A rousing, valuable contribution to the history of medicine.

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THE DEMON UNDER THE MICROSCOPE

FROM BATTLEFIELD HOSPITALS TO NAZI LABS, ONE DOCTOR’S HEROIC SEARCH FOR THE WORLD’S FIRST MIRACLE DRUG

The fascinating story of the world’s first antibiotic.

Science-writer Hager (Force of Nature: The Life of Linus Pauling, 1995) asserts that sulfa, which was eventually displaced as a miracle drug by penicillin, holds a unique place in the history of medical science. It banished the notion, widely held among doctors, that chemicals would never be able to cure most diseases; it established the research methods for finding new drugs; and it created the business model for developing them. Hager’s account opens on the battlefields of World War II, where wound infection was a gruesome killer, then moves to postwar Germany, where industrial chemists manipulating azo dye molecules discovered that the addition of sulfanilamide (sulfa) created a chemical with bacteria-fighting properties. In England, doctors tried the new dye-based German wonder drug Prontosil on hospital patients; in France, researchers found that sulfa alone was the effective agent; and in the U.S., great quantities of sulfa-containing patent medicines were soon developed and marketed. The author enlivens his tale with a host of personalities, including German industrialist Carl Duisberg, head of the Bayer company; Heinrich Horlein, who ran Bayer’s pharmaceutical division; researcher Gerhard Domagk, whose work won him a Nobel Prize, which the Nazis would not permit him to accept; and French chemist Ernest Fourneau, whose discovery of the power of sulfa on its own greatly dismayed the German makers of Prontosil. Hager also provides a vivid picture of Germany at the peak of its prestige in the international scientific community and of a very different country under the Nazis. Of special interest is the cautionary tale of the Massengill Company’s Elixir Sulfanilamide, which contained an industrial solvent and killed more than 100 people in the U.S. This disaster led to an overhaul of the nation’s drug laws, including passage of the 1938 Federal Food, Drug and Cosmetic Act. It put an end, the author states, to the era of patent medicines and launched the age of antibiotics.

A rousing, valuable contribution to the history of medicine.

Pub Date: Sept. 19, 2006

ISBN: 1-4000-8213-7

Page Count: 352

Publisher: Harmony

Review Posted Online: May 20, 2010

Kirkus Reviews Issue: July 1, 2006

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Doyle offers another lucid, inspiring chronicle of female empowerment and the rewards of self-awareness and renewal.

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UNTAMED

More life reflections from the bestselling author on themes of societal captivity and the catharsis of personal freedom.

In her third book, Doyle (Love Warrior, 2016, etc.) begins with a life-changing event. “Four years ago,” she writes, “married to the father of my three children, I fell in love with a woman.” That woman, Abby Wambach, would become her wife. Emblematically arranged into three sections—“Caged,” “Keys,” “Freedom”—the narrative offers, among other elements, vignettes about the soulful author’s girlhood, when she was bulimic and felt like a zoo animal, a “caged girl made for wide-open skies.” She followed the path that seemed right and appropriate based on her Catholic upbringing and adolescent conditioning. After a downward spiral into “drinking, drugging, and purging,” Doyle found sobriety and the authentic self she’d been suppressing. Still, there was trouble: Straining an already troubled marriage was her husband’s infidelity, which eventually led to life-altering choices and the discovery of a love she’d never experienced before. Throughout the book, Doyle remains open and candid, whether she’s admitting to rigging a high school homecoming court election or denouncing the doting perfectionism of “cream cheese parenting,” which is about “giving your children the best of everything.” The author’s fears and concerns are often mirrored by real-world issues: gender roles and bias, white privilege, racism, and religion-fueled homophobia and hypocrisy. Some stories merely skim the surface of larger issues, but Doyle revisits them in later sections and digs deeper, using friends and familial references to personify their impact on her life, both past and present. Shorter pieces, some only a page in length, manage to effectively translate an emotional gut punch, as when Doyle’s therapist called her blooming extramarital lesbian love a “dangerous distraction.” Ultimately, the narrative is an in-depth look at a courageous woman eager to share the wealth of her experiences by embracing vulnerability and reclaiming her inner strength and resiliency.

Doyle offers another lucid, inspiring chronicle of female empowerment and the rewards of self-awareness and renewal.

Pub Date: March 10, 2020

ISBN: 978-1-9848-0125-8

Page Count: 352

Publisher: Dial Books

Review Posted Online: Dec. 22, 2019

Kirkus Reviews Issue: Jan. 15, 2020

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This moving, potent testament might have been titled “Black Lives Matter.” Or: “An American Tragedy.”

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BETWEEN THE WORLD AND ME

NOTES ON THE FIRST 150 YEARS IN AMERICA

The powerful story of a father’s past and a son’s future.

Atlantic senior writer Coates (The Beautiful Struggle: A Father, Two Sons, and an Unlikely Road to Manhood, 2008) offers this eloquent memoir as a letter to his teenage son, bearing witness to his own experiences and conveying passionate hopes for his son’s life. “I am wounded,” he writes. “I am marked by old codes, which shielded me in one world and then chained me in the next.” Coates grew up in the tough neighborhood of West Baltimore, beaten into obedience by his father. “I was a capable boy, intelligent and well-liked,” he remembers, “but powerfully afraid.” His life changed dramatically at Howard University, where his father taught and from which several siblings graduated. Howard, he writes, “had always been one of the most critical gathering posts for black people.” He calls it The Mecca, and its faculty and his fellow students expanded his horizons, helping him to understand “that the black world was its own thing, more than a photo-negative of the people who believe they are white.” Coates refers repeatedly to whites’ insistence on their exclusive racial identity; he realizes now “that nothing so essentialist as race” divides people, but rather “the actual injury done by people intent on naming us, intent on believing that what they have named matters more than anything we could ever actually do.” After he married, the author’s world widened again in New York, and later in Paris, where he finally felt extricated from white America’s exploitative, consumerist dreams. He came to understand that “race” does not fully explain “the breach between the world and me,” yet race exerts a crucial force, and young blacks like his son are vulnerable and endangered by “majoritarian bandits.” Coates desperately wants his son to be able to live “apart from fear—even apart from me.”

This moving, potent testament might have been titled “Black Lives Matter.” Or: “An American Tragedy.”

Pub Date: July 8, 2015

ISBN: 978-0-8129-9354-7

Page Count: 176

Publisher: Spiegel & Grau

Review Posted Online: May 6, 2015

Kirkus Reviews Issue: July 1, 2015

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