scientific advancement. In the early chapters, the author traces the discovery of cells as the building blocks of animal and plant life, with the invention of the microscope making analysis possible. With this development, researchers could better understand the roles of cells in human physiology, including the illnesses that rogue cells could cause. In the middle section, Mukherjee investigates how scientists then moved on to study the processes through which cells become specialized by function and how some turn cancerous. The identification of the phases of cell division and the discovery of DNA were crucial breakthroughs, opening the way for a new generation of treatments. Mukherjee occasionally digresses from the historical story to provide vivid portraits of key researchers, with recollections about his own work. The final section of the book deals with emerging areas of research such as cell manipulation and gene editing as well as new technologies like transplantation. It’s all unquestionably exciting, but the author is careful to acknowledge the knotty ethical considerations. Treating embryos for cellular abnormalities makes medical sense, but the idea of altered human beings has worrying implications. Mukherjee also emphasizes that there is still a great deal we do not know about cells, especially the interactions between types. Understanding the mechanics is one thing, he notes; hearing “the song of the cell” is something else. This poignant idea serves as a suitable coda for a fascinating story related with clarity and common sense.
Another outstanding addition to the author’s oeuvre, which we hope will continue to grow for years to come.Pub Date: Oct. 25, 2022
ISBN: 978-1-982117-35-1
Page Count: 480
Publisher: Scribner
Review Posted Online: June 24, 2022
Kirkus Reviews Issue: Aug. 1, 2022
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by Action Bronson ; photographed by Bonnie Stephens ‧ RELEASE DATE: April 20, 2021
The lessons to draw are obvious: Smoke more dope, eat less meat. Like-minded readers will dig it.
The chef, rapper, and TV host serves up a blustery memoir with lashings of self-help.
“I’ve always had a sick confidence,” writes Bronson, ne Ariyan Arslani. The confidence, he adds, comes from numerous sources: being a New Yorker, and more specifically a New Yorker from Queens; being “short and fucking husky” and still game for a standoff on the basketball court; having strength, stamina, and seemingly no fear. All these things serve him well in the rough-and-tumble youth he describes, all stickball and steroids. Yet another confidence-builder: In the big city, you’ve got to sink or swim. “No one is just accepted—you have to fucking show that you’re able to roll,” he writes. In a narrative steeped in language that would make Lenny Bruce blush, Bronson recounts his sentimental education, schooled by immigrant Italian and Albanian family members and the mean streets, building habits good and bad. The virtue of those habits will depend on your take on modern mores. Bronson writes, for example, of “getting my dick pierced” down in the West Village, then grabbing a pizza and smoking weed. “I always smoke weed freely, always have and always will,” he writes. “I’ll just light a blunt anywhere.” Though he’s gone through the classic experiences of the latter-day stoner, flunking out and getting arrested numerous times, Bronson is a hard charger who’s not afraid to face nearly any challenge—especially, given his physique and genes, the necessity of losing weight: “If you’re husky, you’re always dieting in your mind,” he writes. Though vulgar and boastful, Bronson serves up a model that has plenty of good points, including his growing interest in nature, creativity, and the desire to “leave a legacy for everybody.”
The lessons to draw are obvious: Smoke more dope, eat less meat. Like-minded readers will dig it.Pub Date: April 20, 2021
ISBN: 978-1-4197-4478-5
Page Count: 184
Publisher: Abrams
Review Posted Online: May 5, 2021
Kirkus Reviews Issue: June 1, 2021
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by Rebecca Skloot ‧ RELEASE DATE: Feb. 9, 2010
Skloot's meticulous, riveting account strikes a humanistic balance between sociological history, venerable portraiture and...
A dense, absorbing investigation into the medical community's exploitation of a dying woman and her family's struggle to salvage truth and dignity decades later.
In a well-paced, vibrant narrative, Popular Science contributor and Culture Dish blogger Skloot (Creative Writing/Univ. of Memphis) demonstrates that for every human cell put under a microscope, a complex life story is inexorably attached, to which doctors, researchers and laboratories have often been woefully insensitive and unaccountable. In 1951, Henrietta Lacks, an African-American mother of five, was diagnosed with what proved to be a fatal form of cervical cancer. At Johns Hopkins, the doctors harvested cells from her cervix without her permission and distributed them to labs around the globe, where they were multiplied and used for a diverse array of treatments. Known as HeLa cells, they became one of the world's most ubiquitous sources for medical research of everything from hormones, steroids and vitamins to gene mapping, in vitro fertilization, even the polio vaccine—all without the knowledge, must less consent, of the Lacks family. Skloot spent a decade interviewing every relative of Lacks she could find, excavating difficult memories and long-simmering outrage that had lay dormant since their loved one's sorrowful demise. Equal parts intimate biography and brutal clinical reportage, Skloot's graceful narrative adeptly navigates the wrenching Lack family recollections and the sobering, overarching realities of poverty and pre–civil-rights racism. The author's style is matched by a methodical scientific rigor and manifest expertise in the field.
Skloot's meticulous, riveting account strikes a humanistic balance between sociological history, venerable portraiture and Petri dish politics.Pub Date: Feb. 9, 2010
ISBN: 978-1-4000-5217-2
Page Count: 320
Publisher: Crown
Review Posted Online: Dec. 22, 2010
Kirkus Reviews Issue: Jan. 1, 2010
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