A stirring account of how important scientific research gets done.
Former Los Angeles Times national reporter McDermott (Perfect Soldiers: The 9/11 Hijackers: Who They Were, Why They Did It, 2006) tells the story of the driven neuroscientist Gary Lynch and his ongoing quest to discover the biochemical workings of memory.
Scientists have long been searching for the explanation of how memories are produced in the human brain and how they are stored and recalled. As McDermott explains in 101 Theory Drive—named after the street address of Lynch’s lab—Lynch has obsessively been trying to answer those complex questions for decades. With a chemist, he has also been working on drugs called ampakines, which could theoretically help improve memory function and restore the brain’s cognitive abilities—a potential boon for sufferers of Alzheimer’s and other neurological diseases. Starting in late 2004, McDermott spent nearly two years observing the work in the scientist’s lab. He chronicles the progress of Lynch’s research and provides an engaging portrait of the colorful but not-always-likable Lynch. The author ably explains highly technical concepts of neurology and breaks down complicated ideas in ways that general readers can easily understand. He’s equally at home describing the obsessive Lynch, who is portrayed as ambitious, brilliant and conversant on a dizzying array of subjects, but also impatient, full of self-regard and tough on his staff. The book opens with Lynch alone in his lab, annoyed that the rest of his team dared take a break between Christmas and New Year’s Day. McDermott also pays attention to key members of Lynch’s staff, such as neurophysiologist Eniko Kramar, whose workaholic devotion to Lynch’s work is described by her friends as “just short of self-destructive.”
A stirring account of how important scientific research gets done.Pub Date: April 6, 2010
ISBN: 978-0-375-42538-7
Page Count: 288
Publisher: Pantheon
Review Posted Online: Jan. 19, 2011
Kirkus Reviews Issue: Jan. 1, 2010
Eminently useful, although somewhat contradictory, this admiring intellectual biography of an iconoclastic psychoanalyst recapitulates the strengths and weaknesses of its subject's thought. Karen Horney (18851952) played a key role in the development of psychoanalysis between the wars and transcended her discipline as a feminist thinker. Horney scholar Paris (English/Univ. of Florida) surveys the psychoanalyst's ideas while locating their sources in her personal experiences. He builds on the work of previous biographers Jack Rubins (Karen Horney, 1978) and Susan Quinn (A Mind of Her Own, not reviewed), who brought messy details of Horney's life to light without, he contends, fully relating them to her mature theory. For Paris, Horney's ideas represent her effort to come to grips with her own problems—to perform, as her best-known title has it, a ``self-analysis.'' After a lucid account of Horney's youth in Germany, Paris treats her early, relatively orthodox essays and her subsequent development of a theory of feminine psychology. He shows how pondering social concerns led Horney to consider the cultural dimensions of neurosis and eventually to develop a new paradigm of psychological structure as a complete, ongoing system, rather than an individual story only understandable through recourse to its occluded origins. Her adult life was thorny: Paris discusses her ``female Don Juanism,'' her battles in the bitter psychoanalytic arena, and her difficult affairs with famed rivals like Erich Fromm. Extensive commentaries on Horney's late thought tie these strands together, focusing on ideas about pride and defense strategies expressed in Our Inner Conflicts and Neurosis and Human Growth. Throughout, Paris maintains allegiance to Horney's conviction that we each have a true inner self, even while he depicts stark discontinuities among the facets of her own personality. It will take a grander synthesis than his, one that incorporates wider historical and cultural context, to really resolve this tension between Horney's thought and life. In the interim, however, this serves as a fine introduction to a stimulating thinker whose influence continues to rise as therapy becomes more pragmatic and less dogmatic.
Pub Date: Nov. 1, 1994
ISBN: 0-300-05956-6
Page Count: 288
Publisher: Yale Univ.
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Oct. 1, 1994
Madness and pathos alternate in these selections from the controversial psychoanalyst's (18971957) papers, which document the scientific delusions and personal difficulties that preoccupied him from the mid-1930s through his immigration to America on the eve of WW II. Because materials remain missing, this sequel to 1988's Passion of Youth: An Autobiography, 18971922 begins in 1934. In the intervening years of 192333, Reich's studies of the function of the orgasm and of genital sexuality's effects on character found him moving from psychoanalysis toward physiology and biology. Settling in Oslo, Reich put his radical political activism on the back burner while beginning a new program of experiments to examine nothing less than the fundamental energies of life. The excerpts from his journals and letters collected here form a streamlined narrative of his struggles to gain recognition for the theories to which this work gave rise. Reich believed that his insights represented ``the greatest discovery of the century.'' Readers need not be molecular biologists, however, to be skeptical of this claim: The laboratory jottings reproduced here seem like so much hocus-pocus. Meanwhile, Reich's ravings (``the living arises from the nonliving!!'') escape the lab to infect his accounts of a disintegrating home life. He can't seem to reflect personally on sex without proclaiming, ``My theory is correct!'' His children remain alienated from him, and his lover leaves him, but Reich consoles himself with the idea that his suffering is that of a man of genius. With his 1939 ``discovery'' of orgone, Reich seems to have gone over the edge for sure: ``I yearn for a beautiful woman with no sexual anxieties who will just take me! Have inhaled too much orgone radiation.'' At this point, the deepening shadow of Nazi expansion forces the Jewish and communist Reich's emigration to a credulous New York. Reich comes across as a crank, but a human figure all the same. Ideal material for a screenplay about a 20th-century mad scientist.
Pub Date: Dec. 1, 1994
ISBN: 0-374-11247-9
Page Count: 320
Publisher: Farrar, Straus and Giroux
Review Posted Online: May 19, 2010
Kirkus Reviews Issue: Oct. 1, 1994
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